Search
What are you looking for?
Start main content

Press Releases

Press Releases

https://www.med.cuhk.edu.hk/press-releases/cu-medicine-finds-benign-prostatic-hyperplasia-patients-suffer-from-up-to-five-times-the-risk-of-urological-complications-after-covid-19-infection
https://www.med.cuhk.edu.hk/press-releases/cu-medicine-finds-benign-prostatic-hyperplasia-patients-suffer-from-up-to-five-times-the-risk-of-urological-complications-after-covid-19-infection

CU Medicine finds benign prostatic hyperplasia patients suffer from up to five times the risk of urological complications after COVID-19 infection

COVID-19 infection affects many extra-respiratory systems, including the urinary system. The Chinese University of Hong Kong (CUHK)’s Faculty of Medicine (CU Medicine) has conducted analysis using data from around 18,000 benign prostatic hyperplasia (BPH) patients in the local public healthcare system. Results showed that BPH patients infected with COVID-19 suffer from incidence rates of complications 2.9 to 5.31 times those of patients without COVID-19 infection, regardless of COVID-19 severity, among which the relative risk of urinary retention occurrence is the highest, followed by bacteriuria and haematuria. It is the largest cohort study in the world demonstrating that COVID-19 infection is associated with an increased incidence of BPH complications. Details of the study have been published in the Journal of Internal Medicine

 

BPH is a common health problem among middle-aged and older men

 

The prostate is a male sex gland which produces thick fluid that forms part of the semen. BPH is a non-malignant enlargement of the prostate gland, which may gradually progress to a compression of the urethral canal. This causes obstruction of the urethra and interferes with normal urine flow. An international literature shows that prevalence of BPH is more than 80% in males older than 70.

 

(From left) Dr Jeremy Teoh, Associate Professor, Division of Urology; Professor Ng Chi-fai, Tzu Leung Ho Professor of Urology, Department of Surgery at CU Medicine; and Dr Alex Liu, Resident, Division of Urology, Department of Surgery at the Prince of Wales Hospital.

 CU Medicine has conducted analysis using data from around 18,000 benign prostatic hyperplasia (BPH) patients in the local public healthcare system. Results showed that BPH patients infected with COVID-19 suffer from higher risk of complications than patients without COVID-19 infection, regardless of COVID-19 severity. Among the complications, the relative risk of urinary retention of the COVID-19 group is 5 times of that of the control subjects. (From left) Dr Jeremy Teoh, Associate Professor, Division of Urology; Professor Ng Chi-fai, Tzu Leung Ho Professor of Urology, Department of Surgery at CU Medicine; and Dr Alex Liu, Resident, Division of Urology, Department of Surgery at the Prince of Wales Hospital.

Professor Ng Chi-fai, Tzu Leung Ho Professor of Urology, Department of Surgery, CU Medicine, said, “BPH affects not only patients’ quality of life, but its complications such as retention of urine, urinary tract infection, haematuria and bladder stone formation can also cause patients’ clinical conditions to deteriorate. Acute hospital care is needed in severe cases. As prostate epithelial cells are known from previous studies to be a target of the COVID-19 virus, we hypothesised that the risk of BPH complications increases in people infected with the virus, and so we conducted this large-scale research.”

 

Largest cohort study in the world to demonstrate the association between COVID-19 infection and incidence of BPH complications

 

CU Medicine has conducted the largest cohort study in the world demonstrating COVID-19 infection’s association with the incidence of BPH complications. Its analysis examined data from all BPH patients receiving therapeutic treatment in Hospital Authority hospitals in 2021. 8,993 BPH patients with COVID-19 infection were included in the subject group (COVID-19 group), while the same number of BPH patients without COVID-19 infection were included in the control group. The two groups demonstrated statistically significant differences in incidence rates of complications, with the COVID-19 group showing a higher incidence of urinary retention, haematuria, and urinary tract infection. COVID-19 group also had a much higher incidence of the need for combination therapy, implied worsen of their symptom after the infection. Details can be found in table 1.

