Search
What are you looking for?
Start main content

Press Releases

Press Releases

https://www.med.cuhk.edu.hk/press-releases/cuhk-and-shanghai-jiao-tong-university-discover-genetic-predictor-of-diabetes-in-chinese-patients
https://www.med.cuhk.edu.hk/press-releases/cuhk-and-shanghai-jiao-tong-university-discover-genetic-predictor-of-diabetes-in-chinese-patients

CUHK and Shanghai Jiao Tong University Discover Genetic Predictor of Diabetes in Chinese Patients

A research team led by Professor Ronald Ching Wan MA and Professor Juliana Chung Ngor CHAN from the Division of Endocrinology and Diabetes, Department of Medicine and Therapeutics at The Chinese University of Hong Kong (CUHK), as well as Dr Wing Yee SO, Clinical Associate Professor (Honorary) from the same Department, has successfully discovered a genetic predictor of diabetes among Chinese patients, which may help to identify high-risk individuals, in a collaborative study with Shanghai Jiao Tong University (SJTU) Affiliated Sixth People's Hospital. The findings have been published on-line in the prestigious international journal, Diabetologia.

 

From Left) Professor Ronald Ching Wan MA, Professor, Division of Endocrinology and Diabetes, Department of Medicine and Therapeutics; Professor Juliana Chung Ngor CHAN; Dr Wing Yee SO, Clinical Associate Professor (Honorary), Department of Medicine and Therapeutics at CUHK

From Left) Professor Ronald Ching Wan MA, Professor, Division of Endocrinology and Diabetes, Department of Medicine and Therapeutics; Professor Juliana Chung Ngor CHAN; Dr Wing Yee SO, Clinical Associate Professor (Honorary), Department of Medicine and Therapeutics at CUHK

Statistics from the Department of Health have shown that Diabetes mellitus remains one of the top ten causes of death in Hong Kong. In 2011, 457 registered deaths were caused by diabetes, among which over 40% were men. Currently, there are approximately 700,000 people suffering from diabetes in Hong Kong, representing 10% of the total population; while there are around 90 million people with diabetes and 148 million with pre-diabetes in mainland China. Diabetes increases the risk of heart disease and kidney failure by two to four times. In recent years, the discovery of genetic markers for diabetes has helped identify high-risk individuals, however, most of these genetic markers were identified in non-Chinese populations and therefore may not apply to Chinese people.

Researchers from CUHK and SJTU jointly conducted a study from 2008 to 2012 to identify genetic predictors of diabetes in the Chinese population. The team systematically surveyed over 2.9 million markers across the genome in 684 Chinese subjects with diabetes (mean age 52.4 years old) and 955 subjects without diabetes. Selected genetic markers were followed up and genotyped in another 10,383 Chinese subjects with diabetes and 6,974 control subjects to find out their association with diabetes. The team finally identified a genetic marker on chromosome 7 near the paired box gene 4 (PAX4) gene which was associated with diabetes as well as poorer insulin response. . People with this genetic marker have approximately 18% higher risk for diabetes and will develop diabetes at a younger age.  This genetic risk association was also confirmed by collaborators in East Asian countries including Japan and Korea, as well as in Europe.

Professor Ronald Ma remarked, "Patients in Asia tend to develop diabetes at a younger age. It is now clear that people with diabetes have insufficient insulin response to maintain blood glucose level. We are very excited to have discovered this genetic marker which have not only identified high-risk diabetes patients, but also those with insufficient beta-cell function who may develop diabetes at a younger age. Early intervention by changing lifestyle or intensifying treatment will be particularly important for these high-risk individuals. The study also highlights the importance of international collaborations in large-scale genetic research."

Dr Wing Yee So noted, "Great variations were found in the gene region we studied between the Chinese and European population, that is why this marker has not been found in earlier studies done in Europe."

"The genetic markers provide an excellent foundation for the development of personalized medicine of diabetes and similar diseases with multiple causes", remarked Professor Juliana Chan, "It provides important insights into the cause of diabetes and identifies high risk patients for early intervention. The interactions between genetic markers and treatment responses will also guide us to select the most appropriate intervention."

