- Associate Dean (External Affairs), Faculty of Medicine
- Director, Office of Global Engagement, Faculty of Medicine
- Professor, Department of Medicine and Therapeutics
- Director, Centre for Liver Health
- Associate Head, Shaw College
- Gastroenterology and Hepatology
Education & Qualifications
MBChB (CUHK), MD (CUHK), FRCP (Edin), FRCP (Lond), FHKCP, FHKAM (Med), FAASLD
- Viral hepatitis
- Liver fibrosis
- Liver cancer
- Anti-viral therapy
- Fatty liver disease
Award & Honour
- Highly Cited Researcher (Cross Field), Clarivate Analytics, 2018
- Honorary Visiting Professor, Ludwig-Maximilians-Universtat Munchen (University of Munich), 2018
- Guangdong Province Science & Technology Award - First-class Award, 2018
- Okuda Lectureship Award, Asia Pacific Digestive Week, 2018
- Chainuvati Lecturer, Thai Association for the Study of the Liver, Thailand, 2018
- Excellent Research Award, Food and Health Bureau, Hong Kong, 2014
- National Award for Science and Technology Progress 2012 - Second-class, 2012
- MoE Higher Education Outstanding Scientific Research Output Award (Scientific and Technological Progress Award) - First-class, Ministry of Education, 2012
- Sir David Todd Lectureship, Hong Kong College of Physicians, 2011
- Croucher Senior Medical Research Fellowship, The Croucher Foundation, Hong Kong, 2011
- JGH Emerging Leader Lectureship Award, Asia Pacific Digestive Week, 2010
- Excellent Research Award (Clinical Studies), Food and Health Bureau, Hong Kong, 2010
- Association of Southeast Asian Institutions of Higher Learning -Scopus Young Scientist Award, 2008
- Distinguished Research Paper Award for Young Investigators, Hong Kong College of Physicians, 2008
- Young Investigator Award, Asian Pacific Association for the Study of the Liver, 2008
- Ten Outstanding Young Persons Award, Hong Kong, 2008
- Chairman, Strategic Technical Advisory Committee for Viral Hepatitis, Western Pacific Regional Office of World Health Organization
Council member, Hong Kong Association for the Study of Liver Diseases
Deputy Chief of Service, Department of Medicine and Therapeutics, Prince of Wales Hospital
- Associate editor, Hepatology International
- Associate editor, Seminar of Liver Diseases
Academic Engagement in CUHK
- Programme Director, Certificate in Professional Medical Communication
- Associate Programme Director, Master of Science in Gastroenterology
- Supervisor, MPhil and PhD in Medical Sciences
- Lecturer, Diploma in Advances in Medicine
- VWS Wong, GLH Wong, RS Chan, SST Shu, BH Cheung, LS Li, AML Chim, CK Chan, JK Leung, WCW Chu, J Woo, HLY Chan. Beneficial effects of lifestyle intervention in non-obese patients with non-alcoholic fatty liver disease. J Hepatol 2018;69:1349-56.
- K Agarwal, M Brunetto, WK Seto, YS Lim, S Fung, P Marcellin, SH Ahn, N Izumi, WL Chuang, H Bae, M Sharma, HLA Janssen, CQ Pan, M Celen, N Furusyo, Shalimar, KT Yoon, H Trinh, JF Flaherty, A Gaggar, A Lau, AL Cathcart, L Lin, N Bhardwaj, V Suri, GM Subramanian, E Gane, M Buti, HLY Chan. 96 weeks treatment of tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of chronic hepatitis B virus infection. J Hepatol 2018;68:672-81.
- TCF Yip, GLH Wong, VWS Wong, YK Tse, GCY Lui, KLY Lam, HLY Chan. Durability of hepatitis B surface antigen seroclearance in untreated and nucleos(t)ide analogue-treated patients. J Hepatol 2018;68:63-72.
- HLY Chan, S Fung, WK Seto, WL Chuang, CY Chen, HJ Kim, AJ Hui, HLA Janssen, A chowdhury, TY Tsang, R Mehta, E Gane, JF Flaherty, B Massetto, A Gaggar, KM Kitrinos, L Lin, GM Subramanian, JG McHutchison, YS Lim, SK Acharya, K Agarwal, GS-US-320-0110 investigators. Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection: a randomized, double-blind, phase 3, non-inferiority trial. Lancet Gastroenterol Hepatol 2016;1:185-95.
- HLY Chan, SH Ahn, TT Chang, CY Peng, D Wong, CS Coffin, SG Lim, PJ Chen, HLA Janssen, P Marcellin, L Serfaty, S Zeuzem, D Cohen, L Critelli, D Xu, M Wind-Rotolo, E Cooney, and the LIRA-B study team. Peginterferon lambda for the treatment of HBeAg-positive chronic hepatitis: a randomized phase 2b study (LIRA-B). J Hepatol 2016;64:1011-9.
- VWS Wong, GLH Wong, JCL Yeung, CYK Fung, JKL Chan, ZHY Chang, CTY Kwan, HW Lam, J Limquiaco, AML Chim, HLY Chan. Long-term clinical outcomes after fatty liver screening in patients undergoing coronary angiogram: a prospective cohort study. Hepatology 2016;63:754-63.
- P Marcellin, SH Ahn, X Ma, FA Caruntu, WY Tak, M Elkashab, WL Chuang, SG Lim, F Tabak, R Mehta, J Petersen, GR Foster, L Lou, EB Martins, P Dinh, A Corsa, P Charuworn, GM Subramanian, H Reiser, HW Reesink, S Fung, SI Strasser, H Trinh, M Buti, GB Gaeta, AJ Hui, G Papatheodoridis, R Flisiak, HLY Chan, on behalf of the study 149 investigators. Combination of tenofovir disoproxil fumarate and peginterferon alfa-2a increases loss of hepatitis B surface antigen in patients with chronic hepatitis B. Gastroenterology 2016;150:134-44.
- Y Tian, VWS Wong, GLH Wong, W Yang, H Sun, J Shen, JH Tong, MY Go, YS Cheung, PB Lai, M Zhou, G Xu, YH Huang, J Yu, KF To, ASF Cheng, HLY Chan. Histone deacetylase HDAC8 promotes insulin resistance and β-catenin activation in NAFLD-associated hepatocellular carcinoma. Cancer Res 2015;75:4803-16.
- VWS Wong, GLH Wong, DKW Yeung, TKT Lau, CKM Chan, AML Chim, JM Abrigo, RSM Chan, J Woo, YK Tse, WCW Chu, HLY Chan. Incidence of non-alcoholic fatty liver disease in Hong Kong: a population study with paired proton-magnetic resonance spectroscopy. J Hepatol 2015;62:182-9.
- HLY Chan, CK Chan, AJ Hui, S Chan, F Poordad, TT Chang, P Mathurin, JF Flaherty, L Lin, A Corsa, A Gaggar, GM Subramanian, JG McHutchison, S Lee, EJ Gane. Effects of tenofovir disoproxil fumarate in hepatitis B e antigen-positive patients with normal levels of alanine aminotransferase and high levels of hepatitis B virus DNA. Gastroenterology 2014;146:1240-8.