Search
What are you looking for?
Start main content

Press Releases

Press Releases

https://www.med.cuhk.edu.hk/press-releases/cuhk-establishes-margaret-k-l-cheung-research-centre-for-management-of-parkinsonism-to-develop-innovative-solutions-to-slow-disease-progression
https://www.med.cuhk.edu.hk/press-releases/cuhk-establishes-margaret-k-l-cheung-research-centre-for-management-of-parkinsonism-to-develop-innovative-solutions-to-slow-disease-progression
CUHK Establishes Margaret K.L. Cheung Research Centre for Management of Parkinsonism  To Develop Innovative Solutions to Slow Disease Progression

CUHK Establishes Margaret K.L. Cheung Research Centre for Management of Parkinsonism To Develop Innovative Solutions to Slow Disease Progression

The Faculty of Medicine at The Chinese University of Hong Kong (CUHK) inaugurated the Margaret K.L. Cheung Research Centre for Management of Parkinsonism (the Centre) today (11 April), World Parkinson’s Day. With a generous donation from Ms. Margaret Kam Ling CHEUNG, the Centre is set up to conduct transdisciplinary research that enables the discovery of therapeutics for preventing or slowing the progression of parkinsonism. 


The Centre will establish registries for early stage Parkinson’s disease (PD) and cerebral small vessel disease (SVD), both the most common diseases causing parkinsonism, in Chinese subjects to develop precise biomarkers and diagnostics as well as to predict and monitor disease progression. The team has also built Hong Kong’s first custom-built in vivo multiphoton microscope which will greatly enhance the future development of novel therapeutics that can delay the progression of SVD.

 

With a generous donation from Ms. Margaret Kam Ling CHEUNG, the Faculty of Medicine at CUHK sets up the Margaret K.L. Cheung Research Centre for Management of Parkinsonism on the World Parkinson’s Day (11 April).

With a generous donation from Ms. Margaret Kam Ling CHEUNG (6th from left), the Faculty of Medicine at CUHK sets up the Margaret K.L. Cheung Research Centre for Management of Parkinsonism on the World Parkinson’s Day (11 April). (2nd  from right) Dr. SHI Lin, Principal Investigator of the Centre;  Dr. ZHANG Jihui, Executive Committee Member of the Centre; Professor WING Yun Kwok, Chairman of the Department of Psychiatry at CUHK Medicine; Professor Vincent MOK, Director of the Centre; Professor Francis CHAN, Dean of CUHK Medicine; Professor CHAN Wai Yee, Pro-Vice-Chancellor/Vice-President of CUHK; Dr. Owen KO, Associate Director of the Centre; and (2nd from left) Dr. Anne CHAN, Executive Committee Member of the Centre.

 

The Faculty of Medicine at CUHK establishes the Margaret K.L. Cheung Research Centre for Management of Parkinsonism to conduct transdisciplinary research that enables the discovery of therapeutics for preventing or slowing the progression of parkinsonism.

The Faculty of Medicine at CUHK establishes the Margaret K.L. Cheung Research Centre for Management of Parkinsonism (the Centre) to conduct transdisciplinary research that enables the discovery of therapeutics for preventing or slowing the progression of parkinsonism. (From left) Dr. ZHANG Jihui, Executive Committee Member of the Centre; Dr. Owen KO, Associate Director of the Centre; Professor Vincent MOK, Director of the Centre; and Dr. Anne CHAN, Executive Committee Member of the Centre.

 
Over 6 million individuals suffer from PD globally, while one third of HK elderly are harbouring SVD 

 

Parkinsonism was first identified more than 200 years ago (1817) by Dr. James Parkinson. It refers to a cluster of symptoms that primarily includes slow movement, together with other conditions such as stiffness, tremor and/or instability. The most common diseases causing parkinsonism include idiopathic PD, which is the second most common neurodegenerative disease, and sporadic cerebral SVD. Currently, it is estimated that 6.1 million individuals suffer from PD globally. In China there are 1.7 million and in Hong Kong 12,000 people with PD. It is projected that the number suffering from PD will at least double in the coming two decades because of an ageing society. As for SVD, the prevalence is even higher. About one third of the elderly in Hong Kong are incubating this disease, contributing to a slow and unsteady gait that is commonly seen in many older people. Stroke and dementia are other common manifestations of SVD.

