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https://www.med.cuhk.edu.hk/press-releases/cuhk-jointly-discovers-new-therapeutic-solution-for-minor-stroke-in-global-study-with-over-30-countries
https://www.med.cuhk.edu.hk/press-releases/cuhk-jointly-discovers-new-therapeutic-solution-for-minor-stroke-in-global-study-with-over-30-countries

CUHK Jointly Discovers New Therapeutic Solution for Minor Stroke in Global Study with over 30 Countries

Aspirin is currently the most commonly used drug to prevent recurrence of Transient Ischemic Attack (TIA) or minor stroke . However there has been concern about the associated risk of hemorrhagic events, such as bleeding in the brain and gut. A global study jointly led by The Chinese University of Hong Kong (CUHK) and neurology centres from over 30 countries has revealed that another antiplatelet agent ‘ticagrelor’ could potentially be an alternative drug to prevent recurrent stroke. Ticagrelor is found to be more effective than aspirin in preventing ischemic stroke. It can reduce the risk of recurrence by 13%. The findings were presented this month at the European Stroke Organization annual meeting in Barcelona and were published in a leading international journal, The New England Journal of Medicine.

 

Early evaluation of TIA patients helps reduce risk of another stroke by 70%

 

TIA, often labeled as a ‘mini-stroke’ and minor stroke, is commonly caused by the temporary blockage of blood vessels in the brain. This can cause sudden symptoms such as limb weakness or numbness, facial weakness, speech or visual disturbance. About 12% of patients with TIA or minor stroke will subsequently develop a more severe form of stroke after three months if they do not receive any early treatment. It was revealed in an international study jointly led by CUHK last month that early assessment and treatment in specialized centers were shown to reduce the risk of another stroke by 70%.

 

Coherently, the captioned study reviewed therapeutic trial on minor stroke patients within 24 hours of onset of symptom to reduce the risk of recurrence of stroke. The SOCRATES study involved 674 neurology centres from 33 countries. Data on over 13,000 patients, including 97 in Hong Kong, was collected, of whom half took aspirin and the other half took ticagrelor within 24 hours of onset of minor stroke or acute ischemic stroke, to compare the effectiveness of both drug treatments. The patients were followed for three months.

 

Ticagrelor more effective than Aspirin in reducing ischemic stroke

 

Study results are divided into primary and secondary outcomes. The primary outcome event (a composite of stroke, heart attack and death) occurs in 7.5% in the aspirin group and 6.8% in the ticagrelor group, which represent an 11% risk reduction. The first secondary outcome event (ischemic stroke) occurs in 6.6% in the aspirin group and 5.9% in the ticagrelor group, which represent a 13% risk reduction. Ticagrelor does not appear to be significant in reducing the composite of stroke, heart attack and death compared to aspirin. However, there were indications that this drug may be more effective in reducing ischemic stroke and all strokes.

 

Prof. Lawrence Ka Sing WONG, Mok Hing Yiu Professor of Medicine, Head of Division of Neurology, Department of Medicine and Therapeutics at CUHK added, ‘The benefits of ticagrelor over aspirin were more obvious in four groups of patients. The first group was of patients who were already taking aspirin when they developed a stroke or TIA, meaning that aspirin might not be strong enough to inhibit platelet aggregation in this special group of patients. Other groups that showed benefits included those patients who were treated early within 12 hours of the onset of symptoms, aged below 65 and Asians.’

 

Lifestyle modifications are as important to prevent recurrence of stroke

 

Every year, there are more than 3,000 patients attending public hospitals for TIA or mild stroke in Hong Kong. At the Prince of Wales Hospital, there are 230 cases of suspected TIA and 550 cases of mild stroke per year.

 

Dr. Florence FAN, Adjunct Tutor, Department of Medicine and Therapeutics, Faculty of Medicine, remarked, ‘The usual drug treatment to prevent another stroke includes the use of antiplatelet drug, such as aspirin, because it inhibits formation of platelet aggregation in the artery. Other useful drugs include statin to lower cholesterol and drug to treat hypertension. There are other important but often neglected treatments in the prevention of recurrent stroke -- abstinence from smoking or drinking, regular exercise and dietary restrictions. Stroke survivors should be educated on these measures in lifestyle modifications.’

 

Professor Wong also highlighted that many patients had another stroke within 24 hours of the first event so it is important for them to come to the emergency room as soon as possible. He reminded the public to be more aware of the different severe forms of stroke and remember the slogan ‘ACT F.A.S.T’:

  • Face Drooping – Does one side of the face droop or is it numb? Ask the person to smile. Is the person's smile uneven?
  • Arm Weakness – Is one arm weak or numb? Ask the person to raise both arms.  Does one arm drift downward?
  • Speech Difficulty – Is speech slurred? Is the person unable to speak or hard to understand? Ask the person to repeat a simple sentence, like "The sky is blue." Is the sentence repeated correctly?
  • Time to call 999 – If someone shows any of these symptoms, even if the symptoms go away, call 999 and get the person to the hospital immediately.

 

A global study jointly led by CUHK with other neurology centres

A global study jointly led by CUHK with other neurology centres discovers new therapeutic solution for minor stroke. Prof. Lawrence WONG, Head of Division of Neurology, Department of Medicine and Therapeutics (Left) and Dr. Florence FAN, Adjunct Tutor of the Department, CUHK.

