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Epigenomics study for new intervention strategies of hepatocellular carcinoma


Genetic and epigenetic alterations in the chronic inflammatory milieu lead to the initiation and progression of hepatocellular carcinoma, the most common type of primary liver cancer; but the precise molecular events are still unclear. The epigenomics study “Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming” uses hepatocellular carcinoma methylome profiling to uncover epigenetic vulnerabilities for the development of new intervention strategies (Nat Commun. 2019 Jan 18;10(1):335. doi: 10.1038/s41467-018-08245-z).
Anyone interested in future collaboration in this field of research is welcome to contact our key investigator, Prof Ka Fai To, chairman of our Department of Anatomical and Cellular Pathology. Prof To's research interests include common Asian Cancer, gastrointestinal pathology and molecular diagnostic. He has published over 300 articles in international peer review journals
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