 

Donor Ms. Margaret Kam Ling CHEUNG, said at the inauguration ceremony of the Centre, “Thousands of individuals and their families are being affected by parkinsonism in Hong Kong and around the world. I hope the Centre can advance research breakthroughs in the management of parkinsonism to benefit the well-being of patients and families suffering from parkinsonism.”

 

Professor CHAN Wai Yee, Pro-Vice-Chancellor/Vice-President of CUHK, remarked, “The establishment of this Centre is very timely given the expected increasing burden of parkinsonism coming with the ageing society. We believe this donation will realise the visionary steps taken by CUHK to generate a profound understanding of advancing parkinsonism management, alleviate the suffering of patients and their families and raise up future high quality researchers in this field.”

With a generous donation from Ms. Margaret Kam Ling CHEUNG (6th from left), the Faculty of Medicine at CUHK sets up the Margaret K.L. Cheung Research Centre for Management of Parkinsonism on the World Parkinson’s Day (11 April).

With a generous donation from Ms. Margaret Kam Ling CHEUNG (6th from left), the Faculty of Medicine at CUHK sets up the Margaret K.L. Cheung Research Centre for Management of Parkinsonism on the World Parkinson’s Day (11 April).

Experts from different disciplines unite in the fight against parkinsonism

 

Despite certain breakthroughs made over the centuries in the management of parkinsonism, there is still no effective treatment that can slow progression of PD and SVD. Professor Vincent Chung Tong MOK, Director of the Centre, Mok Hing Yiu Professor of Medicine and Head of the Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine at CUHK, stated, “Developing novel disease-modifying therapeutics that can be applied at the earliest stage of the disease is the grand challenge in the fight against parkinsonism.”

 

To tackle this challenge, the Centre will unite researchers from different disciplines (including clinician scientists, neurologists, psychiatrists, neuroscientists, radiologists and engineers). The team will focus on unravelling disease mechanisms and developing early detection methods and therapeutics that can slow the progression of the diseases.
 

Professor Vincent MOK states that developing novel disease-modifying therapeutics that can be applied at the earliest stage of the disease is the greatest challenge in the fight against parkinsonism.

Professor Vincent MOK states that developing novel disease-modifying therapeutics that can be applied at the earliest stage of the disease is the greatest challenge in the fight against parkinsonism.

Hong Kong first’s custom-built multiphoton microscope for SVD pathogenesis

 

Basic research focusing on SVD is severely lacking in Hong Kong and Asia. The Centre has built a state-of-the-art in vivo multiphoton microscope dedicated to the study of SVD. Dr. Owen Ho KO, Associate Director of the Centre, Assistant Professor and Head of Translational Neuroscience Unit at the Division of Neurology, Department of Medicine and Therapeutics and Assistant Professor of the School of Biomedical Sciences, Faculty of Medicine at CUHK, explained, “Our system allows simultaneous measurements of neuronal and neurovascular changes in awake behaving animals, for studying pathogenic changes in the structure and functions of brain vasculature in animal models of SVD. Combined with single-cell genomic techniques, our work will enhance the fundamental understanding of the pathogenesis underlying SVD, the knowledge of which is crucial for the future development of novel therapeutics that can delay disease progression.” The Centre has also built cellular and animal laboratories for conducting other basic research for PD and SVD.

 

 

The Faculty has built a Hong Kong’s first in vivo multiphoton microscope dedicated to the study of cerebral small vessel disease which will enhance the fundamental understanding of the underlying pathogenesis, the knowledge of which is crucial for the future development of novel therapeutics that can delay disease progression.

