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https://www.med.cuhk.edu.hk/press-releases/cuhk-announces-worlds-first-systematic-review-of-the-global-incidence-and-prevalence-of-inflammatory-bowel-diseases-in-the-21st-century-reveals-surge-in-hong-kong-in-past-30-years
https://www.med.cuhk.edu.hk/press-releases/cuhk-announces-worlds-first-systematic-review-of-the-global-incidence-and-prevalence-of-inflammatory-bowel-diseases-in-the-21st-century-reveals-surge-in-hong-kong-in-past-30-years

CUHK Announces World’s First Systematic Review of the Global Incidence and Prevalence of Inflammatory Bowel Diseases in the 21st Century Reveals Surge in Hong Kong in past 30 years

Researchers from The Chinese University of Hong Kong (CUHK) have conducted the world’s first systematic review of the global incidence and prevalence of Inflammatory Bowel Diseases (IBD) in the 21st century and found a continuous surge in the non-western world, with the incidence in Hong Kong having risen about 30 times in the past 30 years, much more seriously than in other Asia regions, such as Japan, Taiwan and Singapore. CUHK’s researchers regard this increase as alarming and think that IBD has emerged as a public health challenge worldwide. However, the continual surge also provides unique opportunities to identify the cause of IBD. Results of the systematic review have just been published in the leading medical journal The Lancet and presented yesterday in the World Congress of Gastroenterology in Orlando, USA.

 

IBD could lead to inflammation and ulceration of the gut which has emerged as a public health challenge worldwide

Crohn’s disease (CD) and ulcerative colitis (UC) are the two main subtypes of IBD which could lead to inflammation and ulceration of the gut. The onset of the disease frequently occurs in early life with the peak onset between 20 and 40 years of age, and with lifelong symptoms such as rectal bleeding, mucus in stool, abdominal pain, diarrhoea, weight loss, fever and extra-intestinal inflammation of other organs including the eyes, skin and joints. Treatment for IBD usually involves drug therapy, or in some severe cases, surgery.

 

IBD was traditionally regarded as a disease of Westernized nations. Over 1.5 million and 2 million people suffer from the disease in North America and Europe respectively and it imposes a heavy burden on the local healthcare systems. However, newer epidemiologic studies indicate that the incidence and prevalence are rising in Asia, South America, Eastern Europe and Africa, highlighting that IBD has emerged as a public health challenge worldwide.

 

CUHK together with Canadian experts have conducted the most updated and comprehensive systematic review to provide an insight into the global epidemiology of IBD

In order to provide insights into the epidemiology of IBD in the 21st century from a global perspective, researchers from CUHK, including Prof. Joseph SUNG, Vice-Chancellor and President of CUHK; Prof. Francis CHAN, Dean of the Faculty of Medicine; and Prof. Siew Chien NG, Professor of the Department of Medicine and Therapeutics, together with gastroenterologists and epidemiologists from the University of Calgary in Canada conducted a systematic review which is the most updated and comprehensive worldwide. The research team evaluated more than 11,000 studies on IBD, published from 1990 to 2016. Among them, 147 studies were identified for full-text review.

 

Results showed that there is a paradigm shift in the epidemiology of IBD in the 21st century. Since 1990, the incidence of IBD has stabilized in the Western world while other regions are showing a rising incidence as they have undergone Westernization, in terms of living style. In Hong Kong, there were 26 new IBD cases in a million people, which are higher than the figures in some other parts of Asia:

 

 IBD new cases (per million people)
South Korea78
Guangzhou33
Hong Kong26
Japan25
Macau24
Taiwan13
Singapore10
Bangkok6

 

Regarding the paradigm shift of IBD incidence observed in the study, Prof. Siew Chien NG, Professor of the Department of Medicine and Therapeutics, Faculty of Medicine at CUHK, stated, ‘The increase in incidence of IBD in regions other than the Western world is alarming. Taking Hong Kong as an example, the figure has increased about 30 times in the past 3 decades. Since the actual causes of IBD remain unknown and there is no cure at present, we believe the golden time to identify the cause or to prevent the disease is in the coming 10 years, before the incidence has peaked.’

 

Dr. Gilaad KAPLAN, Associate Professor, Cumming School of Medicine at the University of Calgary, added, ‘The high prevalence of IBD in the Western world will challenge clinicians to provide high quality and cost-efficient care to patients with IBD. More striking is the observation that as newly industrialized countries have transitioned towards a Westernized society, IBD emerges and its incidence rises rapidly. Consequently, we will need to prepare our clinical infrastructure and personnel to manage this complex and costly disease.’

