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https://www.med.cuhk.edu.hk/press-releases/40-of-hong-kong-people-show-gut-dysbiosis-comparable-to-that-of-covid-19-patients-cuhk-microbiome-immunity-formula-hastens-recovery-of-covid-19-patients-and-offers-hope-to-boost-immunity
https://www.med.cuhk.edu.hk/press-releases/40-of-hong-kong-people-show-gut-dysbiosis-comparable-to-that-of-covid-19-patients-cuhk-microbiome-immunity-formula-hastens-recovery-of-covid-19-patients-and-offers-hope-to-boost-immunity

40% of Hong Kong People Show Gut Dysbiosis Comparable to that of COVID-19 Patients CUHK Microbiome Immunity Formula Hastens Recovery of COVID-19 Patients and Offers Hope to Boost Immunity

Group photo

A recent CU Medicine study reveals that 40% of Hong Kong people appeared to have significant gut dysbiosis comparable to that of COVID-19 patients, suggesting they have potentially impaired immunity. The Faculty has developed a microbiome immunity formula that targets gut dysbiosis. Clinical evidence showed COVID-19 patients who received the formula recovered better than those had only standard care. Data also suggests the formula can restore the balance of gut microbiota and boosts immunity.  

 

From left: Dr. Joyce MAK, Assistant Professor of the Division of Gastroenterology and Hepatology at the Department of Medicine and Therapeutics; Professor Siew NG, Associate Director of the Centre for Gut Microbiota Research; and Professor Francis CHAN, Dean of Medicine and Director of the Centre for Gut Microbiota Research; CUHK.

Gut microbiota plays an important role in regulating immunity against infections. People who suffer from imbalance in gut microbiota (dysbiosis) are more susceptible to viral infection and other complications. An earlier study by the Faculty of Medicine of The Chinese University of Hong Kong (CU Medicine) has highlighted that severe gut dysbiosis exists in COVID-19 patients.

 

A recent study by CU Medicine revealed a worrying fact that 40% of Hong Kong people appeared to have significant gut dysbiosis comparable to that of COVID-19 patients, suggesting they have potentially impaired immunity. CU Medicine has developed a microbiome immunity formula that targets gut dysbiosis. Compared with patients who had standard care, our research team found that more COVID-19 patients who received the microbiome immunity formula achieved complete symptom resolution, showed significantly reduced proinflammatory markers in their blood,  had increased favourable bacteria in their stool; and developed neutralising antibody. Data also suggested that the formula can restore the balance of gut microbiota and boosts immunity.  

 

40% of people in HK have moderate to severe gut dysbiosis related to impaired immunity  

 

To evaluate the extent of dysbiosis in the general population, CU Medicine studied 1,000 subjects in Hong Kong aged between 18 and 83, and found that almost 40% of them had significant dysbiosis (i.e., impaired immunity) comparable to that of COVID-19 patients.

 

Professor Francis KL CHAN, Dean of Medicine and Director of the Centre for Gut Microbiota Research at CUHK remarked, “Gut dysbiosis is an important marker of impaired immunity. Our study findings showed 40% of Hong Kong people had evidence of significant dysbiosis comparable to that of COVID-19 patients which is alarming to us. We should take immediate action to restore the balance in gut microbiota and hence to help the public boost immunity against the threats of emerging infections such as COVID-19.”

 

CUHK’s microbiome immunity formula enhances recovery of COVID-19 patients

 

Dr. Joyce Mak

Dr Joyce Mak states that clinical studies have shown severe COVID-19 patients have achieved symptoms resolution, such as no more coughing, after taking the microbiome immunity formula developed by CU Medicine.

Using big data analysis and metagenomics derived from COVID-19 patients, researchers in CU Medicine has developed a unique oral microbiome formula that targets gut dysbiosis. Clinical data showed the recovery of COVID-19 patients who received the microbiome immunity formula outperformed those with standard care in many aspects.  These include the achievement of complete symptom resolution; significant reduction of proinflammatory markers in their blood, increase in favourable bacteria in their stool and development of neutralising antibody.
 