 

Table 1: Comparison of incidence rates of complications and clinical outcomes between BPH patients with and without COVID-19 infection

 

Incidence rate of complication and clinical outcomes

BPH patients with COVID-19 infection (COVID-19 group,

8,993 patients)

BPH patients without COVID-19 infection (control group,

8,993 patients)

Relative risk of complication in COVID-19 group compared with control group

Retention of urine

4.55%

0.86%

5.31

Haematuria

1.36%

0.41%

3.3

Urinary tract infection

4.31%

1.49%

2.9

Bacteriuria

9.02%

1.97%

4.58

Addition of combination therapy due to clinical condition deterioration

0.5%

0.02%

25

 

Dr Jeremy Teoh

Dr Jeremy Teoh says that there was a 70-year-old BPH patient had to be admitted to the hospital due to acute urinary retention after COVID-19 infection. He needed to cut the prostate tissue through surgery in order to resume normal urination.

Professor Ng Chi-fai

Professor Ng Chi-fai reminds patients with BPH that if they find symptoms such as difficulty in urinating, frequent urination, or lower abdominal distension and pain worsening after being infected with COVID-19, they should seek medical treatment as soon as possible.

Dr Alex Liu Qinyang, Resident, Division of Urology, Department of Surgery, Prince of Wales Hospital, stated, “It is worth noting that we found no differences in the incidence of urinary retention or haematuria across different COVID-19 severities. This suggests that even patients with asymptomatic or mild COVID-19 infection can still be affected urologically and suffer from BPH complications.”

 

Dr Alex Liu

Dr Alex Liu states that it is known from previous studies that prostate epidermal cells have two important proteins related to COVID-19 infection. Therefore, BPH patients are at an increased risk of urological complications after being infected with the virus.

Instead of COVID-19 severity, older age is correlated to a higher incidence of urological complications. For example, the study showed that the incidence rate of patients aged 90 or above in the COVID-19 group was 5.9%, while that of patients aged between 60 and 69 was 3.4%. Dr Jeremy Teoh Yuen-chun, Associate Professor, Division of Urology, Department of Surgery, CU Medicine, explained, “This study further shows that older BPH patients are more susceptible to the urological complications of COVID-19 than younger patients once infected. We believe that this is due to this benign condition displaying longitudinal progression with age, meaning patients present with enlarging prostate size and worsening symptoms.”

 

Dr Teoh added, “The higher risk of urological complications in BPH patients with COVID-19 infection represents a significant clinical burden that clinicians and urologists should be aware of.”

 

 

 

More Press Releases

CUHK Identifies Outcome Indicators for Benign Prostatic Hyperplasia Patients Receiving Prostatic Artery Embolisation

CUHK Identifies Outcome Indicators for Benign Prostatic Hyperplasia Patients Receiving Prostatic Artery Embolisation

Research
CU Medicine Survey Shows Global Urological Services have been Significantly Deferred due to COVID-19 Pandemic

CU Medicine Survey Shows Global Urological Services have been Significantly Deferred due to COVID-19 Pandemic

Research
CUHK study estimates half of COVID-19 infections went unrecognised during the Omicron epidemic in Hong Kong

CUHK study estimates half of COVID-19 infections went unrecognised during the Omicron epidemic in Hong Kong

Research
CU Medicine study published in The Lancet Infectious Diseases concludes that a novel oral microencapsulated live bacteria consortia (SIM01) alleviates long COVID symptoms

CU Medicine study published in The Lancet Infectious Diseases concludes that a novel oral microencapsulated live bacteria consortia (SIM01) alleviates long COVID symptoms

Research
CU Medicine discovers gut microbiome and metabolome markers that predict long-term COVID-19 vaccine effectiveness

CU Medicine discovers gut microbiome and metabolome markers that predict long-term COVID-19 vaccine effectiveness

Research
CUHK study reveals prevalence of myopia in children has reached record high in Hong Kong Number of myopic children aged six is double after COVID-19 restrictions Low-concentration atropine eyedrops with red light therapy study launched

CUHK study reveals prevalence of myopia in children has reached record high in Hong Kong Number of myopic children aged six is double after COVID-19 restrictions Low-concentration atropine eyedrops with red light therapy study launched

Research
CUHK-PWH research confirms Paxlovid can benefit patients with severe kidney disease