Parts of the study done in Hong Kong were supported by the Hong Kong Foundation for Research and Development in Diabetes, The Hong Kong Government Research Grants Council, The Innovation and Technology Fund, a grant from National Institutes of Health, CUHK Focused Investment Grant, the Research Fund of the Department of Medicine and Therapeutics and the Li Ka Shing Institute of Health Sciences, CUHK.

More Press Releases

CU Medicine Studies Reveal Diabetes Death and Complication Rates Declining - but Not in the Young

CU Medicine Studies Reveal Diabetes Death and Complication Rates Declining - but Not in the Young

Research
CU Medicine Researchers Discover Shortened DNA Telomere Length as a Useful Biomarker to Identify Patients with Diabetes at High Risk of Cardiovascular Disease

CU Medicine Researchers Discover Shortened DNA Telomere Length as a Useful Biomarker to Identify Patients with Diabetes at High Risk of Cardiovascular Disease

Research
Inaugural Collaboration between CUHK and AstraZeneca on Diabetic Kidney Disease Research Advancing a Global Strategy Against Diabetic Kidney Disease

Inaugural Collaboration between CUHK and AstraZeneca on Diabetic Kidney Disease Research Advancing a Global Strategy Against Diabetic Kidney Disease

International collaboration
Chinese Women with Polycystic Ovarian Syndrome have 4-fold Higher Risk of Developing Diabetes

Chinese Women with Polycystic Ovarian Syndrome have 4-fold Higher Risk of Developing Diabetes

Research
CUHK Study Reveals 1 in 6 Diabetic Patients Project Rapid Renal Function Decline

CUHK Study Reveals 1 in 6 Diabetic Patients Project Rapid Renal Function Decline

Research
CUHK Recommends Oral Glucose Tolerance Test for All Pregnant Women Study Reveals Children of Women with Gestational Diabetes Mellitus Have 3-Fold Diabetes Risk

CUHK Recommends Oral Glucose Tolerance Test for All Pregnant Women Study Reveals Children of Women with Gestational Diabetes Mellitus Have 3-Fold Diabetes Risk

Research
CUHK Study Reveals Peer Support Can Reduce Hospital Admission of Distressed Diabetes Patients

CUHK Study Reveals Peer Support Can Reduce Hospital Admission of Distressed Diabetes Patients

Research
CUHK and International Experts in Diabetes Care Joined Hands for Four Years Developing a Multicomponent, Integrated Strategy for Diabetes under The Lancet

CUHK and International Experts in Diabetes Care Joined Hands for Four Years Developing a Multicomponent, Integrated Strategy for Diabetes under The Lancet

International collaboration
Two CUHK Scholars from the Faculty of Medicine Receive Croucher Senior Medical Research Fellowships

Two CUHK Scholars from the Faculty of Medicine Receive Croucher Senior Medical Research Fellowships

Awards and honors
CUHK Medicine Professor Juliana Chan Receives International Honour for  Outstanding Research and Care in Diabetes

CUHK Medicine Professor Juliana Chan Receives International Honour for Outstanding Research and Care in Diabetes

Awards and honors
CUHK Studies Alert Mothers to Pregnancy Weight Gain

CUHK Studies Alert Mothers to Pregnancy Weight Gain

Research
CUHK Discovers Fatty Liver Causing Severe Liver Fibrosis or Cirrhosis in 1 Out of 5 Diabetic Patients

CUHK Discovers Fatty Liver Causing Severe Liver Fibrosis or Cirrhosis in 1 Out of 5 Diabetic Patients

Research
40% of Hong Kong People Show Gut Dysbiosis Comparable to that of COVID-19 Patients CUHK Microbiome Immunity Formula Hastens Recovery of COVID-19 Patients and Offers Hope to Boost Immunity

40% of Hong Kong People Show Gut Dysbiosis Comparable to that of COVID-19 Patients CUHK Microbiome Immunity Formula Hastens Recovery of COVID-19 Patients and Offers Hope to Boost Immunity

