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  • 生物醫學學院院長及教授
  • 大腦與認知研究所副所長
  • 敬文書院院務委員

  • 腫瘤生物學


BSc in Biochemistry (Lancaster University), Ph.D. in Molecular Biology (University of London)

  • 癌細胞信息傳導
  • 自閉症和阿爾茨海默氏病的遺傳學
  • 小鼠疾病模型





  • 美國國家衛生研究院 Fogarty International Fellow, 1989-1992
  • 美國西奈山醫學院 Irma T. Hirschl Career Scientist Award, 1996-2001
  • 中國西南醫科大學訪問教授



  • 美國國防部預算評審部成員
  • 美國國家衛生研究院PO1, SRRB, SBIT/STTR, RC2, TPM研究基金評審
  • 香港食物及衞生局醫療衞生研究基金評審委員會成員
  • Recent Patents on Anti-Cancer Drug Discovery 地區編輯
  • Cancer Letters 編輯委員會成員



  • 腫瘤生物學及實驗藥物治療學主任
  • 敬文書院 External Links and Exchange 委員會主席
  • 香港生物科技研究院管理局成員
  • 生物醫學理學士課程委員會成員
部分論文 (只有英文版本)


  1. Wong CW, Or PMY, Wang Y, Li L, Li J, Yan M, Cao Y, Luk HM, Tong TMF, Leslie NR, Lo IFM, Choy RKW, Chan AM. Identification of a PTEN mutation with reduced protein stability, phosphatase activity, and nuclear localization in Hong Kong patients with autistic features, neurodevelopmental delays and macrocephaly. Autism Research, 11, 1098-1109. 2018.
  2. Yan M, Wang Y, Wong CW, Or PM, Wong KL, Li L, Many AM, Guan H, Khoo US, Chan AM. PTEN PDZ-binding domain suppresses mammary carcinogenesis in the MMTV-PyMT breast cancer model. Cancer Lett, 430, 67-78. 2018.
  3. Knafo S, Sanchez-Puelles C, Palomer E, Delgado I, Draffin JE, Mingo J, Wahle T, Kaleka K, Mou L, Pereda-Perez I, Klosi E, Faber EB, Chapman HM, Lozano-Montes L, Ortega-Molina A, Ordonez-Guiterrez L, Wandosell F, Vina J, Dotti CG, Hall RA, Pulido R, Gerges NZ, Chan AM, Spaller MR, Serrano M, Venero C, Esteban JA. PTEN recruitment controls synaptic and cognitive function in Alzheimer’s models. Nature Neuroscience, 19, 443-45 2016.
  4. Singh, G., Hashimoto, D., Yan, X., Helft, J., Ma, G., Qiao, R.F., Kennedy, C.R., Chen, S.-H., Merad, M., & Chan, A.M. (2012). R-Ras is required for Murine Dendritic cell maturation and CD4+ T-cell priming. Blood, 119, 1693-1701.
  5. Odriozola, L., Singh, G., Hoang, T., & Chan, A.M. (2007). Regulation of PTEN Activity by its Carboxyl-terminal Autoinhibitory domain. J Biol Chem, 282, 23306-2331
  6. Goutham N., Heath, K.E., Reeves, H.L., Li, D., Giono, L.E., Kimmelman, A.C., Glucksman, M.J., Narla, J., Eng, F.J., Chan, A.M., Ferrari, A.C., Martignetti, J.A., & Friedman, S.L. (2001). KLF6, a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer. Science, 294, 2563-256
  7. Tolkacehva, T., Boddapati, M., Sanfiz, A., Tsuchida, K., Kimmelman, A.C., & Chan, A.M. (2001). Regulation of PTEN binding to MAGI-2 by two putative phosphorylation sites at Threonine codon 382 & 383. Cancer Research, 61, 4985-4989.
  8. Clark, J., Rocques, P.J., Crew, A.J., Gill, S., Shipley, J., Chan, A.M., Gusterson, B.A., & Cooper, C.S. (1994). Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. Nature Genetics, 7, 502-50
  9. Chan, A.M., Miki, T., Meyers, K.A., & Aaronson, S.A. (1994). A new human oncogene of the ras superfamily unmasked by expression cDNA cloning. Proc Natl Acad Sci USA, 91, 7558-7562.
  10. Bottaro, D.P., Rubin, J.S., Falletto, D.L., Chan, A.M., Kmiecik, T.E., Vande Woude, G.F., & Aaronson, S.A. (1991). Identification of the HGF receptor as the c-met protooncogene product. Science, 251, 802-804.