Dr CHOW Yee Kwan, Elaine
Assistant Dean (Health Systems)
Associate Professor (Clinical), Department of Medicine and Therapeutics
CUHK Employment
- Assistant Dean (Health Systems)
- Associate Professor (Clinical), Department of Medicine and Therapeutics
External Affairs Strategic Director, Phase 1 Clinical Trial Centre
Expertise
- Clinical Pharmacology
- Cardiovascular Renal-Metabolic disease
- Clinical trials
Education & Qualifications
LMCHK, MRCP (UK), FHKCP, FHKAM (Medicine), FRCP (Lond)
Research Interests
- Novel drugs and personalised therapeutics in diabetes and prediabetes
- Continuous glucose monitoring (CGM) and wearable technologies
-sensor evaluation and application in populations including advanced diabetic kidney disease and prediabetes - Glucose clamp studies in diabetic and nondiabetic populations (hyperglycemic, hypoglycemic,
- Pharmacoepidemiology and real world evidence in cardiometabolic diseases
Additional Information
Award and Honour
Sir David Todd Lecture, Hong Kong College of Physicians, 2024
Richard Yu Lecture, Hong Kong College of Physicians, 2022
Women’s Interprofessional Network Abstract Award (Clinical Diabetes), American Diabetes Association, 2022
Young Investigator Award, Hong Kong College of Physicians, 2021 and 2019
Professional Service
- Associate Editor, Diabetes Clinical Research Practice
Editorial Board member, Diabetes & Metabolism Journal
Editorial Board, Communications Medicine
Member of Technology and AI Working Group, International Diabetes Federation
Academic Engagement in CUHK
- Teaching Coordinator, MEDU3110 Junior Medical Clerkship
- Student Exchange Committee
Selected Publications
Researcher ID: https://orcid.org/0000-0002-4147-3387
- Chu, NHS., Ling, J., Poon, EWM., Lee, J., Song, Q., Zuo, Z., Muir, J., Chan, JCN., Chow, E.*, 2025. Combining a diet rich in fermentable carbohydrates with metformin improves glycaemic control and reshapes the gut microbiota in people with prediabetes. Nature Metabolism 7, 1614–1629.. https://doi.org/10.1038/s42255-025-01336-4
- Shi M, Yang A, Lau ESH, Luk AOY, Ma RCW, Kong APS, Wong RSM, Chan JCM, Chan JCN, Chow E*. A novel electronic health record-based, machine-learning model to predict severe hypoglycemia leading to hospitalizations in older adults with diabetes: A territory-wide cohort and modeling study. PLoS Medicine. 2024;21(4). https://doi.org/10.1371/journal.pmed.1004369
- Yang A, Shi M, Lau ESH, Wu H, Zhang X, Fan B, Kong APS, Luk AOY, Ma RCW, Chan JCN, Chow E*. Clinical outcomes following discontinuation of renin-angiotensin-system inhibitors in patients with type 2 diabetes and advanced chronic kidney disease: A prospective cohort study. eClinicalMedicine. 2023;55.
https://doi.org/10.1016/j.eclinm.2022.101751 - Ng JL, J; Luk, AOY; Lau, ESH; Ma, RCW; Li, PTK; Szeto, CC; Chan, JCN; Chow, E*. Evaluation of a Fourth-Generation Subcutaneous Real-time Continuous Glucose Monitor (CGM) in Individuals with Diabetes on Peritoneal Dialysis. Diabetes Care. 2023;46(6): https://doi.org/10.2337/dc22-2348
- Chow E*, Wang K, Lim K, Tsoi S, Fan B, Poon E, Luk A, Ma R, Ferrannini E, Mari A, Chen L, Chan J. Dorzagliatin, a dual-acting glucokinase activator, increases insulin secretion and glucose sensitivity in glucokinase-maturity-onset diabetes of the young (GCK-MODY) and recent-onset type 2 diabetes. Diabetes 2023;72(2):299–308
https://doi.org/10.2337/db22-0708 - Lim LL, Chow E, Chan JCN. Cardiorenal diseases in type 2 diabetes mellitus: clinical trials and real-world practice. Nat Rev Endocrionol,2023; 19, 151–163.
https://doi.org/10.1038/s41574-022-00776-2 - Battelino T, Alexander CM, Amiel SA, Arreaza-Rubin G, Beck RW, Bergenstal RM, Buckingham BA, Carroll J, Ceriello A, Chow E, Choudhary P, Close K, Danne T, Dutta S, Gabbay R, Garg S, Heverly J, Hirsch IB, Kader T, Kenney J, Kovatchev B, Laffel L, Maahs D, Mathieu C, Mauricio D, Nimri R, Nishimura R, Scharf M, Del Prato S, Renard E, Rosenstock J, Saboo B, Ueki K, Umpierrez GE, Weinzimer SA, Phillip M. Continuous glucose monitoring and metrics for clinical trials: an international consensus statement. Lancet Diabetes Endocrinol. 2023;11(1):42-57. doi: 10.1016/s2213-8587(22)00319-9.
- Yang A, Shi M, Wu H, Lau ESH, Ma RCW, Kong APS, So WY, Luk AOY, Chan JCN, Chow E*. Long-term metformin use and risk of pneumonia and related death in type 2 diabetes: a registry-based cohort study. Diabetologia. 2021;64(8):1760-5.
https://doi.org/10.1007/s00125-021-05452-0 - Yang A, Wu H, Lau ESH, Ma RCW, Kong APS, So WY, Luk AOY, Chan JCN, Chow E*. Trends in glucose-lowering drug use, glycemic control, and severe hypoglycemia in adults with diabetes in Hong Kong, 2002–2016. Diabetes Care 2020;43:2967-2974.
https://doi.org/10.2337/dc20-0260 - Chow E, Bernjak A, Williams S, Fawdry S, Hibbert S, Freeman J, Sheridan PJ, Heller SR.. Risk of cardiac arrhythmias during hypoglycemia in patients with type 2 diabetes and cardiovascular risk. Diabetes 2014; 63(5): 1738-1747
https://doi.org/10.2337/db13-0468