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Dr. KO Ho, Owen

Dr. KO Ho, Owen

Assistant Dean (Research)

Associate Professor, Department of Medicine and Therapeutics

CUHK Employment
  • Assistant Dean (Research), Faculty of Medicine

  • Associate Professor, Department of Medicine and Therapeutics

  • Associate Director, Margaret K.L. Cheung Research Centre for Management of Parkinsonism

  • Associate Director, Lau Tat-chuen Research Centre of Brain Degenerative Diseases in Chinese

  • Principal Investigator, Li Ka Shing Institute of Health Sciences

  • Principal Investigator, Gerald Choa Neuroscience Institute


  • Neuroscience


Education & Qualifications




Research Interests
  • Gliovascular dysfunction and therapeutic targeting in neurodegenerative disorders
  • Neural circuits mediating sensorimotor behaviors and their dysfunction in aging
  • Development of imaging tools and methods


Additional Information

Award and Honour

  • Fellow (Life Science), Asian Young Scientist Fellowship, 2023
  • Sir David Todd Lectureship, Hong Kong College of Physicians, 2022
  • Awardee, Excellent Young Scientists Fund (Hong Kong and Macau), National Natural Science Foundation of China, 2021
  • Croucher Innovation Award, Croucher Foundation, 2020
  • Finalist, Eppendorf and Science Prize for Neurobiology, 2014
Selected Publications

Researcher ID:


  1. Principles of deep immunostaining techniques for 3D histology.
    Yau CN, Lai HM, Lee K, Kwok AJ, Huang J, Ko H.
    Cell Reports Methods. 2023 May 22;3:100458.
  2. An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish.
    Sy SKH, Chan DCW, Chan RCH, Lyu J, Li Z, Wong KKY, Choi CHJ, Mok VCT, Lai HM, Randlett O, Hu Y, Ko H.

    Nature Communications. 2023 Jan 14;14(1):227.
  3. Antibody stabilization for thermally accelerated deep immunostaining.
    Lai HM, Tang Y, Lau ZYH, Campbell RAA, Yau CN, Chan CCY, Chan DCW, Wong HKT, Yan LYC, Wu WKK, Wong SH, Kwok KW, Wing YK, Lam HHN, Ng HK, Mrsic-Flogel TD, Mok VCT, Chan JYK, Ko H.
    Nature Methods. 2022 Sep 1; 19(9):1137-1146.
  4. Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner.
    Li Z, Chen X, Vong JSL, Zhao L, Huang J, Yan LYC, Ip B, Wing YK, Lai HM, Mok VCT, Ko H.
    Communications Biology. 2021 Jun 2;4(1)656.
  5. Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain.
    Zhao L, Li Z, Vong JSL, Chen X, Lai HM, Yan LYC, Huang J, Sy SKH, Tian X, Huang Y, Chan HYE, So HC, Ng WL, Tang Y, Lin WJ, Mok VCT, Ko H.
    Nature Communications. 2020 Sep 4;11(1):4413.
  6. Refinement of learned skilled movement representation in motor cortex deep output layer.
    Li Q*Ko H*, Qian ZM, Yan LYC, Chan DCW, Arbuthnott GW, Ke Y, Yung WH.
    Nature Communications. 2017 Jun 9; 8:15834.
  7. Emergence of feature-specific connectivity in cortical microcircuits in the absence of visual experience.
    Ko H, Mrsic-Flogel TD, Hofer SB.
    Journal of Neuroscience. 2014 Jul 16:34(29):9812-9816.
  8. The emergence of functional microcircuits in visual cortex.
    Ko H, Cossell L, Baragli C, Antolik J, Clopath C, Hofer SB, Mrsic-Flogel TD.
    Nature. 2013 Apr 4;496(7443):96-100.
  9. Differential connectivity and response dynamics of excitatory and inhibitory neurons in visual cortex.
    Hofer SB*Ko H*, Pichler B, Vogelstein J, Ros H, Zeng H, Lein E, Lesica NA, Mrsic-Flogel TD.
    Nature Neuroscience. 2011 Jul 17;14(8):1045-52.
  10. Functional specificity of local synaptic connections in neocortical networks. 
    Ko H, Hofer SB, Pichler B, Buchanan KA, Sjöström PJ, Mrsic-Flogel TD.
    Nature. 2011 May 5;473(7345):87-91.