Search
What are you looking for?
Start main content

Press Releases

Press Releases

https://www.med.cuhk.edu.hk/press-releases/cuhk-research-reveals-that-stroke-triggers-alzheimers-dementia-risk-of-alzheimers-dementia-can-be-reduced-by-enhancing-vascular-health
https://www.med.cuhk.edu.hk/press-releases/cuhk-research-reveals-that-stroke-triggers-alzheimers-dementia-risk-of-alzheimers-dementia-can-be-reduced-by-enhancing-vascular-health

CUHK Research Reveals that Stroke Triggers Alzheimer’s Dementia Risk of Alzheimer’s Dementia Can be Reduced by Enhancing Vascular Health

Recent research conducted by the Department of Medicine and Therapeutics at The Chinese University of Hong Kong (CUHK) reveals that cerebrovascular diseases are closely correlated with Alzheimer’s dementia. Patients with underlying Alzheimer’s dementia pathology have a 90% chance of developing dementia after a stroke. Findings of research suggest that enhancing vascular health can effectively prevent or delay the onset of Alzheimer’s dementia. The findings have been published recently in an international leading scientific publication, journal of Alzheimer’s and Dementia.

 

Alzheimer’s dementia is the most common neurodegenerative disease worldwide. There are over 35 million people worldwide, including 70,000 in Hong Kong suffering from this disease. The latter is expected to triple in the next 30 years due to aging problems.

 

Alzheimer’s dementia is characterized by progressive loss of cognition, such as memory, executive function and language. Pathologically, it is characterized by deposition of amyloid plaques in the brain. International researches show that one in every three senior citizens aged 65 or above has underlying amyloid plaques in the brain. According to the Census and Statistics Department of HKSAR[1], approximately 35,000 senior citizens in Hong Kong may have underlying amyloid plaques who may later develop Alzheimer’s dementia.

 

Traditionally, Alzheimer’s dementia and cerebrovascular disease (e.g. a stroke) are considered as two different diseases. A research team led by Prof. Vincent C.T. Mok,Division of Neurology, Department of Medicine and Therapeutics at CUHK, studied 1,013 Chinese subjects with an average age of 70 years who suffered from mild to moderate strokes between 2009 and 2010. The result showed that among those who were found to harbor amyloid plaques in their brains, 90% developed dementia after a stroke. Professor Mok explained, ‘From the emergence of amyloid plaques in the brain, it takes 10 to 15 years more on average for the patient to develop dementia. However, a very minor stroke, or even a transient ischemic attack, is able to trigger dementia onset in patients with underlying amyloid plaques. In other words, a stroke is a catalyst of the process. Early studies recognized that cerebrovascular disease is present in as many as 50% of Alzheimer’s dementia patients. Therefore, we believe that 50% of dementia can be prevented or delayed if cerebrovascular disease can be prevented, despite the lack of effective treatment towards amyloid plaques.’

 

Dr. Lisa Au, Clinical Tutor (Honorary), Division of Neurology, Department of Medicine and Therapeutics at CUHK, stated, ‘The present study provides strong evidence that cerebrovascular disease triggers Alzheimer’s dementia. Maintaining vascular health will not only lower the risk of cardiovascular and cerebrovascular disease, but also prevent dementia.’ Dr. Au also pointed out that preventive measures of cerebrovascular disease include treatment of hypertension and dyslipidemia, smoking cessation, increase of physical activity, weight reduction in obese individuals, adoption of a healthy diet and the use of anticoagulant drugs in subjects with atrial fibrillation.

 

Looking forward, the research team will further investigate the pathology of Alzheimer’s dementia including estimating the prevalence of amyloid plaques among dementia-free elderly subjects and evaluating whether certain drugs are able to clear up amyloid plaques or to prevent dementia onset among those with amyloid plaques.


