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https://www.med.cuhk.edu.hk/press-releases/cu-medicine-proves-oral-antivirals-for-covid-19-can-lower-the-risk-of-hospitalisation-and-inpatient-progression-in-older-patients-living-in-nursing-homes
https://www.med.cuhk.edu.hk/press-releases/cu-medicine-proves-oral-antivirals-for-covid-19-can-lower-the-risk-of-hospitalisation-and-inpatient-progression-in-older-patients-living-in-nursing-homes

CU Medicine proves oral antivirals for COVID-19 can lower the risk of hospitalisation and inpatient progression in older patients living in nursing homes

Covid-19 oral drug study

CU Medicine analysed data of 14,000 patients with COVID-19 living in nursing homes, proving two oral antivirals Molnupiravir and Nirmatrelvir/ Ritonavir, known as Paxlovid, are effective in lowering the risk of hospitalisation by 54% and the risk of inpatient disease progression by 65-83%. The research team believes the results provide strong evidence to encourage older patients, both in nursing homes and in the community, to seek medical assistance and take oral antivirals as soon as they get infected. (From left) Dr Bosco Ma Hon-ming, Associate Professor (Honorary) ; Dr Terry YipCheuk-fung, Assistant Professor and Assistant Director of Medical Data Analytics Centre; and Professor Grace Wong Lai-hung, Professor and Director of Medical Data Analytics Centre, from the Department of Medicine and Therapeutics at CU Medicine.

The Department of Health announced recently that the widespread use of oral antiviral drugs helped reduce the threat of SARS-CoV-2 infections. The Chinese University of Hong Kong’s (CUHK) Faculty of Medicine (CU Medicine) analysed data of 14,000 patients with COVID-19 living in nursing homes, proving two oral antivirals Molnupiravir and Nirmatrelvir/ Ritonavir, known as Paxlovid, are effective in lowering the risk of hospitalisation by 54% and the risk of inpatient disease progression by 65-83%. The research team believes the results provide strong evidence to encourage older patients, both in nursing homes and in the community, to seek medical assistance and take oral antivirals as soon as they get infected. Details of the study have been published in the international journal JAMA Network Open.

 

Data to evaluate efficacy of COVID-19 antivirals for older and frail patients is insufficient

 

Previous international studies have proved Molnupiravir and Nirmatrelvir/ Ritonavir are effective in lowering the risk of hospitalisation or death, but data was mainly based on the young to middle-aged group and lacked that from older and frail patients.    

 

Professor Grace Wong Lai-hung, Professor of the Department of Medicine and Therapeutics and Director of Medical Data Analytics Centre (MDAC) at CU Medicine, said, “Old people living in nursing homes are usually older and frailer than their community-dwelling counterparts, and some may be suffering from co-morbidities and disability. Thus, they have a higher risk of death or poor progression if they are infected with SARS-CoV-2. COVID-19 outbreaks in residential care homes for the elderly (RCHEs) caused significant morbidity and mortality during the 5th epidemic in Hong Kong. We therefore carried out this study to see if the two oral antivirals are effective in reducing the risk of hospitalisation or inpatient disease progression among older patients.” 

 

Both studied antivirals can lower the risk of hospitalisation and inpatient progression in older patients

 

CU Medicine collected and analysed data of 14,617 patients living in nursing homes who got infected with SARS-CoV-2 between February and March 2022. The average age of the study subjects was 83-85. One-third of them (35.5%) were prescribed with Molnupiravir, 3.3% used Nirmatrelvir/ Ritonavir, and the remaining 61.2% did not use oral antivirals. With a follow-up of 30 days on average, researchers found that the risk of hospitalisation dropped by 54% and the risk of inpatient disease progression was reduced by 65-83% after the patient had taken oral antivirals.

 

Dr Terry Yip Cheuk-fung, Assistant Professor of the Department of Medicine and Therapeutics and Assistant Director of MDAC at CU Medicine, said, “Study results showed both Molnupiravir and Nirmatrelvir/ Ritonavir can lower the risk of hospitalisation for older patients. And for inpatients, the antivirals are effective in reducing the risk of disease progression.”

 

Dr Bosco Ma Hon-ming, Associate Professor (Honorary) of the Division of Geriatrics, Department of Medicine and Therapeutics at CU Medicine, concluded, “Our study was conducted at the peak of the fifth wave of COVID-19 in Hong Kong. The results have substantial clinical significance in managing patients with COVID-19 in RCHEs. According to the statistics of Department of Health, reinfection rate in RCHEs is as high as 70%. We appeal to medical professionals to prescribe oral antivirals for patients in RCHEs in order to relieve their illness and alleviate the burden on the  healthcare system. We are grateful to have the support of the Hospital Authority Head Office, seven clusters, and 15 community geriatric assessment teams in combatting COVID-19 in RCHEs and for this research.”