Amid the third wave of COVID-19 outbreak in Hong Kong, the CU Medicine team recruited 55 hospitalised patients with COVID-19; 25 patients were treated with the microbiome immunity formula and 30 received standard care. Key findings are as follow: 
  • 100% of patients treated with the microbiome immunity formula achieved complete resolution of symptoms compared with half in the control group by week 2.
  • 88% of patients in the microbiome immunity formula group developed neutralizing antibody compared with 63% in the control group.
  • The blood level of pro-inflammatory cytokines was significantly reduced in the microbiome immunity formula group, indicating that inflammation was under control.
  • The levels of favourable bacteria recovered from stool in patients receiving the microbiome immunity formula was significantly increased, suggesting that the formula could restore gut dysbiosis.
Prof. Siew Ng

 

 

“This study demonstrated that the microbiome immunity formula is effective in replenishing a series of good bacteria missing in the gut of COVID-19 patients. Restoration of gut dysbiosis could hasten symptom resolution, enhances host immunity and increases neutralising antibody. These data support the use of microbiome therapy as a potential strategy to restore gut dysbiosis to fight against COVID-19,” Professor Siew Chien NG, Associate Director of the Centre for Gut Microbiota Research at CUHK, explained.    

Prof. Francis Chan
 
 
Professor Francis KL CHAN concluded, “The imbalance of gut microbiota is common among Hong Kong people, indicating that many are suffering from impaired immunity. While there are many products in the market claiming that they could boost immunity, such claims need further scientific evidence. The development of this unique microbiome immunity formula was backed up by science and its benefits are supported by clinical evidence against COVID-19. The formula not only has the potential to hasten the recovery of COVID-19 patient, but also helps boost immunity of the public.”

 

 

 

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Clinical service
CUHK Discovers an Essential Oncogene in Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma

CUHK Discovers an Essential Oncogene in Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma

Research
CUHK Study Reveals Patients with Recovery of Hepatitis B Still at Risk of Liver Cancer

CUHK Study Reveals Patients with Recovery of Hepatitis B Still at Risk of Liver Cancer

Research
CUHK Launches World’s First Study Utilizing Retinal Imaging for Alzheimer’s Disease Screening in Chinese Population

CUHK Launches World’s First Study Utilizing Retinal Imaging for Alzheimer’s Disease Screening in Chinese Population

Research
CUHK Sees Atrial Fibrillation-related Stroke Cases 3 Times Higher Over 15 Years

CUHK Sees Atrial Fibrillation-related Stroke Cases 3 Times Higher Over 15 Years

Research
CUHK Proves Efficacy of Home-Based Management Approach of Obstructive Sleep Apnoea Applicable to 50% of Public Hospital Adult Cases with Waiting Time Reduced by 80%

CUHK Proves Efficacy of Home-Based Management Approach of Obstructive Sleep Apnoea Applicable to 50% of Public Hospital Adult Cases with Waiting Time Reduced by 80%

Research
CUHK Recommends Oral Glucose Tolerance Test for All Pregnant Women Study Reveals Children of Women with Gestational Diabetes Mellitus Have 3-Fold Diabetes Risk

CUHK Recommends Oral Glucose Tolerance Test for All Pregnant Women Study Reveals Children of Women with Gestational Diabetes Mellitus Have 3-Fold Diabetes Risk

Research
CUHK Reveals Non-Alcoholic Fatty Liver Disease Afflicts Even the Non-Obese

CUHK Reveals Non-Alcoholic Fatty Liver Disease Afflicts Even the Non-Obese

Research
CUHK World’s First Study Sets a New Direction on Aspirin Use after Lower Gastrointestinal Hemorrhage

CUHK World’s First Study Sets a New Direction on Aspirin Use after Lower Gastrointestinal Hemorrhage

Research
CUHK Professor Receives World Honour For Stroke Services Pioneering an Innovative 3-in-1 Multi-Target Therapy to Repair Damaged Brain After Stroke and Enhance Functional Recovery

CUHK Professor Receives World Honour For Stroke Services Pioneering an Innovative 3-in-1 Multi-Target Therapy to Repair Damaged Brain After Stroke and Enhance Functional Recovery

Awards and honors
CUHK Discovers Fatty Liver Causing Severe Liver Fibrosis or Cirrhosis in 1 Out of 5 Diabetic Patients

CUHK Discovers Fatty Liver Causing Severe Liver Fibrosis or Cirrhosis in 1 Out of 5 Diabetic Patients

Research
CUHK Opens Therese Pei Fong Chow Research Centre for Prevention of Dementia and Establishes a One-stop Online Platform to Provide Information on Dementia

CUHK Opens Therese Pei Fong Chow Research Centre for Prevention of Dementia and Establishes a One-stop Online Platform to Provide Information on Dementia

Research
CUHK Sets up the Global First Research Registry on Early Onset Dementia in Chinese Population

CUHK Sets up the Global First Research Registry on Early Onset Dementia in Chinese Population