The Faculty has built a Hong Kong’s first in vivo multiphoton microscope dedicated to the study of cerebral small vessel disease which will enhance the fundamental understanding of the underlying pathogenesis, the knowledge of which is crucial for the future development of novel therapeutics that can delay disease progression.

The Faculty has built a Hong Kong’s first in vivo multiphoton microscope dedicated to the study of cerebral small vessel disease which will enhance the fundamental understanding of the underlying pathogenesis, the knowledge of which is crucial for the future development of novel therapeutics that can delay disease progression.

The Faculty built Hong Kong’s first in vivo multiphoton microscope.

 
Setting up an Early PD and SVD registries in Chinese population

 

Dr. Anne Yin Yan CHAN, Executive Committee Member of the Centre and Clinical Associate Professor (Honorary), Head of Parkinson’s Disease and Movement Disorder Unit, Division of Neurology, Department of Medicine and Therapeutics at CUHK, added, “As well as motor problems, PD is commonly associated with non-motor features such as cognitive and behavioural problems as the disease continues to progress, which further aggravate the disability. Current treatments (including dopaminergic drugs and deep brain stimulation) mainly help improve motor symptoms. Moreover, around 50% to 80% of the dopaminergic nerve cells are lost when the motor symptoms appear. Identifying subjects at an earlier stage and intervening early when degeneration is less severe will offer a higher chance of slowing disease progression as well as preventing the development of disabling symptoms.”

 

To this end, the Centre will establish registries for early stage PD and SVD in Chinese subjects. These registries will collect data among subjects who are at the early stage, e.g. subjects with REM Sleep Behavioural Disorder (RBD) which is considered as one of the earliest symptoms of PD. Dr. ZHANG Jihui, Executive Committee Member of the Centre and Assistant Professor, Department of Psychiatry, Faculty of Medicine at CUHK, said, “In this collaboration, we aim to develop precise biomarkers and diagnostics, e.g. clinical, whole genome sequencing, microbiota, and neuroimaging, to understand genetic and other putative causative factors, as well as to predict and monitor disease progression at the early stage of PD in the Chinese.” The Centre will also utilise the state-of-art MRI postprocessing technology (AccubrainTM) developed by Dr. SHI Lin, Principal Investigator of the Centre and Assistant Professor, Department of Imaging and Interventional Radiology, Faculty of Medicine at CUHK, to quantify automatically volumetric changes of multiple brain volumes at the early stage of the disease.

More Press Releases

CUHK Conducts World’s First Family Study on Rapid Eye Movement Sleep Behaviour Disorder to Investigate Familial Link with Parkinson’s Disease

CUHK Conducts World’s First Family Study on Rapid Eye Movement Sleep Behaviour Disorder to Investigate Familial Link with Parkinson’s Disease

Research
CUHK Pioneers in Developing Standardised Tests for Screening Cognitive Impairment in the Ageing Population in Hong Kong

CUHK Pioneers in Developing Standardised Tests for Screening Cognitive Impairment in the Ageing Population in Hong Kong

Clinical service
CUHK Launches World’s First Study Utilizing Retinal Imaging for Alzheimer’s Disease Screening in Chinese Population

CUHK Launches World’s First Study Utilizing Retinal Imaging for Alzheimer’s Disease Screening in Chinese Population

Research
CUHK’s Gerald Choa Neuroscience Centre Unveils Mystery of How Brain Learns Motor Skills

CUHK’s Gerald Choa Neuroscience Centre Unveils Mystery of How Brain Learns Motor Skills

Research
CUHK Opens Therese Pei Fong Chow Research Centre for Prevention of Dementia and Establishes a One-stop Online Platform to Provide Information on Dementia

CUHK Opens Therese Pei Fong Chow Research Centre for Prevention of Dementia and Establishes a One-stop Online Platform to Provide Information on Dementia

Research
CUHK Sets up the Global First Research Registry on Early Onset Dementia in Chinese Population

CUHK Sets up the Global First Research Registry on Early Onset Dementia in Chinese Population