CUHK-PWH research confirms Paxlovid can benefit patients with severe kidney disease

Research
Joint Study Unveils How COVID-19  Adversely Impacts Placenta During Pregnancy

Joint Study Unveils How COVID-19 Adversely Impacts Placenta During Pregnancy

Research
T-cell responses elicited by COVID-19 vaccines Comirnaty and CoronaVac provide effective protection against severe disease from different SARS-CoV-2 variants

T-cell responses elicited by COVID-19 vaccines Comirnaty and CoronaVac provide effective protection against severe disease from different SARS-CoV-2 variants

Research
CU Medicine proves oral antivirals for COVID-19 can lower the risk of hospitalisation and  inpatient progression in older patients living in nursing homes

CU Medicine proves oral antivirals for COVID-19 can lower the risk of hospitalisation and inpatient progression in older patients living in nursing homes

Research
A randomised placebo-controlled clinical trial by CU Medicine shows that modulation of gut microbiome using oral microencapsulated live bacteria (SIM01) improves long COVID symptoms

A randomised placebo-controlled clinical trial by CU Medicine shows that modulation of gut microbiome using oral microencapsulated live bacteria (SIM01) improves long COVID symptoms

Research
CUHK finds high intention in Hong Kong to keep wearing masks and using alcohol-based sanitiser but low intention to receive a booster shot in the current era of COVID-19 endemicity

CUHK finds high intention in Hong Kong to keep wearing masks and using alcohol-based sanitiser but low intention to receive a booster shot in the current era of COVID-19 endemicity

Research
CU Medicine’s population-based long COVID-19 survey estimates that over 400,000 recovered COVID-19 patients suffer from sexual dysfunction and reproductive problems

CU Medicine’s population-based long COVID-19 survey estimates that over 400,000 recovered COVID-19 patients suffer from sexual dysfunction and reproductive problems

Research
A joint HKU-CUHK study confirms smoking and obesity increase  risk of severe COVID-19 by 65%-81%

A joint HKU-CUHK study confirms smoking and obesity increase risk of severe COVID-19 by 65%-81%

Research
Large-scale clinical study shows CU Medicine (SIM01) microbiome formula reduces risk of infections including COVID-19

Large-scale clinical study shows CU Medicine (SIM01) microbiome formula reduces risk of infections including COVID-19

Research
CUHK study advises residential care homes for the elderly to maintain current infection control practices

CUHK study advises residential care homes for the elderly to maintain current infection control practices

Research
CUHK-HKU collaborative study finds about 80% lower risk of death among COVID-19 inpatients prescribed oral medication and the risk of hospital admission in outpatients is significantly reduced by nearly 90%

CUHK-HKU collaborative study finds about 80% lower risk of death among COVID-19 inpatients prescribed oral medication and the risk of hospital admission in outpatients is significantly reduced by nearly 90%

Research
CUHK develops a real-time bioinformatics platform to predict COVID-19 vaccine effectiveness against SARS-CoV-2 variants with 95% accuracy

CUHK develops a real-time bioinformatics platform to predict COVID-19 vaccine effectiveness against SARS-CoV-2 variants with 95% accuracy

Research
CU Medicine supported by the Hospital Authority to launch HK’s first large-scale Long COVID survey, aiming to inform the government on impact of long COVID on healthcare services

CU Medicine supported by the Hospital Authority to launch HK’s first large-scale Long COVID survey, aiming to inform the government on impact of long COVID on healthcare services

Research
COVID-19 pandemic disrupted the daily lives of schoolchildren in Hong Kong; Proportion of overweight and obese kids more than doubled

COVID-19 pandemic disrupted the daily lives of schoolchildren in Hong Kong; Proportion of overweight and obese kids more than doubled

Research
CUHK finds that a booster vaccine dose is effective in retriggering antibodies in breast milk that protect babies

CUHK finds that a booster vaccine dose is effective in retriggering antibodies in breast milk that protect babies

Research
CUHK study suggests COVID-19 booster shot is key to protecting against infection among high-risk populations and from variants of concern

CUHK study suggests COVID-19 booster shot is key to protecting against infection among high-risk populations and from variants of concern