Research
CU Medicine Study Shows Liver Injury is Common and Prognostic in COVID-19 Patients

CU Medicine Study Shows Liver Injury is Common and Prognostic in COVID-19 Patients

Research
CUHK Researchers Uncover Diabetes as a Potential Risk Factor for COVID-19,  and Possible Mechanisms

CUHK Researchers Uncover Diabetes as a Potential Risk Factor for COVID-19, and Possible Mechanisms

Research
Multicomponent Frailty Prevention Programme Reduces Frailty Over 80% of Pre-frail Elderly Reverse to Robust Phenotype

Multicomponent Frailty Prevention Programme Reduces Frailty Over 80% of Pre-frail Elderly Reverse to Robust Phenotype

Research
CUHK Launches a Population-based Programme to Evaluate and Track Brain Health Status  of 5,000 Hong Kong Residents for Free

CUHK Launches a Population-based Programme to Evaluate and Track Brain Health Status of 5,000 Hong Kong Residents for Free

Research
CUHK Study Suggests Preoperative Screening for Obstructive Sleep Apnoea to  Lower Risk of Postoperative Cardiovascular Events

CUHK Study Suggests Preoperative Screening for Obstructive Sleep Apnoea to Lower Risk of Postoperative Cardiovascular Events

Research
CUHK Establishes Margaret K.L. Cheung Research Centre for Management of Parkinsonism  To Develop Innovative Solutions to Slow Disease Progression

CUHK Establishes Margaret K.L. Cheung Research Centre for Management of Parkinsonism To Develop Innovative Solutions to Slow Disease Progression

Research
CUHK Conducts World’s First Family Study on Rapid Eye Movement Sleep Behaviour Disorder to Investigate Familial Link with Parkinson’s Disease

CUHK Conducts World’s First Family Study on Rapid Eye Movement Sleep Behaviour Disorder to Investigate Familial Link with Parkinson’s Disease

Research
CUHK Study Proves Low-Dose Tricyclic Antidepressant (TCA) Effective in Treating Patients with Refractory Functional Dyspepsia

CUHK Study Proves Low-Dose Tricyclic Antidepressant (TCA) Effective in Treating Patients with Refractory Functional Dyspepsia

Research
CUHK Study Proves Achieving Sustained Minimal Disease Activity Lowers the Risk of Cardiovascular Diseases in Psoriatic Arthritis Patients

CUHK Study Proves Achieving Sustained Minimal Disease Activity Lowers the Risk of Cardiovascular Diseases in Psoriatic Arthritis Patients

Research
CUHK Study Sees Increasing Global Incidence of Colorectal Cancer Among Younger People

CUHK Study Sees Increasing Global Incidence of Colorectal Cancer Among Younger People

Research
CUHK Pioneers in Developing Standardised Tests for Screening Cognitive Impairment in the Ageing Population in Hong Kong

CUHK Pioneers in Developing Standardised Tests for Screening Cognitive Impairment in the Ageing Population in Hong Kong

Clinical service
CUHK Discovers an Essential Oncogene in Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma

CUHK Discovers an Essential Oncogene in Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma

Research
CUHK Study Reveals Patients with Recovery of Hepatitis B Still at Risk of Liver Cancer

CUHK Study Reveals Patients with Recovery of Hepatitis B Still at Risk of Liver Cancer

Research
CUHK Announces World’s First Systematic Review of the Global Incidence and Prevalence of Inflammatory Bowel Diseases in the 21st Century Reveals Surge in Hong Kong in past 30 years

CUHK Announces World’s First Systematic Review of the Global Incidence and Prevalence of Inflammatory Bowel Diseases in the 21st Century Reveals Surge in Hong Kong in past 30 years

Research
CUHK Launches World’s First Study Utilizing Retinal Imaging for Alzheimer’s Disease Screening in Chinese Population

CUHK Launches World’s First Study Utilizing Retinal Imaging for Alzheimer’s Disease Screening in Chinese Population

Research
CUHK Sees Atrial Fibrillation-related Stroke Cases 3 Times Higher Over 15 Years

