CUHK Researches Proves the Effectiveness of Low-Dose Tricyclic Antidepressant (TCA) in Treating Patients with Refractory Functional Dyspepsia
From left: Ms. LEE, functional dyspepsia patient; Ms. Yawen CHAN, Clinical Psychologist, Hong Kong Institute of Integrative Medicine; Professor Justin WU and Research Associate Ms. Pui Kuan CHEONG from the Division of Gastroenterology and Hepatology, Department of Medicine and Therapeutics, CUHK Medicine.
A recent study conducted by our researchers proved that low-dose imipramine, a tricyclic antidepressant, is an effective treatment option for patients suffering from refractory functional dyspepsia.
While dyspepsia can be caused by Helicobacter Pylori infection and other organic gastric diseases, it is also associated with anxiety and depression. Patients with no identifiable causes are classified as having “functional dyspepsia” as they appear to have continuous or repeated attacks of early satiety, fullness, or epigastric pain or burning. After receiving imipramine, 64% of the subjects were satisfied with the outcome.
Findings were published in the international medical journal The Lancet Gastroenterology & Hepatology.