Research
CUHK Screening Reveals 1 in 3 Older Adults in Community Suffer Brain Small Vessel Disease, Early Prevention Recommended

CUHK Screening Reveals 1 in 3 Older Adults in Community Suffer Brain Small Vessel Disease, Early Prevention Recommended

Clinical service
Joint Study by CUHK and HKSH Reveals Patients with Comorbid REM Sleep Behavior Disorder and Depression may Suffer from Early-stage Neurodegeneration

Joint Study by CUHK and HKSH Reveals Patients with Comorbid REM Sleep Behavior Disorder and Depression may Suffer from Early-stage Neurodegeneration

Research
CUHK Launches a Population-based Programme to Evaluate and Track Brain Health Status  of 5,000 Hong Kong Residents for Free

CUHK Launches a Population-based Programme to Evaluate and Track Brain Health Status of 5,000 Hong Kong Residents for Free

Research
CUHK Sees Atrial Fibrillation-related Stroke Cases 3 Times Higher Over 15 Years

CUHK Sees Atrial Fibrillation-related Stroke Cases 3 Times Higher Over 15 Years

Research
CUHK Professor Receives World Honour For Stroke Services Pioneering an Innovative 3-in-1 Multi-Target Therapy to Repair Damaged Brain After Stroke and Enhance Functional Recovery

CUHK Professor Receives World Honour For Stroke Services Pioneering an Innovative 3-in-1 Multi-Target Therapy to Repair Damaged Brain After Stroke and Enhance Functional Recovery

Awards and honors
CUHK Jointly Discovers New Therapeutic Solution for Minor Stroke in Global Study with over 30 Countries

CUHK Jointly Discovers New Therapeutic Solution for Minor Stroke in Global Study with over 30 Countries

Research
CUHK Sees Early Evaluation of TIA Patients Reduce Rate of Stroke by 70% in a Global Study of 21 Countries

CUHK Sees Early Evaluation of TIA Patients Reduce Rate of Stroke by 70% in a Global Study of 21 Countries

Research
CUHK Introduces High Frequency Oscillations to Determine Resection Margin Increases the Effectiveness of Complex Epilepsy Surgery by around 30%

CUHK Introduces High Frequency Oscillations to Determine Resection Margin Increases the Effectiveness of Complex Epilepsy Surgery by around 30%

Surgical advancement
CUHK Advocates Stringent Control of Cardiovascular Risks for Reopening of Narrowed Brain Arteries - A New Paradigm to Prevent Recurrent Stroke (Available in Chinese only)

CUHK Advocates Stringent Control of Cardiovascular Risks for Reopening of Narrowed Brain Arteries - A New Paradigm to Prevent Recurrent Stroke (Available in Chinese only)

Research
CUHK and PolyU Jointly Introduce TeleStroke for 24-hour Thrombolysis Service at Prince of Wales Hospital

CUHK and PolyU Jointly Introduce TeleStroke for 24-hour Thrombolysis Service at Prince of Wales Hospital

Clinical service
Inaugural Collaboration between CUHK and AstraZeneca on Diabetic Kidney Disease Research Advancing a Global Strategy Against Diabetic Kidney Disease

Inaugural Collaboration between CUHK and AstraZeneca on Diabetic Kidney Disease Research Advancing a Global Strategy Against Diabetic Kidney Disease

International collaboration
Chinese Women with Polycystic Ovarian Syndrome have 4-fold Higher Risk of Developing Diabetes

Chinese Women with Polycystic Ovarian Syndrome have 4-fold Higher Risk of Developing Diabetes

Research
Multicomponent Frailty Prevention Programme Reduces Frailty Over 80% of Pre-frail Elderly Reverse to Robust Phenotype

Multicomponent Frailty Prevention Programme Reduces Frailty Over 80% of Pre-frail Elderly Reverse to Robust Phenotype

Research
CUHK Study Suggests Preoperative Screening for Obstructive Sleep Apnoea to  Lower Risk of Postoperative Cardiovascular Events