Research
HKUMed-CU Medicine joint study shows that vaccinated individuals develop more robust and broadly reactive antibody responses against SARS-CoV-2 variants than the unvaccinated after an Omicron infection

HKUMed-CU Medicine joint study shows that vaccinated individuals develop more robust and broadly reactive antibody responses against SARS-CoV-2 variants than the unvaccinated after an Omicron infection

Research
CUHK Clinical Trial Centre collaborates with CUHK Medical Centre to conduct Hong Kong’s first clinical trial of novel oral treatment specifically developed for COVID-19

CUHK Clinical Trial Centre collaborates with CUHK Medical Centre to conduct Hong Kong’s first clinical trial of novel oral treatment specifically developed for COVID-19

Research
CUHK researchers discover distinct gut microbial signatures for prediction, diagnosis and treatment of long COVID

CUHK researchers discover distinct gut microbial signatures for prediction, diagnosis and treatment of long COVID

Research
CU Medicine study shows a higher prevalence of dry eye disease  among post-COVID-19 patients

CU Medicine study shows a higher prevalence of dry eye disease among post-COVID-19 patients

Research
CU Medicine and Kowloon City District Office co-organise community COVID-19 vaccination programme targeting 2,000 residents, especially young children

CU Medicine and Kowloon City District Office co-organise community COVID-19 vaccination programme targeting 2,000 residents, especially young children

Health Campaign
A joint HKU-CUHK study finds that smoking  increases the risk of COVID-19

A joint HKU-CUHK study finds that smoking increases the risk of COVID-19

Research
CUHK-HKU collaborative research finds a new inflammatory activation pathway in  blood vessels after SARS-CoV-2 infection

CUHK-HKU collaborative research finds a new inflammatory activation pathway in blood vessels after SARS-CoV-2 infection

Research
CU Medicine study shows distinct gut microbial profile associated with long COVID

CU Medicine study shows distinct gut microbial profile associated with long COVID

Research
Assessment of Omicron outbreak in Hong Kong after reimplementation of some of the toughest social distancing measures effective from 7 January

Assessment of Omicron outbreak in Hong Kong after reimplementation of some of the toughest social distancing measures effective from 7 January

Research
HKUMed-CU Medicine joint study finds that third dose of Comirnaty has better protection from COVID-19 variant Omicron

HKUMed-CU Medicine joint study finds that third dose of Comirnaty has better protection from COVID-19 variant Omicron

Research
Study led by CUHK shows robotic-assisted bladder removal with intracorporeal urinary diversion reduces blood loss and enhances post-operative recovery

Study led by CUHK shows robotic-assisted bladder removal with intracorporeal urinary diversion reduces blood loss and enhances post-operative recovery

Research
HKUMed-CU Medicine joint study finds COVID-19 variant Omicron significantly reduces virus neutralisation ability of BioNTech vaccine

HKUMed-CU Medicine joint study finds COVID-19 variant Omicron significantly reduces virus neutralisation ability of BioNTech vaccine

Research
Joint CUHK-HKU study discovers efficacy of COVID-19 vaccines correlates with a probiotic bacterium, Bifidobacterium adolescentis

Joint CUHK-HKU study discovers efficacy of COVID-19 vaccines correlates with a probiotic bacterium, Bifidobacterium adolescentis

Research
CUHK study sheds light on novel mechanism and treatment of acute kidney injury in COVID-19 patients

CUHK study sheds light on novel mechanism and treatment of acute kidney injury in COVID-19 patients

Research
CUHK Study Suggests a Standardised Experimental Setup is the Key to Optimise  Performance of COVID-19 Nucleic Acid Tests

CUHK Study Suggests a Standardised Experimental Setup is the Key to Optimise Performance of COVID-19 Nucleic Acid Tests

Research
CUHK Study Demonstrates a 2.5-fold Increase in Myopia Incidence in Children  During COVID-19 Pandemic Due to Less Time Outdoors and More Time on Screens

CUHK Study Demonstrates a 2.5-fold Increase in Myopia Incidence in Children During COVID-19 Pandemic Due to Less Time Outdoors and More Time on Screens

