School Directors



Professor CHAN Wai Yee

Professor and Acting Director, School of Biomedical Sciences

Professor CHAN Wai Yee

School of Biomedical Sciences

Contact Information
Office : (852) 3943-1383
Email : chanwy@cuhk.edu.hk


Expertise
Molecular and biochemical genetics, genomics, functional genomics, epigenetics and epigenomics, bioinformatics

Education
1970-74 BSc (Hon, 1st Class), Chemistry, The Chinese University of Hong Kong, Hong Kong,
PhD, Biochemistry, University of Florida, Gainesville, Florida, USA.
Genetics Fellowship, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

Research Interests
The molecular genetics of human reproductive and endocrine disorders, biochemical genetics of inborn errors of trace element metabolism, functional genomics and epigenomics of germinal stem cells and reproductive tumors, and non-coding RNAs in the differentiation of human induced pluripotent stem cells (iPSCs).
 
Selected Publications
  1. Chan WY, Cushing W, Coffman MA, Rennert OM. Genetic expression of Wilson's Disease in cell culture: A diagnostic marker. Science. 208:299-300, 1980.
  2. Chan WY, Liu QR, Borjigin J, Busch H, Rennert OM, Tease LA, Chan PK. Characterization of a cDNA encoding human nucleophosmin and studies of its function in normal and abnormal growth. Biochemistry. 28(3):1033-1039, 1989.
  3. Laue L, Wu SM, Kudo M, Hsueh AJW, Griffin JE, Wilson JD, Grant DB, Brain C, Berry EC, Cutler GB Jr, Chan WY. Nonsense mutation of the human luteinizing hormone receptor gene in Leydig cell hypoplasia. Hum Mol Genet. 4:1429-1433, 1995.
  4. Laue L, Wu SM, Kudo M, Bourdony CJ, Cutler GB JR, Hsueh AJW, Chan WY. Compound heterozygous mutations of the LH receptor gene in Leydig cell hypoplasia. Mol Endocrinol. 10:987-997, 1996.
  5. Lee TL, Cheung HH, Claus J, Sastry C, Singh S, Vu L, Rennert OM, Chan WY. GermSAGE: A comprehensive SAGE database for transcript discovery on male germ cell development. Nucl Acid Res, 2009 Jan; 37:D891-897. Epub 2008 Oct 2.
  6. Cheung HH, Lee TL, Davis AJ, Taft DH, Rennert OM, Chan WY. Genome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non-coding RNAs in human testicular cancer. Brit J Cancer, 102(2):419-427, 2010.
  7. Cheung H, Davis, AJ, Lee TL, Pang AL, Nagrani S, Rennert OM, Chan WY. Methylation of an intronic region regulates testicular cancer invasiveness via miR-199a. Oncogene, 30(31):3405-3415, 2011.
  8. Chen X, Gu S, Chen BF, Shen WL, Yin Z, Xu GW, Hu JJ, Zhu T, Li G, Wan C, Ouyang HW, Lee TL, Chan WY. Nanoparticle delivery of stable miR-199a-5p agomir improves the osteogenesis of human mesenchymal stem cells via the HIF1a pathway. Biomaterials, 53:239-250, 2015.
  9. Tu JJ, Cao DD, Cheung HH, Chan WY. The role of microRNA during directed differentiation of cortical interneurons from human induced pluripotent stem cells. FEBS Open Bio. 17;8(4):502-512, 2018.
  10. Li L, Miu KK, Gu S, Cheung HH, Chan WY. Comparison of multi-lineage differentiation of hiPSCs reveals novel miRNAs that regulate lineage specification. Sci Rep, 8:9630, 2018.
Pro-Vice Chancellor/ Vice President
Master, CW Chu College