Professor CHIU Wai Kwun, Rossa

Development - Associate Dean

Choh-Ming Li Professor of Chemical Pathology, Department of Chemical Pathology

Development - Associate Dean

Professor CHIU Wai Kwun, Rossa

Department of Chemical Pathology

Contact Information
Office : (852) 3505-2563
Email :

School / Department / Institute / Centre / Unit
Chemical Pathology / Li Ka Shing Institute of Health Sciences

Chemical Pathology, Molecular Diagnostics, Molecular Pathology, Genetics, Genomics

1997 Bachelor of Medicine and Bachelor of Surgery (University of Queensland)
2004 Doctor of Philosophy (CUHK)
2004 Fellow of the Royal College of Pathologists of Australasia
2005 Fellow of the Hong Kong College of Pathologists
2005 Fellow of the Hong Kong Academy of Medicine (Pathology)
2013 Fellow of the Royal College of Pathologists of Australasia (Genetic Pathology)

Research Interests
Development of non-invasive prenatal diagnostic approaches
Development of non-invasive cancer diagnostic approaches
Clinical applications of circulating nucleic acid analysis
Understanding of the biology of circulating nucleic acids
Development of novel molecular diagnostic strategies and innovative applications of molecular analysis tools

Additional Information
Secretary to the Board of Directors, International Society of Prenatal Diagnosis
Board of Directors, International Society of Prenatal Diagnosis
Associate Editor Clinical Chemistry
Editorial Board member of Prenatal Diagnosis
Editorial Board member Clinical Biochemistry
Editorial Board member of Clinical Chemistry and Laboratory Medicine
Selected Publications

  1. Hudecova I, Jiang P, Davies J, Lo YMD, Kadir RA, Chiu RWK (2017).Noninvasive detection of F8 int22h-related inversions and sequence variants in maternal plasma of hemophilia carriers. Blood 130:340-7.
  2. Hui WW, Jiang P, Tong YK, Lee WS, Cheng YK, New MI, Kadir RA, Chan KCA, Leung TY, Lo YMD and Chiu RWK (2017). Universal haplotype-based noninvasive prenatal testing for single gene diseases. Clin Chem 63: 513-24.
  3. Benn P, Borrell A, Chiu RWK, Cuckle H, Dugoff L, Faas B, Gross S, Huang T, Johnson J, Maymon R, Norton M, Odibo A, Schielen P, Spencer K, Wright D and Yaron Y (2015). Position statement from the Chromosome Abnormality Screening Committee on behalf of the Board of the International Society for Prenatal Diagnosis. Prenat Diagn 35: 725-34.
  4. Yu SCYJ, Chan KCA, Zheng YW, Jiang P, Liao GJW, Sun H, Akolekar R, Leung TY, Go AT, van Vugt JM, Minekawa R, Oudejans CBM, Nicolaides KH, Chiu RWK, Lo YMD (2014). Size-based molecular diagnostics using plasma DNA for noninvasive prenatal testing. Proc Natl Acad Sci U S A 111, 8583-8.
  5. *Lun FMF, *Chiu RWK, Sun K, Leung TY, Jiang P, Chan KCA, Sun H and Lo YMD (2013). Noninvasive prenatal methylomic analysis by genomewide bisulfite sequencing of maternal plasma DNA. Clin Chem. 59, 1583-94  (*Equal first authors).
  6. Yu SCYJ, Jiang P, Choy KW, Chan KCA, Won HS, Leung WC, Lau ET, Tang MH, Leung TY, Lo YMD and Chiu RWK (2013). Noninvasive prenatal molecular karyotyping from maternal plasma. PLoS One 8, e60968
  7. Chiu RWK, Akolekar R, Zheng YW, Leung TY, Sun H, Chan KCA, Lun FMF, Go AT, Lau ET, To WW, Leung WC, Tang RY, Au-Yeung SK, Lam H, Kung YY, Zhang X, van Vugt JM, Minekawa R, Tang MH, Wang J, Oudejans CB, Lau TK, Nicolaides KH, Lo YMD (2011). Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study. BMJ 342, c7401.
  8. Lo YMD, Chan KCA, Sun H, Chen EZ, Jiang P, Lun FMF, Zheng YW, Leung TY, Lau TK, Cantor CR, Chiu RWK (2010). Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus. Sci Transl Med 2, 61ra91.
  9. Chiu RWK, Chan KCA, Gao Y, Lau VYM, Zheng W, Leung TY, Foo CH, Xie B, Tsui NBY, Lun FMF, Zee BC, Lau TK, Cantor CR, Lo YMD (2008). Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma. Proc Natl Acad Sci U S A 105, 20458-63.
  10. Chiu RWK, Lau TK, Leung TN, Chow KCK, Chui DHK and Lo YMD (2002). Prenatal exclusion of beta thalassaemia major by examination of maternal plasma. Lancet 360, 998-1000.
Undergraduate MBChB
Global Physician Leadership Stream MBChB
Postgraduate Division of Chemical Pathology
Member of the Central Coordinating Committee of the Office of Medical Education