Therapeutic potential of lipogenesis inhibitors
Findings on the “Activation of sterol regulatory element‐binding protein 1 (SREBP1)‐mediated lipogenesis by the Epstein–Barr virus‐encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma” reveal the therapeutic potential of utilizing lipogenesis inhibitors in the treatment of locally advanced or metastatic nasopharyngeal carcinoma. Luteolin, a dietary flavonoid with low toxicity, seems especially promising for the inhibition of Epstein–Barr virus infection and the treatment of Epstein–Barr virus associated cancers; thus warranting further evaluation, particularly in clinical trials.
Anyone interested in future collaboration in this field of research is welcome to contact our key investigator, Prof Kwok-Wai Lo of our Department of Anatomical and Cellular Pathology. Prof Lo’s research interest is in the molecular basis of nasopharyngeal carcinoma and his research group has focused on the identification and functional characterization of NPC-associated tumor suppressor genes and oncogenes.
Read the full article: https://onlinelibrary.wiley.com/doi/full/10.1002/path.5130
More about research at CU Medicine: https://research.med.cuhk.edu.hk