Professor CHAN Ka Leung, Francis, JP


Choh-Ming Li Professor of Medicine and Therapeutics
Director, Centre for Gut Microbiota Research


Professor CHAN Ka Leung, Francis, JP

Department of Medicine and Therapeutics

Contact Information
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School / Department / Institute / Centre / Unit
Department of Medicine and Therapeutics

Peptic ulcer bleeding, helicobacter pylori, endoscopic therapy, colorectal cancer

1988 MBChB (Hons), CUHK
1998 MD, CUHK
2011 DSc, CUHK

Professional Qualifications
1995 Fellow of the Hong Kong College of Physicians (Gastroenterology & Hepatology)
1995 Fellow of the Hong Kong Academy of Medicine (Medicine)
1999 Fellow of the Royal College of Physicians of Ireland
2000 Fellow of the Royal College of Physicians of Edinburgh 
2003 Fellow of the American College of Gastroenterology
2004 Fellow of the Royal College of Physicians of London
2018 Honorary Fellow of Internal Medicine, Royal College of Physicians of Thailand

Research Interests
Peptic ulcer bleeding, helicobacter pylori, endoscopic therapy and colorectal cancer

Additional Information
Honours and Awards (National and International)
2005 David Y. Graham Lecturer (The American College of Gastroenterology)
2007 The State Scientific and Technological Progress Award (National Office for Science and Technology Awards, PRC)
2008 Andy Martynoga Memorial Lecturer
2007-08 Croucher Senior Medical Research Fellowship
2011 JGHF Marshall and Warren Lecturer
2016 19th Vikit Viranuvatti’s Lecturer
2018 2018 International Leadership Award (The American College of Gastroenterology)

Service Statutory Bodies
Board Member Hong Kong Hospital Authority
Member   Colorectal Cancer Screening Pilot Programme Task Force, Department of Health
Permanent Member Expert Panel of Central Research Working Group for Hospital Authority, Chinese Medicine Research, Hong Kong Hospital Authority
Member Governing Board, Hong Kong Jockey Club Disaster Preparedness and Response Institute, Hong Kong Academy of Medicine
Convenor Endoscopy Task Force of Project Steering Committee on Standards for Ambulatory Facilities, Department of Health
Ex-officio Member Research Fellowship Assessment Panel, Food and Health Bureau

Other Service (Profession and Community)
Member, External Review Committee, Hong Kong Sanatorium & Hospital (Oct 2017 – Sep 2020)
Honorary Advisor, Hong Kong Association for Integration of Chinese-Western Medicine (Dec 2017 – present)
Advisor on Education, Peking Union Medical College (PUMC) (Sept 2012 – present)
Assessment  Expert of Health Research Projects, Technology Education Unit of Ministry of Health, People’s Republic of China (Mar 2013 – Feb 2016)
Panelist, Global Panel of Clinicians and Clinical Researchers, Nature [to help Nature select a list of high-quality clinical journals for inclusion in the Nature Index] (Feb 2016 – present)
Nominator, 2016 Future Science Prize, Beijing, China
External Assessor in Gastroenterology, University of Malaya, Malaysia (Mar 2016 – present)
Leader, Task Force for Developing Clinical Practice Guidelines for Clinicians in Asia Pacific Countries, appointed by Asian Pacific Association of Gastroenterology and the Asian Pacific Society of Digestive Endoscopy (May 2016 – present)
Member, Open Fund Large Collaborative Grant Review Panel, National Medical Research Council, Ministry of Health, Singapore (Jul 2018 – Apr 2021)

Brief CV
Selected Publications

Professor Chan has published more than 500 full scientific articles in high impact factor international journals such as New England Journal of Medicine, Lancet and Gastroenterology with an H-index 94.
  1. Chan FK, et al. Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): an industry-independent, double-blind, double-dummy, randomised trial. Lancet 2017;389:2375-82.
  2. Chan FK, et al. Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): arandomised trial. Lancet 2010;376:173-9.
  3. Chan FK, et al. Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial. Lancet 2007;369:1621-6.
  4. Chan FK, et al. Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. N Engl J Med 2005;352:238-44.
  5. Chan FK, et al. Eradication of Helicobacter pylori and the risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: A randomised trial. Lancet 2002;359:9-13.
  6. Chan FK, et al. Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis. N Engl J Med 2002;347:2104-10.
  7. Chan FK, et al. Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen. N Engl J Med 2001;344:967-73.
  8. Chan FK, et al. Randomised trial of eradication of Helicobacter pylori before non-steroidal anti-inflammatory drug therapy to prevent peptic ulcers. Lancet 1997;350:975-97.