Selected Publications

Researcher ID: https://www.webofscience.com/wos/author/record/G-2757-2017

1. Zheng T, Choy KHK, Chan SY, Zheng M, Luo X, Chen H, Xie T, Fok EKL. Extracellular vesicles-mediated transfer of let-7b/7c promotes the proliferation of transition-state spermatogonia in neonatal mouse testis. Stem Cell Reports 2025. Nov 11;20(11):102681. doi: 10.1016/j.stemcr.2025.102681.
2. Li X, Qiao F, Guo J, Jiang T, Lou H, Li H, Xie G, Wu H, Wang W, Pei R, Liu S, Ye M, Li J, Huang S, Zhang M, Ma C, Huang Y, Xu S, Li X, Sun X, Yu J, FOK EKL, Duan S, Chen H. In situ architecture of the intercellular organelle reservoir between epididymal epithelial cells by volume electron microscopy. Nature Communications. 2025. Feb 15;16(1):1664. doi: 10.1038/s41467-025-56807-9.
3. Jin J, Yim HCH*, Chang HME, Wang Y, Choy KHK, Chan SY, OAM Alqawasmeh, Liao J, Jiang X*, Chan DYL*, Fok EKL* (*co-correspondence). DEFB119 stratifies dysbiosis with distorted networks in the seminal microbiome associated with male infertility. PNAS Nexus. 2024 Oct; 3(10):419. doi: 10.1093/pnasnexus/pgae419.
4. Li X#, Yuan C#, Shi J#, Kang H, Chen Y, Duan Y, Jin J, Cheung LP, Li TC, Liu Y, Cui Y, Ruan YC, Jiang X, Cai Z, Chan HC, Liu J*, Zeng X*, Chen H*, Fok KL* (* co-correspondence). β-defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility. Cell Reports Medicine. 2022 Dec 20;3(12):100825. doi: 10.1016/j.xcrm.2022.100825.
5. Choy KHK#, Chan SY#, Lam W#, Zheng T, Law TYS, Yu SS, Wang W, Li L, Xie G, Yim CH, Chen H, Fok KL. The repertoire of testicular extracellular vesicles cargoes and their involvement in inter-compartmental communication associated with spermatogenesis. BMC Biology. 2022 20:(1), 1-16. PMID: 35351114
6. Chen H, Shi X, Li X, Diao R, Ma Q, Jin J, Qiu Z, Li C, Yu MK, Wang C, Li X, Li F, Chan DYL, Zhao AZ, Cai Z, Sun F, Fok KL. CD147 deficiency is associated with impaired sperm motility/acrosome reaction and offers a therapeutic target for asthenozoospermia. Molecular Therapy - Nucleic Acids. 2021 Nov 10;26:1374-1386. doi: 10.1016/j.omtn.2021.11.009.
7. Shi J#, Fok KL#, Dai P#, Qiao F, Zhang M, Liu H, Sang M, Ye M, Liu Y, Zhou Y, Wang C, Sun F*, Xie G*, Chen H* (# equal contributions). Spatial-temporal landscape of mouse epididymal cells and specific mitochondria-rich segment defined by large-scale single-cell RNAseq. Cell Discovery. 2021 May 18;7(1):34. PMID: 34001862
8. Li F, Han J, Cao T, Lam W, Fan B, Tang W, Chen S, Fok KL*, Li L* (* co-correspondence). Design of self-assembly dipeptide hydrogels and machine learning via their chemical features. Proceedings of the National Academy of Sciences. 2019 May 20; 116(23). PMID: 31110004
9. Fok KL#, Bose R#, Sheng K, Chang CW, Katz-Egorov M, Culty M, Su S, Yang M, Ruan YC, Chan HC, Iavarone A, Lasorella A, Cencic R, Pelletier J, Nagano M, Xu W, Wing SS (# Equal contributions). Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response. Endocrinology, 2017 Nov 01; 158(11) 4000-4016. PMID: 28938460
10. Diao R#, Fok KL#, Chen H#, Yu MK, Duan Y, Chung CM, Li Z, Wu H, Li Z, Zhang H, Ji Z, Zhen W, Ng CF, Gui Y, Cai Z, Chan HC (# Equal contributions). Deficient human β-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection. Science Translational Medicine. 2014 Aug 13; 6(249):249ra108. PMID: 25122636.