Global Engagement

Professor CHAN Lik Yuen, Henry

Global Engagement - Associate Dean

Professor, Department of Medicine and Therapeutics
Director, Centre for Liver Health
Director, Office of Global Engagement

Global Engagement - Associate Dean

Professor CHAN Lik Yuen, Henry

Department of Medicine and Therapeutics

Contact Information
Office : (852) 3505-3593
Email :

Department of Medicine and Therapeutics
Division of Gastroenterology and Hepatology
Institute of Digestive Disease
Centre for Liver Health
Office of Global Engagement

Specialist in Gastroenterology and Hepatology

Bachelor of Medicine and Surgery, CUHK MBChB (CUHK)
Doctor of Medicine, CUHK MD (CUHK)
Fellow of Royal College of Physicians of Edinburgh FRCP (Edin)
Fellow of Royal College of Physicians of London FRCP (Lond)
Fellow of Hong Kong College of Physicians FHKCP
Fellow of Hong Kong Academy of Medicine (Medicine) FHKAM (Med)
Fellow of American Association for the Study of Liver Diseases FAASLD

Research Interests
Viral hepatitis, liver fibrosis, liver cancer, anti-viral therapy, fatty liver disease

Additional Information
Honorary appointments
Chairman, Strategic and Technical Advisory Committee for Viral Hepatitis, Western Pacific Regional Office of World Health Organization
Associate editor, Journal of Hepatology
Associate editor, Hepatology International
Associate editor, Seminar of Liver Diseases
Council member, Hong Kong Association for the Study of Liver Diseases

Recent Honours and Awards
Okuda Lecturer, Asia Pacific Digestive Week, 2018
Chainuvati Lecturer, Thai Association for the Study of the Liver, Thailand, 2018
First class award, GuangDong Province Science & Technology Award, 2018
Excellent research award, Food and Health Bureau, Hong Kong, 2014
National Award for Science and Technology Progress 2012 (Second Class) 2012
First-class MOE Higher Education Outstanding Scientific Research Output Award (Scientific and Technological Progress Award), Ministry of Education, 2012
Croucher Senior Medical Research Fellowship, 2011
Sir David Todd Lecture, Hong Kong College of Physicians, 2011
Emerging Leader Lectureship Award, Asia Pacific Digestive Week, 2010
Excellent Research Award (Clinical Studies), Food and Health Bureau, Hong Kong, 2010
Association of Southeast Asian Institutions of Higher Learning-Scopus Young Scientist Award, 2008
Distinguished Research Paper Award for Young Investigators, Hong Kong College of Physicians, 2008
Young Investigator Award, Asian Pacific Association for the Study of the Liver, 2008

Ten Outstanding Young Persons Award, Hong Kong, 2008  
Selected Publications
  1. K Agarwal, M Brunetto, WK Seto, YS Lim, S Fung, P Marcellin, SH Ahn, N Izumi, WL Chuang, H Bae, M Sharma, HLA Janssen, CQ Pan, M Celen, N Furusyo, Shalimar, KT Yoon, H Trinh, JF Flaherty, A Gaggar, A Lau, AL Cathcart, L Lin, N Bhardwaj, V Suri, GM Subramanian, E Gane, M Buti, HLY Chan. 96 weeks treatment of tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of chronic hepatitis B virus infection. J Hepatol 2018;68:672-81.
  2. TCF Yip, GLH Wong, VWS Wong, YK Tse, GCY Lui, KLY Lam, HLY Chan. Durability of hepatitis B surface antigen seroclearance in untreated and nucleos(t)ide analogue-treated patients. J Hepatol 2018;68:63-72.
  3. M Cornberg, VWS Wong, S Locarnini, M Brunetto, HL Janssen, HLY Chan. The role of quantitative hepatitis B surface antigen revisited. J Hepatol 2017;66:398-411.
  4. HLY Chan, S Fung, WK Seto, WL Chuang, CY Chen, HJ Kim, AJ Hui, HLA Janssen, A chowdhury, TY Tsang, R Mehta, E Gane, JF Flaherty, B Massetto, A Gaggar, KM Kitrinos, L Lin, GM Subramanian, JG McHutchison, YS Lim, SK Acharya, K Agarwal, GS-US-320-0110 investigators. Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection: a randomized, double-blind, phase 3, non-inferiority trial. Lancet Gastroenterol Hepatol 2016;1:185-95.
  5. HLY Chan, SH Ahn, TT Chang, CY Peng, D Wong, CS Coffin, SG Lim, PJ Chen, HLA Janssen, P Marcellin, L Serfaty, S Zeuzem, D Cohen, L Critelli, D Xu, M Wind-Rotolo, E Cooney, and the LIRA-B study team. Peginterferon lambda for the treatment of HBeAg-positive chronic hepatitis: a randomized phase 2b study (LIRA-B). J Hepatol 2016;64:1011-9.
  6. VWS Wong, GLH Wong, JCL Yeung, CYK Fung, JKL Chan, ZHY Chang, CTY Kwan, HW Lam, J Limquiaco, AML Chim, HLY Chan. Long-term clinical outcomes after fatty liver screening in patients undergoing coronary angiogram: a prospective cohort study. Hepatology 2016;63:754-63.
  7. P Marcellin, SH Ahn, X Ma, FA Caruntu, WY Tak, M Elkashab, WL Chuang, SG Lim, F Tabak, R Mehta, J Petersen, GR Foster, L Lou, EB Martins, P Dinh, A Corsa, P Charuworn, GM Subramanian, H Reiser, HW Reesink, S Fung, SI Strasser, H Trinh, M Buti, GB Gaeta, AJ Hui, G Papatheodoridis, R Flisiak, HLY Chan, on behalf of the study 149 investigators. Combination of tenofovir disoproxil fumarate and peginterferon alfa-2a increases loss of hepatitis B surface antigen in patients with chronic hepatitis B. Gastroenterology 2016;150:134-44.
  8. Y Tian, VWS Wong, GLH Wong, W Yang, H Sun, J Shen, JH Tong, MY Go, YS Cheung, PB Lai, M Zhou, G Xu, YH Huang, J Yu, KF To, ASF Cheng, HLY Chan. Histone deacetylase HDAC8 promotes insulin resistance and β-catenin activation in NAFLD-associated hepatocellular carcinoma. Cancer Res 2015;75:4803-16.
  9. VWS Wong, GLH Wong, DKW Yeung, TKT Lau, CKM Chan, AML Chim, JM Abrigo, RSM Chan, J Woo, YK Tse, WCW Chu, HLY Chan. Incidence of non-alcoholic fatty liver disease in Hong Kong: a population study with paired proton-magnetic resonance spectroscopy. J Hepatol 2015;62:182-9.
  10. HLY Chan, CK Chan, AJ Hui, S Chan, F Poordad, TT Chang, P Mathurin, JF Flaherty, L Lin, A Corsa, A Gaggar, GM Subramanian, JG McHutchison, S Lee, EJ Gane. Effects of tenofovir disoproxil fumarate in hepatitis B e antigen-positive patients with normal levels of alanine aminotransferase and high levels of hepatitis B virus DNA. Gastroenterology 2014;146:1240-8.
Programme Director, Master of Science in Gastroenterology
Supervisor of MPhil and PhD students in Medical Sciences
Lecturer, Diploma in Advances in Medicine