Prof. Lawrence WONG says

Prof. Lawrence WONG says the new antiplatelet agent Ticagrelor is more effective than aspirin in preventing ischemic stroke.

Dr. Florence FAN reminds minor stroke

Dr. Florence FAN reminds minor stroke or stroke patients to take measures in lifestyle modifications to prevent another stroke.

Mr. Wu describes the left side of his body

Mr. Wu (middle) describes the left side of his body felt numb when he had a minor stroke, like being ‘possessed by a spirit’.

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CUHK Survey Reveals Relationship between Exercise Pattern and Emotional Health among Hong Kong People Mind-body Exercise Helps Reduce Risk of Mood Disorders

Research
CUHK Establishes State Key Laboratory of Digestive Disease to Improve Diagnosis and Treatment of Digestive Diseases

CUHK Establishes State Key Laboratory of Digestive Disease to Improve Diagnosis and Treatment of Digestive Diseases

Research
CUHK Conducts Asia's Largest Clinical Study on Life-threatening Infections caused by RSV and Influenza in Hong Kong Adults and Elderly

CUHK Conducts Asia's Largest Clinical Study on Life-threatening Infections caused by RSV and Influenza in Hong Kong Adults and Elderly

Research
CUHK Assessed and Treated Over 300 Young Ketamine Abusers with Urinary Tract Dysfunction Latest Research Reveals Effectiveness of Integrated Anti-inflammatory Therapy

CUHK Assessed and Treated Over 300 Young Ketamine Abusers with Urinary Tract Dysfunction Latest Research Reveals Effectiveness of Integrated Anti-inflammatory Therapy

Research
CUHK Research Reveals that Physical and Cognitive Activities can Maintain and Improve Brain Functions of Patients with Mild Cognitive Impairments

CUHK Research Reveals that Physical and Cognitive Activities can Maintain and Improve Brain Functions of Patients with Mild Cognitive Impairments

Research
CUHK Launches Territory-wide Screening Study for Early Detection of Nasopharynx Cancer Now Recruiting 20,000 Citizens to Join

CUHK Launches Territory-wide Screening Study for Early Detection of Nasopharynx Cancer Now Recruiting 20,000 Citizens to Join

Research
CUHK Research Reveals Impact of Mild Hearing Loss on School Children Now Recruiting Hearing Impaired Students for Research on Efficacy of Intervention

CUHK Research Reveals Impact of Mild Hearing Loss on School Children Now Recruiting Hearing Impaired Students for Research on Efficacy of Intervention

Research
CUHK-HCC Score Accurately Predicts Risk of Liver Cancer in Chronic Hepatitis B Patients Receiving Antiviral Therapy

CUHK-HCC Score Accurately Predicts Risk of Liver Cancer in Chronic Hepatitis B Patients Receiving Antiviral Therapy

Research
CUHK and Shanghai Jiao Tong University Discover Genetic Predictor of Diabetes in Chinese Patients

CUHK and Shanghai Jiao Tong University Discover Genetic Predictor of Diabetes in Chinese Patients

Research
CUHK Pioneers the Use of 3D Echocardiography to Identify At-Risk Mitral Valve Prolapse Patients

CUHK Pioneers the Use of 3D Echocardiography to Identify At-Risk Mitral Valve Prolapse Patients

Research
CUHK discovers that 40% of Individuals at Risk of Coronary Heart Disease have Pre-cancerous Bowel Tumors

CUHK discovers that 40% of Individuals at Risk of Coronary Heart Disease have Pre-cancerous Bowel Tumors

Research
CUHK Advocates Palliative Care for Advanced Dementia Patients with Swallowing Problems

CUHK Advocates Palliative Care for Advanced Dementia Patients with Swallowing Problems

Research
CUHK Develops an Automatic Retinal Image Analysis System to Help Diabetes Patients and Elderly Prevent Stroke

CUHK Develops an Automatic Retinal Image Analysis System to Help Diabetes Patients and Elderly Prevent Stroke

Research
CUHK Study Reveals High Salt Intake Will Lead to High Blood Pressure and Higher Risk of Stroke

CUHK Study Reveals High Salt Intake Will Lead to High Blood Pressure and Higher Risk of Stroke

Research
CUHK Launches Territory-wide Sleep Health Education Campaign to Promote Healthy Sleep and Healthy School Life

CUHK Launches Territory-wide Sleep Health Education Campaign to Promote Healthy Sleep and Healthy School Life

Health Campaign
CUHK and HKU's Collaborative Research Discovers Novel Epilepsy Genetic Markers

CUHK and HKU's Collaborative Research Discovers Novel Epilepsy Genetic Markers

Research
CUHK Advocates Early Detection of Chronic Kidney Diseases Joined by Leading Nephrologists to Make Sound Recommendations

CUHK Advocates Early Detection of Chronic Kidney Diseases Joined by Leading Nephrologists to Make Sound Recommendations

Research
CUHK Research Findings on Severe Human Swine Flu in Hong Kong

CUHK Research Findings on Severe Human Swine Flu in Hong Kong

Research

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