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Dr. KO Ho, Owen

Dr. KO Ho, Owen

Assistant Dean (Research)

Assistant Professor, Department of Medicine and Therapeutics

CUHK Employment
  • Assistant Dean (Research), Faculty of Medicine

  • Assistant Professor, Department of Medicine and Therapeutics, School of Biomedical Science

  • Assistant Professor (by courtesy), Department of Psychiatry

  • Associate Director, Margaret K. L Cheung Research Centre for Management of Parkinsonism

  • Principal Investigator, Li Ka Shing Institute of Health Sciences

  • Principal Investigator, Gerald Choa Neuroscience Centre


  • Neuroscience


Education & Qualifications




Research Interests
  • Glial and vascular cell dysfunction in neurodegenerative disorders
  • Neural circuits
  • Development of imaging tools 


Additional Information

Award and Honour

  • Croucher Innovation Award, The Croucher Foundation, 2020
  • Finalist, Eppendorf and Science Prize for Neurobiology, 2014
Selected Publications

Researcher ID:


  1. Zhao L, Li Z, Vong JSL, Chen X, Lai HM, Yan LYC, Huang J, Sy SKH, Tian X, Huang Y, Chan HYE, So HC, Ng WL, Tang Y, Lin WJ, Mok VCT, Ko H. Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain. Nature Communications. 2020 Sep 4;11(1):4413.
  2. Ko H, Lam BYK, Mok VCT. Pathophysiology of vascular cognitive impairment (II): amyloid contribution in vascular cognitive impairment. Invited book chapter in Stroke Revisited: Vascular Cognitive Impairment. Springer Press. 2020 ISBN 978-981-10-1433-8.
  3. Li Q, Ko H (co-1st author), Qian ZM, Yan LYC, Chan DCW, Arbuthnott GW, Ke Y, Yung WH. Refinement of learned skilled movement representation in motor cortex deep output layer. Nature Communications. 2017 Jun 9;8:15834.
  4. Okun M, Steinmetz N, Cossell L, Iacaruso MF, Ko H, Bartho P, Moore T, Hofer SB, Mrsic-Flogel TD, Carandini M, Harris KD. Diverse coupling of neurons to populations in sensory cortex. Nature. 2015 May 28;521(7553):511-5.
  5. Cossell L, Iacaruso MF, Muir DR, Houlton R, Sader EN, Ko H, Hofer SB, Mrsic-Flogel TD. Functional organization of excitatory synaptic strength in primary visual cortex. Nature. 2015 Feb 19;518(7539):399-403.
  6. Ko H. Functional organization of synaptic connectivity in the neocortex. Runner-up, Eppendorf and Science Prize for Neurobiology 2014. Science. 2014 Oct 31; 346(6209):555.
  7. Ko H, Mrsic-Flogel TD, Hofer SB. Emergence of feature-specific connectivity in cortical microcircuits in the absence of visual experience. The Journal of Neuroscience. 2014 Jul 16;34(29):9812-6.
  8. Ko H, Cossell L, Baragli C, Antolik J, Clopath C, Hofer SB, Mrsic-Flogel TD. The emergence of functional microcircuits in visual cortex. Nature. 2013 Apr 4;496(7443):96-100.
  9. Hofer SB, Ko H(co-1st author), Pichler B, Vogelstein J, Ros H, Zeng H, Lein E, Lesica NA, Mrsic-Flogel TD. Differential connectivity and response dynamics of excitatory and inhibitory neurons in visual cortex. Nature Neuroscience. 2011 Jul 17;14(8):1045-52.
  10. Ko H, Hofer SB, Pichler B, Buchanan KA, Sjostrom PJ, Mrsic-Flogel TD. Functional specificity of local synaptic connections in neocortical networks. Nature. 2011 May 5;473(7345):87-91.