Accurate risk scores to identify HCC
Hepatocellular Carcinoma (HCC) is a major complication and cause of mortality in chronic hepatitis B patients. PAGE-B and modified PAGE-B (mPAGE-B) scores are risk scores based on objective demographic and laboratory parameters to predict the risk of HCC among patients on antiviral therapy. The study “Reassessing the accuracy of PAGE-B-related scores to predict hepatocellular carcinoma development in patients with chronic hepatitis B” included and analyzed a large sample size of 32,150 patients with chronic hepatitis B. Results proved that PAGE-B and mPAGE-B scores performed accurately in identifying patients with low HCC risk on antiviral therapy, which would lead to a more cost-effective HCC surveillance strategy. (J Hepatol. 2019 Dec 16. pii: S0168-8278(19)30717-2. doi: 10.1016/j.jhep.2019.12.005. [Epub ahead of print])
Anyone interested in future collaboration in this field of research is welcome to contact our key investigator Prof. Henry CHAN in the Department of Medicine and Therapeutics, CUHK. Prof. Chan’s research focuses on viral hepatitis, liver fibrosis, liver cancer, anti-viral therapy and fatty liver disease.