Search
What are you looking for?
Start main content

Press Releases

Press Releases

https://www.med.cuhk.edu.hk/press-releases/cuhk-develops-a-computational-platform-to-predict-vaccine-effectiveness-by-virus-genome
https://www.med.cuhk.edu.hk/press-releases/cuhk-develops-a-computational-platform-to-predict-vaccine-effectiveness-by-virus-genome

CUHK Develops a Computational Platform to Predict Vaccine Effectiveness by Virus Genome

Largely determined by the level of genetic mismatch between vaccine components and circulating viruses, the effectiveness of the influenza vaccines varies from year to year. A research team led by Professor Maggie Haitian WANG and Professor Benny Chung Ying ZEE, both from The Jockey Club School of Public Health and Primary Care at the Faculty of Medicine of The Chinese University of Hong Kong (CU Medicine), has developed in silico bioinformatics algorithms to predict vaccine effectiveness (VE) before mass vaccination. The latest finding from the team showed that the genetic mismatch could explain more than 80% of the VE variations, and therefore could be used for VE prediction.

 

The innovative algorithms enable in silico real-time prediction for VE using virus genome, in order to inform the government as early as possible in the flu season for evaluating the vaccination scheme as well as for the allocation of medical resources. Details have been published in the journal Vaccine.

 

Prof Benny Zee (left) and Prof Maggie Wang

A research team led by Professor Maggie WANG (right) and Professor Benny ZEE, both from The Jockey Club School of Public Health and Primary Care at CU Medicine, has developed the in silico bioinformatics algorithms to predict vaccine effectiveness before mass vaccination.

 

Timely assessment of VE provides valuable information for influenza vaccination and medical resources allocation strategy

 

Traditionally, VE is evaluated after vaccine uptake through survey studies. Timely assessment of VE is difficult before physical vaccination, thus limiting its applications in policy-making.

 

Based on their patent technology in 2018, researchers from The Jockey Club School of Public Health and Primary Care recently developed an algorithm that can identify and quantify the relationship between VE and genetic mismatch of circulating viruses and vaccine strains. They found that a certain degree of VE deviations can be explained by genetic mismatch. By integrating the information of multiple genes in the virus genome, the method can provide a more accurate VE estimation.

 

Professor Benny Zee

Professor Benny Zee points out that their algorithms can provide a real-time prediction of vaccine effectiveness which may offer practical information for policy-makers to select the optimal product for the local population.

The algorithms innovatively used genetic data to monitor and evaluate the efficacy of influenza vaccines in real time. The results can be a reference for decision makers for better preparation and response during flu season. If there is significant genetic mismatch between the vaccine strains and circulating virus strains, the government can properly allocate manpower and other resources in public hospitals.  

 

Professor Benny Chung Ying ZEE, Director of the Centre for Clinical Research and Biostatistics, The Jockey Club School of Public Health and Primary Care at CU Medicine, stated, “Modeling a relationship between genetic mismatch and VE is of huge significance to public health as it could provide a nowcast of VE before vaccine uptake during epidemics. Regions with year-round influenza activities, such as tropical or subtropical regions, may face uncertainty in choosing vaccine products containing vaccine strains from Northern or Southern Hemisphere. Real-time VE prediction may offer practical information for policy-makers to select the optimal product for the local population.”

 

Professor Maggie Wang

Professor Maggie Wang believes that by providing timely updates on the expected effectiveness of vaccine products on a local population, manufacturers will be able to have a more accurate prediction and selection of virus components for vaccine updates.

Professor Maggie Haitian WANG, Associate Professor from The Jockey Club School of Public Health and Primary Care at CU Medicine, remarked, “We believe the algorithms can provide timely updates on the expected effectiveness of vaccine products on a local population, and enable manufacturers to have a more accurate prediction and selection of virus components for vaccine updates.”

 

In addition, the team has set up a clinic-end web interface for providing real-time evaluation of the vaccines information for clinicians.   

