Research



Professor LO Yuk Ming, Dennis, SBS, JP

Research - Associate Dean

Chairman of the Department of Chemical Pathology
Professor of Chemical Pathology
Director of the Li Ka Shing Institute of Health Sciences
Li Ka Shing Professor of Medicine

Research - Associate Dean

Professor LO Yuk Ming, Dennis, SBS, JP

Department of Chemical Pathology

Contact Information
Office : (852) 3763-6001
Email : loym@cuhk.edu.hk


School / Department / Institute / Centre / Unit
Department of Chemical Pathology

Expertise
Genetics and medicine, DNA testing and other aspects of chemical pathology

Education
BA (Hons), University of Cambridge (1986)
BM BCh, University of Oxford (1989)
MA, University of Cambridge (1990)
DPhil, University of Oxford (1994)
DM, University of Oxford (2001)

Research Interests
Molecular diagnostics, non-invasive prenatal diagnosis, cancer biomarkers

Additional information
Fellow of Royal Society
Foreign Associate, United States National Academy of Sciences
Fellow, The World Academy of Sciences
Founding Fellow, The Academy of Sciences of Hong Kong
Laureate of Future Science Prize - Life Science 2016
Laureate of King Faisal International Prize in Medicine 2014
Honorary Fellow, Emmanuel College, University of Cambridge, United Kingdom
Thomson Reuters Citation Laureate - Chemistry
Honorary Fellow, Royal College of Obstetricians and Gynaecologists
 
Selected Publications

  1. Lam WKJ, Jiang P, Chan KCA, Cheng SH, Zhang H, Peng W, Tse OYO, Tong YK, Gai W, Zee BCY, Ma BBY, Hui EP, Chan ATC, Woo JKS, Chiu RWK, Lo YMD (2018). Sequencing-based counting and size profiling of plasma Epstein-Barr virus DNA enhance population screening of nasopharyngeal carcinoma. Proc Natl Acad Sci USA 115(22), E5115-E5124.
  2. Sun K, Jiang P, Wong AIC, Cheng YKY, Cheng SH, Zhang H, Chan KCA, Leung TY, Chiu RWK, and Lo YMD (2018). Size-tagged preferred ends in maternal plasma DNA shed light on the production mechanism and show utility in noninvasive prenatal testing. Proc Natl Acad Sci USA 115(22), E5106-E5114.
  3. Tsang JCH, Vong JSL, Ji L, Poon LCY, Jiang P, Lui KO, Ni YB, To KF, Cheng YKY, Chiu RWK, Lo YMD (2017). Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics. Proc Natl Acad Sci USA 114(37): E7786-E7795.
  4. Chan KCA, Woo JKS, King A, Zee BCY, Lam WKJ, Chan SL, Chu SWI, Mak C, Tse IOL, Leung SYM, Chan G, Hui EP, Ma BBY, Chiu RWK, Leung SF, van Hasselt AC, Chan ATC, Lo YMD (2017). Analysis of Plasma Epstein-Barr Virus DNA to Screen for Nasopharyngeal Cancer. N Engl J Med 377(6):513-522.
  5. Chan KCA, Jiang P, Sun K, Cheng YKY, Tong YK, Cheng SH, Wong AIC, Hudecova I, Leung TY, Chiu RWK, Lo YMD (2016). Second generation noninvasive fetal genome analysis reveals de novo mutations, single-base parental inheritance, and preferred DNA ends. Proc Natl Acad Sci USA 113(50):E8159-E8168.
  6. Sun K, Jiang P, Chan KCA, Wong J, Cheng YKY, Liang RHS, Chang WK, Ma ESK, Chan SL, Cheng SH, Chan RWY, Tong YK, Ng SSM, Wong RSM, Hui DSC, Leung TN, Leung TY, Lai PBS, Chiu RWK, Lo YMD (2015). Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments. Proc Natl Acad Sci USA 112(40):E5503-E5512.
  7. Jiang P, Chan CWM, Chan KCA, Cheng SH, Wong J, Wong VWS, Wong GLH, Chan SL, Mok TSK, Chan HLY, Lai PBS, Chiu RWK, Lo YMD (2015). Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients. Proc Natl Acad Sci USA 112(11):E1317-E1325.
  8. Yu SCY, Chan KCA, Zheng YWL, Jiang P, Liao GJW, Sun H, Akolekar R, Leung TY, Go ATJI, van Vugt JMG, Minekawa R, Oudejans CBM, Nicolaides KH, Chiu RWK, Lo YMD (2014). Size-based molecular diagnostics using plasma DNA for noninvasive prenatal testing. Proc Natl Acad Sci USA 111(23):8583-8588.
  9. Lo YMD, Chan KCA, Sun H, Chen EZ, Jiang P, Lun FMF, Zheng YW, Leung TY, Lau TK, Cantor CR, Chiu RWK (2010). Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus. Sci Transl Med 2:61ra91.
  10. Lo YMD, Lun FMF, Chan KCA, Tsui NBY, Chong KC, Lau TK, Leung TY, Zee BC, Cantor CR, Chiu RWK (2007). Digital PCR for the molecular detection of fetal chromosomal aneuploidy. Proc Natl Acad Sci USA 104:13116-13121.
  11. Ng EKO, Tsui NBY, Lau TK, Leung TN, Chiu RWK, Panesar NS, Lit LCW, Chan KW, Lo YMD (2003). mRNA of placental origin is readily detectable in maternal plasma. Proc Natl Acad Sci USA 100(8):4748-4753.
  12. Lo YMD, Chan LYS, Lo KW, Leung SF, Zhang J, Chan ATC, Lee JC, Hjelm NM, Johnson PJ, Huang DP (1999). Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma. Cancer Res 59:1188-1191.
  13. Lo YMD, Zhang J, Leung TN, Lau TK, Chang AM, Hjelm NM (1999). Rapid clearance of fetal DNA from maternal plasma. Am J Hum Genet 64:218-224.
  14. Lo YMD, Tein MS, Lau TK, Haines CJ, Leung TN, Poon PM, Wainscoat JS, Johnson PJ, Chang AM, Hjelm NM (1998). Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis. Am J Hum Genet 62:768-775.
  15. Lo YMD, Hjelm NM, Fidler C, Sargent IL, Murphy MF, Chamberlain PF, Poon PM, Redman CW, Wainscoat JS (1998). Prenatal diagnosis of fetal RhD status by molecular analysis of maternal plasma. N Engl J Med 339:1734-1738.
  16. Lo YMD, Corbetta N, Chamberlain PF, Rai V, Sargent IL, Redman CW, Wainscoat JS (1997). Presence of fetal DNA in maternal plasma and serum. Lancet 350:485-487.
Bachelor of Medicine and Bachelor of Surgery (MBChB) Programme
MPhil in Chemical Pathology
PhD in Chemical Pathology