Research
CUHK and HKU Researchers Introduce 3D Printing Technology in Complex Cardiac Surgery Procedures

CUHK and HKU Researchers Introduce 3D Printing Technology in Complex Cardiac Surgery Procedures

Research
CUHK Jointly Discovers New Therapeutic Solution for Minor Stroke in Global Study with over 30 Countries

CUHK Jointly Discovers New Therapeutic Solution for Minor Stroke in Global Study with over 30 Countries

Research
CUHK Sees Early Evaluation of TIA Patients Reduce Rate of Stroke by 70% in a Global Study of 21 Countries

CUHK Sees Early Evaluation of TIA Patients Reduce Rate of Stroke by 70% in a Global Study of 21 Countries

Research
CUHK Conducts Hong Kong’s First Study on Seven Common Respiratory Viruses Revealing Respiratory Syncytial Virus and Influenza A as Prevalent Fatal Types

CUHK Conducts Hong Kong’s First Study on Seven Common Respiratory Viruses Revealing Respiratory Syncytial Virus and Influenza A as Prevalent Fatal Types

Research
Asia’s First Research by CUHK on Patients’ Lifestyle Reveals Personalised Modification Programme Effective in Reducing Severity of OSA

Asia’s First Research by CUHK on Patients’ Lifestyle Reveals Personalised Modification Programme Effective in Reducing Severity of OSA

Research
CUHK Screening Reveals 1 in 3 Older Adults in Community Suffer Brain Small Vessel Disease, Early Prevention Recommended

CUHK Screening Reveals 1 in 3 Older Adults in Community Suffer Brain Small Vessel Disease, Early Prevention Recommended

Clinical service
CUHK Introduces High Frequency Oscillations to Determine Resection Margin Increases the Effectiveness of Complex Epilepsy Surgery by around 30%

CUHK Introduces High Frequency Oscillations to Determine Resection Margin Increases the Effectiveness of Complex Epilepsy Surgery by around 30%

Surgical advancement
CUHK Highlights the Significance of Hospital Infection Control System in Controlling MERS

CUHK Highlights the Significance of Hospital Infection Control System in Controlling MERS

Research
CUHK Advocates Stringent Control of Cardiovascular Risks for Reopening of Narrowed Brain Arteries - A New Paradigm to Prevent Recurrent Stroke (Available in Chinese only)

CUHK Advocates Stringent Control of Cardiovascular Risks for Reopening of Narrowed Brain Arteries - A New Paradigm to Prevent Recurrent Stroke (Available in Chinese only)

Research
CUHK Latest Research Reveals over 100,000 New Non-alcoholic Fatty Liver Cases in Hong Kong Annually

CUHK Latest Research Reveals over 100,000 New Non-alcoholic Fatty Liver Cases in Hong Kong Annually

Research
CUHK Study Reveals Peer Support Can Reduce Hospital Admission of Distressed Diabetes Patients

CUHK Study Reveals Peer Support Can Reduce Hospital Admission of Distressed Diabetes Patients

Research
Joint Study by CUHK and HKSH Reveals Patients with Comorbid REM Sleep Behavior Disorder and Depression may Suffer from Early-stage Neurodegeneration

Joint Study by CUHK and HKSH Reveals Patients with Comorbid REM Sleep Behavior Disorder and Depression may Suffer from Early-stage Neurodegeneration

Research
CUHK Advocates Atrial Fibrillation Screening and Drug Education to Reduce Risk of Stroke among Elderly

CUHK Advocates Atrial Fibrillation Screening and Drug Education to Reduce Risk of Stroke among Elderly

Clinical service
Screening Reveals Over 50% Community-dwelling Population Aged 65 or above are Pre-frail

Screening Reveals Over 50% Community-dwelling Population Aged 65 or above are Pre-frail

Research
Risk of Diabetes Patients Having Depression Doubles That of the General Public CUHK Advocates Timely Assessment of Diabetes Patients’ Mental Health Conditions

Risk of Diabetes Patients Having Depression Doubles That of the General Public CUHK Advocates Timely Assessment of Diabetes Patients’ Mental Health Conditions

Research
Radiotherapy to Head and Neck Raises Risk for Stroke CUHK Proved Effectiveness of Carotid Angioplasty and Stenting

Radiotherapy to Head and Neck Raises Risk for Stroke CUHK Proved Effectiveness of Carotid Angioplasty and Stenting

Research
CUHK and PolyU Jointly Introduce TeleStroke for 24-hour Thrombolysis Service at Prince of Wales Hospital