[1]The Census and Statistics Department of HKSAR : http://www.censtatd.gov.hk/hkstat/sub/sp150_tc.jsp?tableID=002&ID=0&productType=8

 

Prof. Vincent C.T. Mok (right), Professor, and Dr. Lisa Au, Clinical Tutor

Prof. Vincent C.T. Mok (right), Professor, and Dr. Lisa Au, Clinical Tutor (Honorary), Division of Neurology, Department of Medicine and Therapeutics, CUHK

More Press Releases

Most Deaths from COVID-19 in Hong Kong are of 60 Years Old or Above CUHK Initiated International Effort in Devising Strategies to Protect Older People with Dementia amid COVID-19 Pandemic

Most Deaths from COVID-19 in Hong Kong are of 60 Years Old or Above CUHK Initiated International Effort in Devising Strategies to Protect Older People with Dementia amid COVID-19 Pandemic

Research
CUHK Launches World’s First Study Utilizing Retinal Imaging for Alzheimer’s Disease Screening in Chinese Population

CUHK Launches World’s First Study Utilizing Retinal Imaging for Alzheimer’s Disease Screening in Chinese Population

Research
CUHK Sets up the Global First Research Registry on Early Onset Dementia in Chinese Population

CUHK Sets up the Global First Research Registry on Early Onset Dementia in Chinese Population

Research
CUHK Screening Reveals 1 in 3 Older Adults in Community Suffer Brain Small Vessel Disease, Early Prevention Recommended

CUHK Screening Reveals 1 in 3 Older Adults in Community Suffer Brain Small Vessel Disease, Early Prevention Recommended

Clinical service
CUHK Establishes Margaret K.L. Cheung Research Centre for Management of Parkinsonism  To Develop Innovative Solutions to Slow Disease Progression

CUHK Establishes Margaret K.L. Cheung Research Centre for Management of Parkinsonism To Develop Innovative Solutions to Slow Disease Progression

Research
CUHK Conducts World’s First Family Study on Rapid Eye Movement Sleep Behaviour Disorder to Investigate Familial Link with Parkinson’s Disease

CUHK Conducts World’s First Family Study on Rapid Eye Movement Sleep Behaviour Disorder to Investigate Familial Link with Parkinson’s Disease

Research
CUHK Pioneers in Developing Standardised Tests for Screening Cognitive Impairment in the Ageing Population in Hong Kong

CUHK Pioneers in Developing Standardised Tests for Screening Cognitive Impairment in the Ageing Population in Hong Kong

Clinical service
CUHK Sees Atrial Fibrillation-related Stroke Cases 3 Times Higher Over 15 Years

CUHK Sees Atrial Fibrillation-related Stroke Cases 3 Times Higher Over 15 Years

Research
CUHK’s Gerald Choa Neuroscience Centre Unveils Mystery of How Brain Learns Motor Skills

CUHK’s Gerald Choa Neuroscience Centre Unveils Mystery of How Brain Learns Motor Skills

Research
CUHK Professor Receives World Honour For Stroke Services Pioneering an Innovative 3-in-1 Multi-Target Therapy to Repair Damaged Brain After Stroke and Enhance Functional Recovery

CUHK Professor Receives World Honour For Stroke Services Pioneering an Innovative 3-in-1 Multi-Target Therapy to Repair Damaged Brain After Stroke and Enhance Functional Recovery

Awards and honors
CUHK Opens Therese Pei Fong Chow Research Centre for Prevention of Dementia and Establishes a One-stop Online Platform to Provide Information on Dementia

CUHK Opens Therese Pei Fong Chow Research Centre for Prevention of Dementia and Establishes a One-stop Online Platform to Provide Information on Dementia

Research
CUHK Jointly Discovers New Therapeutic Solution for Minor Stroke in Global Study with over 30 Countries

CUHK Jointly Discovers New Therapeutic Solution for Minor Stroke in Global Study with over 30 Countries

Research
CUHK Sees Early Evaluation of TIA Patients Reduce Rate of Stroke by 70% in a Global Study of 21 Countries

CUHK Sees Early Evaluation of TIA Patients Reduce Rate of Stroke by 70% in a Global Study of 21 Countries

Research
CUHK Advocates Stringent Control of Cardiovascular Risks for Reopening of Narrowed Brain Arteries - A New Paradigm to Prevent Recurrent Stroke (Available in Chinese only)

CUHK Advocates Stringent Control of Cardiovascular Risks for Reopening of Narrowed Brain Arteries - A New Paradigm to Prevent Recurrent Stroke (Available in Chinese only)