CUHK Study Suggests Preoperative Screening for Obstructive Sleep Apnoea to Lower Risk of Postoperative Cardiovascular Events

Research
CUHK Study Proves Low-Dose Tricyclic Antidepressant (TCA) Effective in Treating Patients with Refractory Functional Dyspepsia

CUHK Study Proves Low-Dose Tricyclic Antidepressant (TCA) Effective in Treating Patients with Refractory Functional Dyspepsia

Research
CUHK Study Reveals 1 in 6 Diabetic Patients Project Rapid Renal Function Decline

CUHK Study Reveals 1 in 6 Diabetic Patients Project Rapid Renal Function Decline

Research
CUHK Studies Alert Mothers to Pregnancy Weight Gain

CUHK Studies Alert Mothers to Pregnancy Weight Gain

Research
CUHK Study Proves Achieving Sustained Minimal Disease Activity Lowers the Risk of Cardiovascular Diseases in Psoriatic Arthritis Patients

CUHK Study Proves Achieving Sustained Minimal Disease Activity Lowers the Risk of Cardiovascular Diseases in Psoriatic Arthritis Patients

Research
CUHK Study Sees Increasing Global Incidence of Colorectal Cancer Among Younger People

CUHK Study Sees Increasing Global Incidence of Colorectal Cancer Among Younger People

Research
CUHK Discovers an Essential Oncogene in Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma

CUHK Discovers an Essential Oncogene in Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma

Research
CUHK Study Reveals Patients with Recovery of Hepatitis B Still at Risk of Liver Cancer

CUHK Study Reveals Patients with Recovery of Hepatitis B Still at Risk of Liver Cancer

Research
CUHK Announces World’s First Systematic Review of the Global Incidence and Prevalence of Inflammatory Bowel Diseases in the 21st Century Reveals Surge in Hong Kong in past 30 years

CUHK Announces World’s First Systematic Review of the Global Incidence and Prevalence of Inflammatory Bowel Diseases in the 21st Century Reveals Surge in Hong Kong in past 30 years

Research
CUHK Proves Efficacy of Home-Based Management Approach of Obstructive Sleep Apnoea Applicable to 50% of Public Hospital Adult Cases with Waiting Time Reduced by 80%

CUHK Proves Efficacy of Home-Based Management Approach of Obstructive Sleep Apnoea Applicable to 50% of Public Hospital Adult Cases with Waiting Time Reduced by 80%

Research
CUHK Announces World’s First Meta-analysis on Prevalence of Helicobacter pylori Infection

CUHK Announces World’s First Meta-analysis on Prevalence of Helicobacter pylori Infection

Research
CUHK Recommends Oral Glucose Tolerance Test for All Pregnant Women Study Reveals Children of Women with Gestational Diabetes Mellitus Have 3-Fold Diabetes Risk

CUHK Recommends Oral Glucose Tolerance Test for All Pregnant Women Study Reveals Children of Women with Gestational Diabetes Mellitus Have 3-Fold Diabetes Risk

Research
CUHK Collaborates with Australian Experts to Untangle Mystery of Eastern Inflammatory Bowel Disease Gut Microbiota

CUHK Collaborates with Australian Experts to Untangle Mystery of Eastern Inflammatory Bowel Disease Gut Microbiota

Research
CUHK Reveals Non-Alcoholic Fatty Liver Disease Afflicts Even the Non-Obese

CUHK Reveals Non-Alcoholic Fatty Liver Disease Afflicts Even the Non-Obese

Research
CUHK Discovers Fatty Liver Causing Severe Liver Fibrosis or Cirrhosis in 1 Out of 5 Diabetic Patients

CUHK Discovers Fatty Liver Causing Severe Liver Fibrosis or Cirrhosis in 1 Out of 5 Diabetic Patients

Research
CUHK World’s First Study Confirms A New Colorectal Cancer High Risk Group

CUHK World’s First Study Confirms A New Colorectal Cancer High Risk Group

Research
CUHK and HKU Researchers Introduce 3D Printing Technology in Complex Cardiac Surgery Procedures