Research
CU Medicine Survey Shows Only 25% of Unvaccinated People Intend to Get Inoculated in the Coming Six Months “Multiple Incentives” are Urgently Needed

CU Medicine Survey Shows Only 25% of Unvaccinated People Intend to Get Inoculated in the Coming Six Months “Multiple Incentives” are Urgently Needed

Research
CU Medicine Estimates 20,000 COVID-19 Hidden Infections in Hong Kong  All Vaccinated Persons in HK Developed Neutralising Antibody After Two Doses  Urgent Call for the Largely Unprotected Population to Get Vaccinated

CU Medicine Estimates 20,000 COVID-19 Hidden Infections in Hong Kong All Vaccinated Persons in HK Developed Neutralising Antibody After Two Doses Urgent Call for the Largely Unprotected Population to Get Vaccinated

Research
A Global Study Led by CU Medicine and HKUMed Discovers  a Hepatitis C Virus Drug as Potent Treatment for COVID-19

A Global Study Led by CU Medicine and HKUMed Discovers a Hepatitis C Virus Drug as Potent Treatment for COVID-19

Research
CU Medicine Study Shows Recovered Mothers Transfer COVID-19 Antibodies to Newborn Babies

CU Medicine Study Shows Recovered Mothers Transfer COVID-19 Antibodies to Newborn Babies

Research
CU Medicine Study Suggests Toddlers are at High Risk of Being  “Silent Spreaders of SARS-CoV2 Infection”

CU Medicine Study Suggests Toddlers are at High Risk of Being “Silent Spreaders of SARS-CoV2 Infection”

Research
CU Medicine Study Shows Modulation of Gut Microbiota  Helps Enhance Safety and Efficacy of COVID-19 Vaccine

CU Medicine Study Shows Modulation of Gut Microbiota Helps Enhance Safety and Efficacy of COVID-19 Vaccine

Research
CU Medicine and International Surgeons Suggest Patients with Positive COVID-19 Results Should Delay Surgery for Seven Weeks to Reduce Death Risk

CU Medicine and International Surgeons Suggest Patients with Positive COVID-19 Results Should Delay Surgery for Seven Weeks to Reduce Death Risk

International collaboration
CUHK and HKBU Launch Spermine Risk Score for Prostate Cancer Diagnosis

CUHK and HKBU Launch Spermine Risk Score for Prostate Cancer Diagnosis

Research
CU Medicine Finds New Evidence for Link between Gut Microbiome and COVID-19 Severity Microbiome Imbalance Might Influence “Long COVID” Risk

CU Medicine Finds New Evidence for Link between Gut Microbiome and COVID-19 Severity Microbiome Imbalance Might Influence “Long COVID” Risk

Research
CU Medicine Survey Shows Government Recommendation as the Strongest Driver for COVID-19 Vaccine Acceptance

CU Medicine Survey Shows Government Recommendation as the Strongest Driver for COVID-19 Vaccine Acceptance

Research
CUHK Introduces Nasal Strip Sampling for COVID-19 Test As a Superior Tool for Surveillance in a Wide Age-Range Population

CUHK Introduces Nasal Strip Sampling for COVID-19 Test As a Superior Tool for Surveillance in a Wide Age-Range Population

Research
40% of Hong Kong People Show Gut Dysbiosis Comparable to that of COVID-19 Patients CUHK Microbiome Immunity Formula Hastens Recovery of COVID-19 Patients and Offers Hope to Boost Immunity

40% of Hong Kong People Show Gut Dysbiosis Comparable to that of COVID-19 Patients CUHK Microbiome Immunity Formula Hastens Recovery of COVID-19 Patients and Offers Hope to Boost Immunity

Research
CUHK Study Shows Exposure Settings Impact COVID-19 Transmission With Entertainment Setting Showing Propensity for Widespread Dispersion

CUHK Study Shows Exposure Settings Impact COVID-19 Transmission With Entertainment Setting Showing Propensity for Widespread Dispersion

Research
CU Medicine Studies Highlight Smoking as a Contributing Factor for Bladder Cancer and  Develop an International Collaborative Consensus on En Bloc Resection to Treat the Disease