Research
Joint Study by CUHK and HKSH Reveals Patients with Comorbid REM Sleep Behavior Disorder and Depression may Suffer from Early-stage Neurodegeneration

Joint Study by CUHK and HKSH Reveals Patients with Comorbid REM Sleep Behavior Disorder and Depression may Suffer from Early-stage Neurodegeneration

Research
CUHK and PolyU Jointly Introduce TeleStroke for 24-hour Thrombolysis Service at Prince of Wales Hospital

CUHK and PolyU Jointly Introduce TeleStroke for 24-hour Thrombolysis Service at Prince of Wales Hospital

Clinical service
CUHK Proves External Counterpulsation Helps Augment Cerebral Blood Flow among Ischemic Stroke Patients

CUHK Proves External Counterpulsation Helps Augment Cerebral Blood Flow among Ischemic Stroke Patients

Research
CUHK Develops an Automatic Retinal Image Analysis System to Help Diabetes Patients and Elderly Prevent Stroke

CUHK Develops an Automatic Retinal Image Analysis System to Help Diabetes Patients and Elderly Prevent Stroke

Research
Good News for Asian Patients First Local Clinical Study Shows High Success Rate and Effectiveness of Stenting for Intracranial Stenosis in Preventing Ischaemic Stroke

Good News for Asian Patients First Local Clinical Study Shows High Success Rate and Effectiveness of Stenting for Intracranial Stenosis in Preventing Ischaemic Stroke

Research
CUHK Launches a Population-based Programme to Evaluate and Track Brain Health Status  of 5,000 Hong Kong Residents for Free

CUHK Launches a Population-based Programme to Evaluate and Track Brain Health Status of 5,000 Hong Kong Residents for Free

Research
CUHK/International Study Implicates a Gene in Alzheimer’s disease

CUHK/International Study Implicates a Gene in Alzheimer’s disease

Research
CUHK Introduces High Frequency Oscillations to Determine Resection Margin Increases the Effectiveness of Complex Epilepsy Surgery by around 30%

CUHK Introduces High Frequency Oscillations to Determine Resection Margin Increases the Effectiveness of Complex Epilepsy Surgery by around 30%

Surgical advancement
CUHK Advocates Atrial Fibrillation Screening and Drug Education to Reduce Risk of Stroke among Elderly

CUHK Advocates Atrial Fibrillation Screening and Drug Education to Reduce Risk of Stroke among Elderly

Clinical service
Hong Kong’s First Scientist Awarded Runner-up for the 2014 Eppendorf and Science Prize for Neurobiology CUHK Medical Student Dedicated to Unraveling Mystery of Neuronal Circuits

Hong Kong’s First Scientist Awarded Runner-up for the 2014 Eppendorf and Science Prize for Neurobiology CUHK Medical Student Dedicated to Unraveling Mystery of Neuronal Circuits

Awards and honors
Radiotherapy to Head and Neck Raises Risk for Stroke CUHK Proved Effectiveness of Carotid Angioplasty and Stenting

Radiotherapy to Head and Neck Raises Risk for Stroke CUHK Proved Effectiveness of Carotid Angioplasty and Stenting

Research
CUHK New Research Reveals Better Efficacy of New Oral Anticoagulant for Stroke Prevention in Asian Patients with Atrial Fibrillation

CUHK New Research Reveals Better Efficacy of New Oral Anticoagulant for Stroke Prevention in Asian Patients with Atrial Fibrillation

Research
Dr. Lui Che Woo Distinguished Professor Public Lecture by Prof. Steven C. Cramer on Brain Repair after Stroke

Dr. Lui Che Woo Distinguished Professor Public Lecture by Prof. Steven C. Cramer on Brain Repair after Stroke

Education
CUHK Announces Latest Medical Treatment for Minor Stroke

CUHK Announces Latest Medical Treatment for Minor Stroke

Research
CUHK Proves the Potent Efficacy of Stenting for Carotid Artery Narrowing and Cardiac Contractility Modulation for Heart Failure

CUHK Proves the Potent Efficacy of Stenting for Carotid Artery Narrowing and Cardiac Contractility Modulation for Heart Failure

Research

Our Expert List

Many experts under the Faculty of Medicine are available for media interview.
Please click here for the expert list or contact us.