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Professor LAN Hui Yao

Professor LAN Hui Yao

Associate Dean (Mainland Affairs)

Choh-Ming Li Research Professor of Biomedical Sciences, Department of Medicine and Therapeutics

CUHK Employment
  • Associate Dean (Mainland Affairs), Faculty of Medicine
  • Choh-Ming Li Research Professor of Biomedical Sciences; Department of Medicine and Therapeutics
  • ​Associate Director, Li Ka Shing Institute of Health Sciences
  • Assembly Fellow, Lee Woo Sing College


  • Immunopathology
  • Molecular pathology


Education & Qualifications

MBBS, MMed (SYSU); PhD (Monash)



Research Interests
  • TGF-beta/Smad signaling pathway in kidney and cardiovascular diseases
  • TGF-beta/Smad signaling pathway in tumor microenvironments


Additional Information

Award & Honour

  • The 2nd Prize for National Science and Technology Progress Award, 2016
  • The 1st Prize in Chinese Medical Science and Technology Award, 2015
  • Rain Visiting Professorship Award, University of Western Australia, 2014
  • The Second-class MOE Higher Education Outstanding Scientific Research Output Award (Natural Sciences Award), Ministry of Education, 2014
  • Chan Woon Cheung Memorial Fund Award, Hong Kong Society of Nephrology, 2010 


Professional Service

  • Vice President, Chinese Society of Renal Physiology
  • Editor, Clinical Experimental Pharmacology and Physiology
  • Associate Editor, Frontier in Physiology
  • Associate Editor, Journal of Cellular and Molecular Medicine
  • Editorial Board members, Journal of the American Society of Nephrology
  • Editorial Board members, Molecular Therapy
  • Editorial Board members, International Journal of Biological Sciences
  • Editorial Board members, Scientific Reports
  • Editorial Board members, Kidney Diseases


Academic Engagement in CUHK

  • Chairman, Animal Experimentation Ethics Committee
  • Chairman, International Student Exchange Committee, Lee Woo Sing College
Selected Publications



  1. Tang PM, Zhou S, Li CJ, Liao J, Xiao J, Wang QM, Lian GY, Li J, Huang XR, To KF, Ng CF, Chong CC, Ma RC, Lee TL, Lan HY. The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring. Kidney Int.93(1):173-187, 2018.
  2. Sun SF, Tang PMK, Feng M, Xiao J, Huang XR, Li P, Ma RCW, Lan HY. Novel lncRNA Erbb4-IR Promotes Diabetic Kidney Injury in db/db Mice by Targeting miR-29b. Diabetes. 67(4):731-744, 2018.
  3. Tang PM, Zhou S, Meng XM, Wang QM, Li CJ, Lian GY, Huang XR, Tang YJ, Guan XY, Yan BP, To KF, Lan HY. Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development. Nat Commun.8:14677, 2017.
  4. Wang YY, Jiang H, Pan J, Huang XR, Wang YC, Huang HF, To KF, Nikolic-Paterson DJ, Lan HY, Chen JH. Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury. J Am Soc Nephrol. 28(7):2053-2067, 2017.
  5. Meng XM, Huang XR, Xiao J, Chung AC, Qin W, Lan HY. Disrupted Smad4 impairs TGF-/Smad3 and Smad7 transcriptional regulation in renal inflammation and fibrosis in vivo and in vitro. Kidney Int 81:266-79, 2012.
  6. Zhong X, Chung AC, Chen HY, Meng XM, Lan HY. Smad3-Mediated Upregulation of miR-21 Promotes Renal Fibrosis. J Am Soc Nephrol. 22:1668-81, 2011.
  7. Qin W, Chung AC, Huang XR, Meng XM, Hui DS, Yu CM, Sung JJ, Lan HY. TGF-{beta}/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29. J Am Soc Nephrol. 22:1462-1474, 2011.
  8. Chen H, Huang XR, Wang W, Li J, Heuchel RL, Chung AC, Lan HY. The Protective Role of Smad7 in Diabetic Kidney Disease: Mechanism and Therapeutic Potential. Diabetes. 60:590-601, 2011.
  9. Meng X, Huang XR, Chung ACK, Shao X, Igarashi P, Ju W, Berttinger E, Lan HY: Smad2 protects against TGF-/Smad3-mediated extracellular matrix production and renal fibrosis in vitro and in vivo. J Am Soc Nephrol 21:1477-87, 2010.
  10. Chung AC, Huang XR, Meng X, Lan HY. miR-192 Mediates TGF-{beta}/Smad3-Driven Renal Fibrosis. J Am Soc Nephrol. 21: 1317-1325,2010.
  11. Koka V, Wang W , Huang XR , Kim-Mitsuyama S, Truong LD, Lan HY: Advanced Glycation End Products Activate a Chymase-Dependent Angiotensin II Generating Pathway in Diabetic Complications. Circulation 113(10):1353-60, 2006.
  12. Wang W, Huang XR, Canlas E, Oka K, Truong LD, Deng C, Bhowmick NA, Ju W, Bottinger EP, Lan HY: Essential role of Smad3 in Angiotensin II-Induced Vascular Sclerosis. Circ. Res. 98:1032-9, 2006.