CU Medicine Studies Highlight Smoking as a Contributing Factor for Bladder Cancer and Develop an International Collaborative Consensus on En Bloc Resection to Treat the Disease

Research
CU Medicine Found SARS-CoV2 in Infants' Stool A Coronavirus Testing Centre Is Established for Paediatric Population to Identify Silent Carriers

CU Medicine Found SARS-CoV2 in Infants' Stool A Coronavirus Testing Centre Is Established for Paediatric Population to Identify Silent Carriers

Research
Most Deaths from COVID-19 in Hong Kong are of 60 Years Old or Above CUHK Initiated International Effort in Devising Strategies to Protect Older People with Dementia amid COVID-19 Pandemic

Most Deaths from COVID-19 in Hong Kong are of 60 Years Old or Above CUHK Initiated International Effort in Devising Strategies to Protect Older People with Dementia amid COVID-19 Pandemic

Research
CU Medicine Study Shows Liver Injury is Common and Prognostic in COVID-19 Patients

CU Medicine Study Shows Liver Injury is Common and Prognostic in COVID-19 Patients

Research
CUHK Researchers Uncover Diabetes as a Potential Risk Factor for COVID-19,  and Possible Mechanisms

CUHK Researchers Uncover Diabetes as a Potential Risk Factor for COVID-19, and Possible Mechanisms

Research
CU Medicine Develops a Probiotic Formula to Target Imbalance in Gut Microbiota in COVID-19

CU Medicine Develops a Probiotic Formula to Target Imbalance in Gut Microbiota in COVID-19

Research
CU Medicine Recruits 3,000 Persons to Investigate Hidden Infection and Break the Obstacles in Containing COVID-19 in Hong Kong

CU Medicine Recruits 3,000 Persons to Investigate Hidden Infection and Break the Obstacles in Containing COVID-19 in Hong Kong

Research
CU Medicine Offers Free Stool Screening Test for COVID-19 in Children arriving at Airport

CU Medicine Offers Free Stool Screening Test for COVID-19 in Children arriving at Airport

Clinical service
CUHK Finds that the Coronavirus Can Persist in Stool after Its Clearance in Respiratory Tract Will Conduct Stool Test for People in Quarantine Camps for Early Identification

CUHK Finds that the Coronavirus Can Persist in Stool after Its Clearance in Respiratory Tract Will Conduct Stool Test for People in Quarantine Camps for Early Identification

Research
CU Medicine Announces the Community Response Study Results During the Early Phase of the COVID-19 Outbreak in Hong Kong

CU Medicine Announces the Community Response Study Results During the Early Phase of the COVID-19 Outbreak in Hong Kong

Research
CUHK Successfully Conducted the World’s First Multi-Specialty Clinical Trial Using the Next Generation Single Port Robotic Surgical System

CUHK Successfully Conducted the World’s First Multi-Specialty Clinical Trial Using the Next Generation Single Port Robotic Surgical System

Surgical advancement
CUHK’s New Prostatic Artery Embolization Shows 90% Success Rate in Relieving Symptoms of Benign Prostatic Hyperplasia

CUHK’s New Prostatic Artery Embolization Shows 90% Success Rate in Relieving Symptoms of Benign Prostatic Hyperplasia

Clinical service
CUHK Opens S.H. Ho Urology Centre to Promote Earlier Diagnosis and Management of Prostate Cancer to the Territory

CUHK Opens S.H. Ho Urology Centre to Promote Earlier Diagnosis and Management of Prostate Cancer to the Territory

Clinical service
CUHK Assessed and Treated Over 300 Young Ketamine Abusers with Urinary Tract Dysfunction Latest Research Reveals Effectiveness of Integrated Anti-inflammatory Therapy

CUHK Assessed and Treated Over 300 Young Ketamine Abusers with Urinary Tract Dysfunction Latest Research Reveals Effectiveness of Integrated Anti-inflammatory Therapy

Research
CUHK Discovers Drug Dosage Brings Negative Impact on Bladder Function among Young People

CUHK Discovers Drug Dosage Brings Negative Impact on Bladder Function among Young People

Research

Our Expert List

Many experts under the Faculty of Medicine are available for media interview.
Please click here for the expert list or contact us.