 

The full text of the research paper can be found at:

In silico prediction of influenza vaccine effectiveness by sequence analysis

https://www.sciencedirect.com/science/article/pii/S0264410X21000062

 

Related research:

Differential Influence of Age on the Relationship between Genetic Mismatch and A (H1N1) pdm09 Vaccine Effectiveness 

https://www.mdpi.com/1999-4915/13/4/619

 

 

More Press Releases

CU Medicine Survey Shows Only 25% of Unvaccinated People Intend to Get Inoculated in the Coming Six Months “Multiple Incentives” are Urgently Needed

CU Medicine Survey Shows Only 25% of Unvaccinated People Intend to Get Inoculated in the Coming Six Months “Multiple Incentives” are Urgently Needed

Research
CUHK Develops Automatic Retinal Image Analysis Technology for Identifying Autism Making Objective Screening and Early Intervention Possible

CUHK Develops Automatic Retinal Image Analysis Technology for Identifying Autism Making Objective Screening and Early Intervention Possible

Research
CUHK-Designed Intervention Package Proves Effective to Increase Influenza Vaccine Uptake in Hong Kong Young Children

CUHK-Designed Intervention Package Proves Effective to Increase Influenza Vaccine Uptake in Hong Kong Young Children

Research
CUHK Reveals the Key to a Successful HPV Vaccination Programme

CUHK Reveals the Key to a Successful HPV Vaccination Programme

Research
CUHK Research Reveals New Influenza Vaccine Offers More Effective Control over Influenza in Hong Kong

CUHK Research Reveals New Influenza Vaccine Offers More Effective Control over Influenza in Hong Kong

Research
CUHK Develops an Automatic Retinal Image Analysis System to Help Diabetes Patients and Elderly Prevent Stroke

CUHK Develops an Automatic Retinal Image Analysis System to Help Diabetes Patients and Elderly Prevent Stroke

Research
CU Medicine Estimates 20,000 COVID-19 Hidden Infections in Hong Kong  All Vaccinated Persons in HK Developed Neutralising Antibody After Two Doses  Urgent Call for the Largely Unprotected Population to Get Vaccinated

CU Medicine Estimates 20,000 COVID-19 Hidden Infections in Hong Kong All Vaccinated Persons in HK Developed Neutralising Antibody After Two Doses Urgent Call for the Largely Unprotected Population to Get Vaccinated

Research
CUHK Study Shows Regular Exercise Is a Safe Diabetes Prevention Strategy For People Living in Polluted Regions

CUHK Study Shows Regular Exercise Is a Safe Diabetes Prevention Strategy For People Living in Polluted Regions

Research
CU Medicine Survey Shows Government Recommendation as the Strongest Driver for COVID-19 Vaccine Acceptance

CU Medicine Survey Shows Government Recommendation as the Strongest Driver for COVID-19 Vaccine Acceptance

Research
CUHK Study Shows Exposure Settings Impact COVID-19 Transmission With Entertainment Setting Showing Propensity for Widespread Dispersion

CUHK Study Shows Exposure Settings Impact COVID-19 Transmission With Entertainment Setting Showing Propensity for Widespread Dispersion

Research
CU Medicine Studies Highlight Smoking as a Contributing Factor for Bladder Cancer and  Develop an International Collaborative Consensus on En Bloc Resection to Treat the Disease

CU Medicine Studies Highlight Smoking as a Contributing Factor for Bladder Cancer and Develop an International Collaborative Consensus on En Bloc Resection to Treat the Disease

Research
CU Medicine Finds An Increasing Global Trend on Pancreatic Cancer among Female and Younger Individuals

CU Medicine Finds An Increasing Global Trend on Pancreatic Cancer among Female and Younger Individuals

Research
CUHK Established the Institute of Health Equity Investigates Housing Affordability Effects on Physical and Mental Health

CUHK Established the Institute of Health Equity Investigates Housing Affordability Effects on Physical and Mental Health

Research
CU Medicine Recruits 3,000 Persons to Investigate Hidden Infection and Break the Obstacles in Containing COVID-19 in Hong Kong

CU Medicine Recruits 3,000 Persons to Investigate Hidden Infection and Break the Obstacles in Containing COVID-19 in Hong Kong

Research
CU Medicine Announces the Community Response Study Results During the Early Phase of the COVID-19 Outbreak in Hong Kong

CU Medicine Announces the Community Response Study Results During the Early Phase of the COVID-19 Outbreak in Hong Kong

Research
CUHK-Jockey Club Pain Relief Project for the Seniors Preliminary Data Shows 90% of Interviewed Elderly Have at Least Two Pain Sites

CUHK-Jockey Club Pain Relief Project for the Seniors Preliminary Data Shows 90% of Interviewed Elderly Have at Least Two Pain Sites

Health Campaign
CUHK Promotes The “May Measurement Month” in Response to World Hypertension Day, Calling for Public Awareness on Blood Pressure

