Research



Professor LAN Hui Yao

Research - Assistant Dean

​Associate Director, Li Ka Shing Institute of Health Sciences
Choh-Ming Li Professor of Biomedical Sciences; Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences

Research - Assistant Dean

Professor LAN Hui Yao

Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences

Contact Information
Office : (852) 3763-6077
Email : hylan@cuhk.edu.hk


School / Department / Institute / Centre / Unit
Department of Medicine and Therapeutics
Li Ka Shing Institute of Health Sciences

Expertise
Immunopathology and molecular pathology

Education
MB,BS, Sun Yet-Sen University of School of Medicine (July 1977);
M.Med, Sun Yet-Sen University of School of Medicine (July 1982);
PhD, Monash University (1991)

Academic Qualifications
MB,BS; MMed; PhD

Research Interests
1. TGF-beta/Smad signaling pathway in kidney and cardiovascular diseases
2. TGF-beta/Smad signaling pathway in tumor microenvironments

Additional Information
Associate Director, Li Ka Shing Institute of Health Sciences
Chairman of Animal Experimentation Ethics Committee, CUHK
Assembly Fellow and Chairman of International Student Exchange Committee, Lee Woo Sing College, CUHK.
Vice President, Chinese Society of Renal Physiology
Associate Editor, Clinical Experimental Pharmacology and Physiology, Frontier in Physiology, J Cellular and Molecular medicine
Editorial Board members: J Am Soc Nephrol,Mol Ther, Int J Biol Sci, Sci Rep, Kid Dis

Recent Honours and Awards
Chan Woon Cheung Memorial Fund Award, Hong Kong Society of Nephrology, 2010 
Choh-Ming Li Professor of Biomedical Sciences, The Chinese University of Hong Kong, 2014
The Second-class MOE Higher Education Outstanding Scientific Research Output Award (Natural Sciences Award), Ministry of Education, 2014
Rain Visiting Professorship Award, University of Western Australia, 2014
The 1st Prize in Chinese Medical Science and Technology Award, 2015
The 2nd Prize for National Science and Technology Progress Award, 2016

 
 
Selected Publications
(https://scholar.google.com/citations?hl=en&view=&user=6cC_60cAAAAJ)  

  1. Wang W, Huang XR, Canlas E, Oka K, Truong LD, Deng C, Bhowmick NA, Ju W, Bottinger EP, Lan HY: Essential role of Smad3 in Angiotensin II-Induced Vascular Sclerosis. Circ. Res. 98:1032-9, 2006.
  2. Koka V, Wang W , Huang XR , Kim-Mitsuyama S, Truong LD, Lan HY: Advanced Glycation End Products Activate a Chymase-Dependent Angiotensin II Generating Pathway in Diabetic Complications. Circulation 113(10):1353-60, 2006.
  3. Chung AC, Huang XR, Meng X, Lan HY. miR-192 Mediates TGF-{beta}/Smad3-Driven Renal Fibrosis. J Am Soc Nephrol. 21: 1317-1325,2010.
  4. Meng X, Huang XR, Chung ACK, Shao X, Igarashi P, Ju W, Berttinger E, Lan HY: Smad2 protects against TGF-/Smad3-mediated extracellular matrix production and renal fibrosis in vitro and in vivo. J Am Soc Nephrol 21:1477-87, 2010.
  5. Chen H, Huang XR, Wang W, Li J, Heuchel RL, Chung AC, Lan HY. The Protective Role of Smad7 in Diabetic Kidney Disease: Mechanism and Therapeutic Potential. Diabetes. 60:590-601, 2011.
  6. Qin W, Chung AC, Huang XR, Meng XM, Hui DS, Yu CM, Sung JJ, Lan HY. TGF-{beta}/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29. J Am Soc Nephrol. 22:1462-1474, 2011.
  7. Zhong X, Chung AC, Chen HY, Meng XM, Lan HY. Smad3-Mediated Upregulation of miR-21 Promotes Renal Fibrosis. J Am Soc Nephrol. 22:1668-81, 2011.
  8. Meng XM, Huang XR, Xiao J, Chung AC, Qin W, Lan HY. Disrupted Smad4 impairs TGF-/Smad3 and Smad7 transcriptional regulation in renal inflammation and fibrosis in vivo and in vitro. Kidney Int 81:266-79, 2012.
  9. Wang YY, Jiang H, Pan J, Huang XR, Wang YC, Huang HF, To KF, Nikolic-Paterson DJ, Lan HY, Chen JH. Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury. J Am Soc Nephrol. 28(7):2053-2067, 2017.
  10. Tang PM, Zhou S, Meng XM, Wang QM, Li CJ, Lian GY, Huang XR, Tang YJ, Guan XY, Yan BP, To KF, Lan HY. Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development. Nat Commun.8:14677, 2017.
  11. Sun SF, Tang PMK, Feng M, Xiao J, Huang XR, Li P, Ma RCW, Lan HY. Novel lncRNA Erbb4-IR Promotes Diabetic Kidney Injury in db/db Mice by Targeting miR-29b. Diabetes. 67(4):731-744, 2018.
  12. Tang PM, Zhou S, Li CJ, Liao J, Xiao J, Wang QM, Lian GY, Li J, Huang XR, To KF, Ng CF, Chong CC, Ma RC, Lee TL, Lan HY. The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring. Kidney Int.93(1):173-187, 2018.
PhD Programs in Inflammatory Diseases and Cancer microenvironments