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Research
Joint Study by CUHK and HKSH Reveals Patients with Comorbid REM Sleep Behavior Disorder and Depression may Suffer from Early-stage Neurodegeneration

Joint Study by CUHK and HKSH Reveals Patients with Comorbid REM Sleep Behavior Disorder and Depression may Suffer from Early-stage Neurodegeneration

Research
CUHK Advocates Atrial Fibrillation Screening and Drug Education to Reduce Risk of Stroke among Elderly

CUHK Advocates Atrial Fibrillation Screening and Drug Education to Reduce Risk of Stroke among Elderly

Clinical service
Screening Reveals Over 50% Community-dwelling Population Aged 65 or above are Pre-frail

Screening Reveals Over 50% Community-dwelling Population Aged 65 or above are Pre-frail

Research
Risk of Diabetes Patients Having Depression Doubles That of the General Public CUHK Advocates Timely Assessment of Diabetes Patients’ Mental Health Conditions

Risk of Diabetes Patients Having Depression Doubles That of the General Public CUHK Advocates Timely Assessment of Diabetes Patients’ Mental Health Conditions

Research
Radiotherapy to Head and Neck Raises Risk for Stroke CUHK Proved Effectiveness of Carotid Angioplasty and Stenting

Radiotherapy to Head and Neck Raises Risk for Stroke CUHK Proved Effectiveness of Carotid Angioplasty and Stenting

Research
CUHK and PolyU Jointly Introduce TeleStroke for 24-hour Thrombolysis Service at Prince of Wales Hospital

CUHK and PolyU Jointly Introduce TeleStroke for 24-hour Thrombolysis Service at Prince of Wales Hospital

Clinical service
CUHK Releases Research Results on Employment Status of Hong Kong Chronic Kidney Disease (CKD) Dialysis Patients and Promotes Predialysis Education Programme for Mid to Late Stage CKD patients

CUHK Releases Research Results on Employment Status of Hong Kong Chronic Kidney Disease (CKD) Dialysis Patients and Promotes Predialysis Education Programme for Mid to Late Stage CKD patients

Research
CUHK Announces Latest Medical Treatment for Minor Stroke

CUHK Announces Latest Medical Treatment for Minor Stroke

Research
Hong Kong and Macau Among Top Three Regions in Asia-Pacific with the Highest Incidence of Inflammatory Bowel Disease CUHK Establishes Registry to Increase Public Awareness

Hong Kong and Macau Among Top Three Regions in Asia-Pacific with the Highest Incidence of Inflammatory Bowel Disease CUHK Establishes Registry to Increase Public Awareness

Research
CUHK Assessed and Treated Over 300 Young Ketamine Abusers with Urinary Tract Dysfunction Latest Research Reveals Effectiveness of Integrated Anti-inflammatory Therapy

CUHK Assessed and Treated Over 300 Young Ketamine Abusers with Urinary Tract Dysfunction Latest Research Reveals Effectiveness of Integrated Anti-inflammatory Therapy

Research
CUHK and Shanghai Jiao Tong University Discover Genetic Predictor of Diabetes in Chinese Patients

CUHK and Shanghai Jiao Tong University Discover Genetic Predictor of Diabetes in Chinese Patients

Research
CUHK Pioneers the Use of 3D Echocardiography to Identify At-Risk Mitral Valve Prolapse Patients

CUHK Pioneers the Use of 3D Echocardiography to Identify At-Risk Mitral Valve Prolapse Patients

Research
CUHK Advocates Palliative Care for Advanced Dementia Patients with Swallowing Problems

CUHK Advocates Palliative Care for Advanced Dementia Patients with Swallowing Problems

Research
CUHK Pioneers the Use of a New Non-Invasive Imaging Technology to Measure Fatty Liver - a problem affecting 27% of the adult population in HK

CUHK Pioneers the Use of a New Non-Invasive Imaging Technology to Measure Fatty Liver - a problem affecting 27% of the adult population in HK

Research
Antiviral Therapy Can Prevent Liver Cancer Recurrence CUHK Represents HK to Draw Up Asian Pacific Treatment Guideline for Chronic Hepatitis B

Antiviral Therapy Can Prevent Liver Cancer Recurrence CUHK Represents HK to Draw Up Asian Pacific Treatment Guideline for Chronic Hepatitis B

Research
CUHK and French Researchers Pioneer the Use of Non-Invasive Imaging Technology – New XL Probe to Assess Liver Disease in Obese Patients

CUHK and French Researchers Pioneer the Use of Non-Invasive Imaging Technology – New XL Probe to Assess Liver Disease in Obese Patients

Research
CUHK Study Reveals High Salt Intake Will Lead to High Blood Pressure and Higher Risk of Stroke

CUHK Study Reveals High Salt Intake Will Lead to High Blood Pressure and Higher Risk of Stroke

Research
CUHK Launches Territory-wide Sleep Health Education Campaign to Promote Healthy Sleep and Healthy School Life

CUHK Launches Territory-wide Sleep Health Education Campaign to Promote Healthy Sleep and Healthy School Life

Health Campaign
CUHK and HKU's Collaborative Research Discovers Novel Epilepsy Genetic Markers

CUHK and HKU's Collaborative Research Discovers Novel Epilepsy Genetic Markers

Research
CUHK Advocates Early Detection of Chronic Kidney Diseases Joined by Leading Nephrologists to Make Sound Recommendations

CUHK Advocates Early Detection of Chronic Kidney Diseases Joined by Leading Nephrologists to Make Sound Recommendations

Research
CUHK Proves the Potent Efficacy of Stenting for Carotid Artery Narrowing and Cardiac Contractility Modulation for Heart Failure

CUHK Proves the Potent Efficacy of Stenting for Carotid Artery Narrowing and Cardiac Contractility Modulation for Heart Failure

Research
Three CUHK Scholars Named Croucher Senior Research Fellow 2011-12

Three CUHK Scholars Named Croucher Senior Research Fellow 2011-12

Awards and honors
CUHK Research Findings on Severe Human Swine Flu in Hong Kong

CUHK Research Findings on Severe Human Swine Flu in Hong Kong

Research

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