CUHK Sees Atrial Fibrillation-related Stroke Cases 3 Times Higher Over 15 Years

Research
CUHK Proves Efficacy of Home-Based Management Approach of Obstructive Sleep Apnoea Applicable to 50% of Public Hospital Adult Cases with Waiting Time Reduced by 80%

CUHK Proves Efficacy of Home-Based Management Approach of Obstructive Sleep Apnoea Applicable to 50% of Public Hospital Adult Cases with Waiting Time Reduced by 80%

Research
CUHK Announces World’s First Meta-analysis on Prevalence of Helicobacter pylori Infection

CUHK Announces World’s First Meta-analysis on Prevalence of Helicobacter pylori Infection

Research
CUHK Collaborates with Australian Experts to Untangle Mystery of Eastern Inflammatory Bowel Disease Gut Microbiota

CUHK Collaborates with Australian Experts to Untangle Mystery of Eastern Inflammatory Bowel Disease Gut Microbiota

Research
CUHK Reveals Non-Alcoholic Fatty Liver Disease Afflicts Even the Non-Obese

CUHK Reveals Non-Alcoholic Fatty Liver Disease Afflicts Even the Non-Obese

Research
CUHK Professor Receives World Honour For Stroke Services Pioneering an Innovative 3-in-1 Multi-Target Therapy to Repair Damaged Brain After Stroke and Enhance Functional Recovery

CUHK Professor Receives World Honour For Stroke Services Pioneering an Innovative 3-in-1 Multi-Target Therapy to Repair Damaged Brain After Stroke and Enhance Functional Recovery

Awards and honors
CUHK Opens Therese Pei Fong Chow Research Centre for Prevention of Dementia and Establishes a One-stop Online Platform to Provide Information on Dementia

CUHK Opens Therese Pei Fong Chow Research Centre for Prevention of Dementia and Establishes a One-stop Online Platform to Provide Information on Dementia

Research
CUHK World’s First Study Confirms A New Colorectal Cancer High Risk Group

CUHK World’s First Study Confirms A New Colorectal Cancer High Risk Group

Research
CUHK Sets up the Global First Research Registry on Early Onset Dementia in Chinese Population

CUHK Sets up the Global First Research Registry on Early Onset Dementia in Chinese Population

Research
CUHK and HKU Researchers Introduce 3D Printing Technology in Complex Cardiac Surgery Procedures

CUHK and HKU Researchers Introduce 3D Printing Technology in Complex Cardiac Surgery Procedures

Research
CUHK Jointly Discovers New Therapeutic Solution for Minor Stroke in Global Study with over 30 Countries

CUHK Jointly Discovers New Therapeutic Solution for Minor Stroke in Global Study with over 30 Countries

Research
CUHK Sees Early Evaluation of TIA Patients Reduce Rate of Stroke by 70% in a Global Study of 21 Countries

CUHK Sees Early Evaluation of TIA Patients Reduce Rate of Stroke by 70% in a Global Study of 21 Countries

Research
CUHK Conducts Hong Kong’s First Study on Seven Common Respiratory Viruses Revealing Respiratory Syncytial Virus and Influenza A as Prevalent Fatal Types

CUHK Conducts Hong Kong’s First Study on Seven Common Respiratory Viruses Revealing Respiratory Syncytial Virus and Influenza A as Prevalent Fatal Types

Research
Asia’s First Research by CUHK on Patients’ Lifestyle Reveals Personalised Modification Programme Effective in Reducing Severity of OSA

Asia’s First Research by CUHK on Patients’ Lifestyle Reveals Personalised Modification Programme Effective in Reducing Severity of OSA

Research
CUHK Screening Reveals 1 in 3 Older Adults in Community Suffer Brain Small Vessel Disease, Early Prevention Recommended

CUHK Screening Reveals 1 in 3 Older Adults in Community Suffer Brain Small Vessel Disease, Early Prevention Recommended

Clinical service
CUHK Latest Research Reveals FMT Effectiveness Triples that of Conventional Treatment