CUHK Promotes The “May Measurement Month” in Response to World Hypertension Day, Calling for Public Awareness on Blood Pressure

Health Campaign
Hong Kong’s waters benefit health and wellbeing

Hong Kong’s waters benefit health and wellbeing

Research
CUHK Thomas Jing Centre for Mindfulness Research and Training Established

CUHK Thomas Jing Centre for Mindfulness Research and Training Established

Research
CUHK Study Shows Behavioural Activation with Mindfulness Lower Major Depression Risk

CUHK Study Shows Behavioural Activation with Mindfulness Lower Major Depression Risk

Research
Professor YEOH Eng Kiong Delivers a Talk on End-of-life Care in CUHK Medicine’s Mok Hing Yiu Lecture

Professor YEOH Eng Kiong Delivers a Talk on End-of-life Care in CUHK Medicine’s Mok Hing Yiu Lecture

Symposium
CUHK Proves Rotavirus Vaccine Highly Effective for HK Children

CUHK Proves Rotavirus Vaccine Highly Effective for HK Children

Research
CUHK Asia’s First Comprehensive Epidemiological Study on Health Impact of Household Cleaning Products on Children Reveals Frequent Use of Household Cleaning Products Increase Risk of Triggering Rhinitis in Children

CUHK Asia’s First Comprehensive Epidemiological Study on Health Impact of Household Cleaning Products on Children Reveals Frequent Use of Household Cleaning Products Increase Risk of Triggering Rhinitis in Children

Research
CUHK Research Shows 1 in 5 Throat Cancer Patients in HK is HPV infected

CUHK Research Shows 1 in 5 Throat Cancer Patients in HK is HPV infected

Research
CUHK Conducts Hong Kong’s First Study on Seven Common Respiratory Viruses Revealing Respiratory Syncytial Virus and Influenza A as Prevalent Fatal Types

CUHK Conducts Hong Kong’s First Study on Seven Common Respiratory Viruses Revealing Respiratory Syncytial Virus and Influenza A as Prevalent Fatal Types

Research
CUHK CGH Distinguished Lecture Series: Vision and Experience Sharing from Public Health England

CUHK CGH Distinguished Lecture Series: Vision and Experience Sharing from Public Health England

Symposium
CUHK CGH Distinguished Lecture Series: South Africa Minister of Health Spoke on Impact of Ebola Epidemic in South Africa and African Continent

CUHK CGH Distinguished Lecture Series: South Africa Minister of Health Spoke on Impact of Ebola Epidemic in South Africa and African Continent

Surgical advancement
CUHK Conducts Asia's Largest Clinical Study on Life-threatening Infections caused by RSV and Influenza in Hong Kong Adults and Elderly

CUHK Conducts Asia's Largest Clinical Study on Life-threatening Infections caused by RSV and Influenza in Hong Kong Adults and Elderly

Research
CUHK Green Pioneer Series CUHK Recommends Hong Kong's New Air Quality Objectives Should Not Ignore Coarse Particulate Pollutants

CUHK Green Pioneer Series CUHK Recommends Hong Kong's New Air Quality Objectives Should Not Ignore Coarse Particulate Pollutants

Research
CUHK Urges Widespread Helmet Use and Protective Measures Against Cycling-related Traumatic Brain Injury

CUHK Urges Widespread Helmet Use and Protective Measures Against Cycling-related Traumatic Brain Injury

Research
Opening Ceremony of International Conference on Global Health and Public Health Education and Launching of the CUHK Jockey Club Community Primary Care Programme

Opening Ceremony of International Conference on Global Health and Public Health Education and Launching of the CUHK Jockey Club Community Primary Care Programme

Symposium
The Official Launch of E-community Surveillance System for Influenza-like illness (EcSS) by CUHK

The Official Launch of E-community Surveillance System for Influenza-like illness (EcSS) by CUHK

Health Campaign
Inauguration Ceremony of CCOU Centre for Disaster and Medical Humanitarian Response (CCOUC) Held Today

Inauguration Ceremony of CCOU Centre for Disaster and Medical Humanitarian Response (CCOUC) Held Today

Education
CUHK Green Pioneer Series Findings on Increasing Trend of Primary NO2 Exhaust Emission Fraction in Hong Kong

CUHK Green Pioneer Series Findings on Increasing Trend of Primary NO2 Exhaust Emission Fraction in Hong Kong

Research

Our Expert List

Many experts under the Faculty of Medicine are available for media interview.
Please click here for the expert list or contact us.