CUHK and HKU Researchers Introduce 3D Printing Technology in Complex Cardiac Surgery Procedures

Research
CUHK Conducts Hong Kong’s First Study on Seven Common Respiratory Viruses Revealing Respiratory Syncytial Virus and Influenza A as Prevalent Fatal Types

CUHK Conducts Hong Kong’s First Study on Seven Common Respiratory Viruses Revealing Respiratory Syncytial Virus and Influenza A as Prevalent Fatal Types

Research
Asia’s First Research by CUHK on Patients’ Lifestyle Reveals Personalised Modification Programme Effective in Reducing Severity of OSA

Asia’s First Research by CUHK on Patients’ Lifestyle Reveals Personalised Modification Programme Effective in Reducing Severity of OSA

Research
CUHK Latest Research Reveals FMT Effectiveness Triples that of Conventional Treatment

CUHK Latest Research Reveals FMT Effectiveness Triples that of Conventional Treatment

Research
CUHK Highlights the Significance of Hospital Infection Control System in Controlling MERS

CUHK Highlights the Significance of Hospital Infection Control System in Controlling MERS

Research
CUHK Latest Research Reveals over 100,000 New Non-alcoholic Fatty Liver Cases in Hong Kong Annually

CUHK Latest Research Reveals over 100,000 New Non-alcoholic Fatty Liver Cases in Hong Kong Annually

Research
CUHK Study Reveals Peer Support Can Reduce Hospital Admission of Distressed Diabetes Patients

CUHK Study Reveals Peer Support Can Reduce Hospital Admission of Distressed Diabetes Patients

Research
Screening Reveals Over 50% Community-dwelling Population Aged 65 or above are Pre-frail

Screening Reveals Over 50% Community-dwelling Population Aged 65 or above are Pre-frail

Research
CUHK Releases Research Results on Employment Status of Hong Kong Chronic Kidney Disease (CKD) Dialysis Patients and Promotes Predialysis Education Programme for Mid to Late Stage CKD patients

CUHK Releases Research Results on Employment Status of Hong Kong Chronic Kidney Disease (CKD) Dialysis Patients and Promotes Predialysis Education Programme for Mid to Late Stage CKD patients

Research
CUHK Announces Latest Medical Treatment for Minor Stroke

CUHK Announces Latest Medical Treatment for Minor Stroke

Research
Hong Kong and Macau Among Top Three Regions in Asia-Pacific with the Highest Incidence of Inflammatory Bowel Disease CUHK Establishes Registry to Increase Public Awareness

Hong Kong and Macau Among Top Three Regions in Asia-Pacific with the Highest Incidence of Inflammatory Bowel Disease CUHK Establishes Registry to Increase Public Awareness

Research
CUHK-HCC Score Accurately Predicts Risk of Liver Cancer in Chronic Hepatitis B Patients Receiving Antiviral Therapy

CUHK-HCC Score Accurately Predicts Risk of Liver Cancer in Chronic Hepatitis B Patients Receiving Antiviral Therapy

Research
CUHK Medical Student Unraveled Mystery of Neuronal Circuits Development

CUHK Medical Student Unraveled Mystery of Neuronal Circuits Development

Medical education
CUHK and Shanghai Jiao Tong University Discover Genetic Predictor of Diabetes in Chinese Patients

CUHK and Shanghai Jiao Tong University Discover Genetic Predictor of Diabetes in Chinese Patients

Research
CUHK Pioneers the Use of 3D Echocardiography to Identify At-Risk Mitral Valve Prolapse Patients

CUHK Pioneers the Use of 3D Echocardiography to Identify At-Risk Mitral Valve Prolapse Patients

Research
CUHK Advocates Palliative Care for Advanced Dementia Patients with Swallowing Problems

CUHK Advocates Palliative Care for Advanced Dementia Patients with Swallowing Problems

Research

Our Expert List

Many experts under the Faculty of Medicine are available for media interview.
Please click here for the expert list or contact us.