CUHK Latest Research Reveals FMT Effectiveness Triples that of Conventional Treatment

Research
CUHK Introduces High Frequency Oscillations to Determine Resection Margin Increases the Effectiveness of Complex Epilepsy Surgery by around 30%

CUHK Introduces High Frequency Oscillations to Determine Resection Margin Increases the Effectiveness of Complex Epilepsy Surgery by around 30%

Surgical advancement
CUHK Highlights the Significance of Hospital Infection Control System in Controlling MERS

CUHK Highlights the Significance of Hospital Infection Control System in Controlling MERS

Research
CUHK Advocates Stringent Control of Cardiovascular Risks for Reopening of Narrowed Brain Arteries - A New Paradigm to Prevent Recurrent Stroke (Available in Chinese only)

CUHK Advocates Stringent Control of Cardiovascular Risks for Reopening of Narrowed Brain Arteries - A New Paradigm to Prevent Recurrent Stroke (Available in Chinese only)

Research
CUHK Latest Research Reveals over 100,000 New Non-alcoholic Fatty Liver Cases in Hong Kong Annually

CUHK Latest Research Reveals over 100,000 New Non-alcoholic Fatty Liver Cases in Hong Kong Annually

Research
Joint Study by CUHK and HKSH Reveals Patients with Comorbid REM Sleep Behavior Disorder and Depression may Suffer from Early-stage Neurodegeneration

Joint Study by CUHK and HKSH Reveals Patients with Comorbid REM Sleep Behavior Disorder and Depression may Suffer from Early-stage Neurodegeneration

Research
CUHK Advocates Atrial Fibrillation Screening and Drug Education to Reduce Risk of Stroke among Elderly

CUHK Advocates Atrial Fibrillation Screening and Drug Education to Reduce Risk of Stroke among Elderly

Clinical service
Screening Reveals Over 50% Community-dwelling Population Aged 65 or above are Pre-frail

Screening Reveals Over 50% Community-dwelling Population Aged 65 or above are Pre-frail

Research
CUHK and PolyU Jointly Introduce TeleStroke for 24-hour Thrombolysis Service at Prince of Wales Hospital

CUHK and PolyU Jointly Introduce TeleStroke for 24-hour Thrombolysis Service at Prince of Wales Hospital

Clinical service
CUHK Releases Research Results on Employment Status of Hong Kong Chronic Kidney Disease (CKD) Dialysis Patients and Promotes Predialysis Education Programme for Mid to Late Stage CKD patients

CUHK Releases Research Results on Employment Status of Hong Kong Chronic Kidney Disease (CKD) Dialysis Patients and Promotes Predialysis Education Programme for Mid to Late Stage CKD patients

Research
CUHK Announces Latest Medical Treatment for Minor Stroke

CUHK Announces Latest Medical Treatment for Minor Stroke

Research
Hong Kong and Macau Among Top Three Regions in Asia-Pacific with the Highest Incidence of Inflammatory Bowel Disease CUHK Establishes Registry to Increase Public Awareness

Hong Kong and Macau Among Top Three Regions in Asia-Pacific with the Highest Incidence of Inflammatory Bowel Disease CUHK Establishes Registry to Increase Public Awareness

Research
CUHK-HCC Score Accurately Predicts Risk of Liver Cancer in Chronic Hepatitis B Patients Receiving Antiviral Therapy

CUHK-HCC Score Accurately Predicts Risk of Liver Cancer in Chronic Hepatitis B Patients Receiving Antiviral Therapy

Research
CUHK Pioneers the Use of 3D Echocardiography to Identify At-Risk Mitral Valve Prolapse Patients

CUHK Pioneers the Use of 3D Echocardiography to Identify At-Risk Mitral Valve Prolapse Patients

Research
CUHK Advocates Palliative Care for Advanced Dementia Patients with Swallowing Problems

CUHK Advocates Palliative Care for Advanced Dementia Patients with Swallowing Problems

Research

Our Expert List

Many experts under the Faculty of Medicine are available for media interview.
Please click here for the expert list or contact us.