CUHK and PolyU Jointly Introduce TeleStroke for 24-hour Thrombolysis Service at Prince of Wales Hospital

Clinical service
CUHK Releases Research Results on Employment Status of Hong Kong Chronic Kidney Disease (CKD) Dialysis Patients and Promotes Predialysis Education Programme for Mid to Late Stage CKD patients

CUHK Releases Research Results on Employment Status of Hong Kong Chronic Kidney Disease (CKD) Dialysis Patients and Promotes Predialysis Education Programme for Mid to Late Stage CKD patients

Research
CUHK Announces Latest Medical Treatment for Minor Stroke

CUHK Announces Latest Medical Treatment for Minor Stroke

Research
CUHK-HCC Score Accurately Predicts Risk of Liver Cancer in Chronic Hepatitis B Patients Receiving Antiviral Therapy

CUHK-HCC Score Accurately Predicts Risk of Liver Cancer in Chronic Hepatitis B Patients Receiving Antiviral Therapy

Research
CUHK and Shanghai Jiao Tong University Discover Genetic Predictor of Diabetes in Chinese Patients

CUHK and Shanghai Jiao Tong University Discover Genetic Predictor of Diabetes in Chinese Patients

Research
CUHK Pioneers the Use of 3D Echocardiography to Identify At-Risk Mitral Valve Prolapse Patients

CUHK Pioneers the Use of 3D Echocardiography to Identify At-Risk Mitral Valve Prolapse Patients

Research
CUHK discovers that 40% of Individuals at Risk of Coronary Heart Disease have Pre-cancerous Bowel Tumors

CUHK discovers that 40% of Individuals at Risk of Coronary Heart Disease have Pre-cancerous Bowel Tumors

Research
CUHK Advocates Palliative Care for Advanced Dementia Patients with Swallowing Problems

CUHK Advocates Palliative Care for Advanced Dementia Patients with Swallowing Problems

Research
Bowel Cancer Will Become Top Cancer in Hong Kong CUHK Introduces Colon Pill Camera to Prevent Bowel Cancer

Bowel Cancer Will Become Top Cancer in Hong Kong CUHK Introduces Colon Pill Camera to Prevent Bowel Cancer

Surgical advancement
CUHK Study Reveals High Salt Intake Will Lead to High Blood Pressure and Higher Risk of Stroke

CUHK Study Reveals High Salt Intake Will Lead to High Blood Pressure and Higher Risk of Stroke

Research
CUHK Launches Territory-wide Sleep Health Education Campaign to Promote Healthy Sleep and Healthy School Life

CUHK Launches Territory-wide Sleep Health Education Campaign to Promote Healthy Sleep and Healthy School Life

Health Campaign
CUHK and HKU's Collaborative Research Discovers Novel Epilepsy Genetic Markers

CUHK and HKU's Collaborative Research Discovers Novel Epilepsy Genetic Markers

Research
CUHK Advocates Early Detection of Chronic Kidney Diseases Joined by Leading Nephrologists to Make Sound Recommendations

CUHK Advocates Early Detection of Chronic Kidney Diseases Joined by Leading Nephrologists to Make Sound Recommendations

Research
CUHK Discovers Up to 30% of Asymptomatic Subjects in Hong Kong Suffered from Pre-cancerous Bowel Tumors

CUHK Discovers Up to 30% of Asymptomatic Subjects in Hong Kong Suffered from Pre-cancerous Bowel Tumors

Research
CUHK Introduces Double Balloon Enteroscopy Service to Manage Small Bowel Diseases

CUHK Introduces Double Balloon Enteroscopy Service to Manage Small Bowel Diseases

Clinical service
CUHK Proves the Potent Efficacy of Stenting for Carotid Artery Narrowing and Cardiac Contractility Modulation for Heart Failure

CUHK Proves the Potent Efficacy of Stenting for Carotid Artery Narrowing and Cardiac Contractility Modulation for Heart Failure

Research
Three CUHK Scholars Named Croucher Senior Research Fellow 2011-12

Three CUHK Scholars Named Croucher Senior Research Fellow 2011-12

Awards and honors
Predicting Your Colorectal-polyp Risk with CUHK Colorectal-polyp Prediction Index (CU-CPI)

Predicting Your Colorectal-polyp Risk with CUHK Colorectal-polyp Prediction Index (CU-CPI)

Clinical service
CUHK Research Findings on Severe Human Swine Flu in Hong Kong

CUHK Research Findings on Severe Human Swine Flu in Hong Kong

Research

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