Research

Professor LO Yuk Ming, Dennis

Research - Associate Dean

Chairman of the Department of Chemical Pathology
Professor of Chemical Pathology
Director of the Li Ka Shing Institute of Health Sciences
Li Ka Shing Professor of Medicine

Research - Associate Dean

Professor LO Yuk Ming, Dennis

Department of Chemical Pathology

Contact Information
Office : (852) 3763-6001
Email : loym@cuhk.edu.hk


School / Department / Institute / Centre / Unit
Department of Chemical Pathology

Expertise
Genetics and medicine, DNA testing and other aspects of chemical pathology

Education
BA (Hons), University of Cambridge (1986)
BM BCh, University of Oxford (1989)
MA, University of Cambridge (1990)
DPhil, University of Oxford (1994)
DM, University of Oxford (2001)

Research Interests
Molecular diagnostics, non-invasive prenatal diagnosis, cancer biomarkers

Additional information
Laureate of Future Science Prize - Life Science 2016
Laureate of King Faisal International Prize in Medicine 2014
Honorary Fellow, Emmanuel College, University of Cambridge, United Kingdom
Founding Fellow, The Academy of Sciences of Hong Kong
Fellow of Royal Society
Foreign Associate, United States National Academy of Sciences
Fellow, The World Academy of Sciences
 
Selected Publications
  1. Lo YMD, Lun FMF, Chan KCA, Tsui NBY, Chong KC, Lau TK, Leung, TY, Zee, BC, Cantor, CR, Chiu, RW. Digital PCR for the molecular detection of fetal chromosomal aneuploidy. Proceedings of the National Academy of Sciences of the United States of America 2007; 104: 13116-13121.
  2. Chim SSC, Shing TK, Hung ECW, Leung TY, Lau TK, Chiu RWK, Lo YMD. Detection and characterization of placental microRNAs in maternal plasma. Clinical Chemistry 2008; 54: 482-490.
  3. Lun FM, Tsui NB, Chan KC, Leung TY, Lau TK, Charoenkwan P, Chow KC, Lo WY, Wanapirak C, Sanguansermsri T, Cantor CR, Chiu RW, Lo YMD. Noninvasive prenatal diagnosis of monogenic diseases by digital size selection and relative mutation dosage on DNA in maternal plasma. Proceedings of the National Academy of Sciences of the United States of America 2008; 105: 19920-19925.
  4. Chiu RW, Chan KC, Gao Y, Lau VY, Zheng W, Leung TY, Foo CH, Xie B, Tsui NB, Lun FM, Zee BC, Lau TK, Cantor CR, Lo YMD. Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel sequencing of maternal plasma DNA. Proceedings of the National Academy of Sciences of the United States of America 2008; 105: 20458-20463.
  5. Lo YMD, Chan KC, Sun H, Chen EZ, Jiang P, Lun FM, Zheng YW, Leung TY, Lau TK, Cantor CR, Chiu RW. Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus. Science Translational Medicine 2010; 2: 61ra91.
  6. Chiu RW, Akolekar R, Zheng YW, Leung TY, Sun H, Chan KC, Lun FM, Go AT, Lau ET, To WW, Leung WC, Tang RY, Au-Yeung SK, Lam H, Kung YY, Zhang X, van Vugt JM, Minekawa R, Tang MH, Wang J, Oudejans CB, Lau TK, Nicolaides KH, Lo YMD. Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study. British Medical Journal 2011; 342: c7401.
  7. Chan KC, Jiang P, Chan CW, Sun K, Wong J, Hui EP, Chan SL, Chan WC, Hui DS, Ng SS, Chan HL, Wong CS, Ma BB, Chan AT, Lai PB, Sun H, Chiu RW, Lo YMD. Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing. Proceedings of the National Academy of Sciences of the United States of America 2013; 110: 18761-18768.
  8. Yu SCY, Chan KCA, Zheng YW, Jiang P, Liao GJ, Sun H, Akolekar R, Leung TY, Go AT, van Vugt JM, Miekawa R, Oudejans CBM, Nicolaides KH, Chiu RWK, Lo YMD. Size-based molecular diagnostics using plasma DNA for noninvasive prenatal testing.Proceedings of the National Academy of Sciences of the United States of America 2014; 111: 8583-8588.
  9. Chan RW, Jiang P, Peng X, Tam LS, Liao GJ, Li EK, Wong PC, Sun H, Chan KCA, Chiu RWK, Lo YMD. Plasma DNA aberrations in systemic lupus erythematosus revealed by genomic and methylomic sequencing. Proceedings of the National Academy of Sciences of the United States of America 2014; 111: E5302-5311.
  10. Jiang P, Chan CWM, Chan KCA, Cheng SH, Wong J, Wong VWS, Wong GLH, Chan SL, Mok TSK, Chan HLY, Lai PBS, Chiu RWK, Lo YMD. Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients. Proceedings of the National Academy of Sciences of the United States of America 2015; 112: E1317-1325.
Bachelor of Medicine and Bachelor of Surgery (MBChB) Programme
MPhil in Chemical Pathology
PhD in Chemical Pathology