 

CUHK team conducts cross-boundary and local research to identify risk factors of IBD

Prof. NG and her collaborators are also pursuing several researches to find out the risk factors of IBD. Apart from this very comprehensive and updated systematic review conducted with the University of Calgary, CUHK has just announced that Prof. NG’s team is also collaborating with research centres in Australia and mainland China on a research project entitled ‘The ENIGMA Studies - Eastern Inflammatory Bowel Disease (IBD) Gut Microbiota’ (ENIGMA). This project aims to study the association between IBD, especially Crohn's disease, and the patients’ gut microbiota and dietary habits.

 

The team is also studying mothers and infants with IBD in order to identify bacterial transmission pattern that may potentially lead to preventive measures for the disease. Members of the public can learn more about this project via https://www.cuhkibd.org/ or email to digestivehealth@cuhk.edu.hk.

 

The Faculty of Medicine at CUHK announces the world’s first systematic review of the global incidence and prevalence of Inflammatory Bowel Diseases (IBD) in the 21st century and found the incidence in Hong Kong having risen about 30 times in the past 30 years. Study results have just been published in the leading medical journal The Lancet. (From left) Prof. Siew NG and Chief Nursing Officer Ms Jessica CHING from the Department of Medicine and Therapeutics, Faculty of Medicine at CUHK, and the IBD patient Miss SUM.

The Faculty of Medicine at CUHK announces the world’s first systematic review of the global incidence and prevalence of Inflammatory Bowel Diseases (IBD) in the 21st century and found the incidence in Hong Kong having risen about 30 times in the past 30 years. Study results have just been published in the leading medical journal The Lancet. (From left) Prof. Siew NG and Chief Nursing Officer Ms Jessica CHING from the Department of Medicine and Therapeutics, Faculty of Medicine at CUHK, and the IBD patient Miss SUM.

Miss SUM was diagnosed with Crohn’s disease in 2016, a subtype of Inflammatory Bowel Diseases (IBD). She wishes studies of the gastroenterology team of the Faculty of Medicine at CUHK could figure out the cause of the disease and relieve IBD patients from the suffering.

Miss SUM was diagnosed with Crohn’s disease in 2016, a subtype of Inflammatory Bowel Diseases (IBD). She wishes studies of the gastroenterology team of the Faculty of Medicine at CUHK could figure out the cause of the disease and relieve IBD patients from the suffering.

Prof. Siew NG (left) states that Inflammatory Bowel Disease was traditionally regarded as a disease of Westernized nations, but newer epidemiologic studies indicate that the incidence is rising in Asia, highlighting that IBD has emerged as a global public health challenge.

Prof. Siew NG (left) states that Inflammatory Bowel Disease was traditionally regarded as a disease of Westernized nations, but newer epidemiologic studies indicate that the incidence is rising in Asia, highlighting that IBD has emerged as a global public health challenge.

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Radiotherapy to Head and Neck Raises Risk for Stroke CUHK Proved Effectiveness of Carotid Angioplasty and Stenting

Research
CUHK and PolyU Jointly Introduce TeleStroke for 24-hour Thrombolysis Service at Prince of Wales Hospital

CUHK and PolyU Jointly Introduce TeleStroke for 24-hour Thrombolysis Service at Prince of Wales Hospital

Clinical service
CUHK Releases Research Results on Employment Status of Hong Kong Chronic Kidney Disease (CKD) Dialysis Patients and Promotes Predialysis Education Programme for Mid to Late Stage CKD patients

CUHK Releases Research Results on Employment Status of Hong Kong Chronic Kidney Disease (CKD) Dialysis Patients and Promotes Predialysis Education Programme for Mid to Late Stage CKD patients

Research
CUHK Announces Latest Medical Treatment for Minor Stroke

CUHK Announces Latest Medical Treatment for Minor Stroke

Research
CUHK-HCC Score Accurately Predicts Risk of Liver Cancer in Chronic Hepatitis B Patients Receiving Antiviral Therapy

CUHK-HCC Score Accurately Predicts Risk of Liver Cancer in Chronic Hepatitis B Patients Receiving Antiviral Therapy

Research
CUHK Received Four Ministry of Education Higher Education Outstanding Scientific Research Output Awards The Highest Share among Hong Kong Institutions

CUHK Received Four Ministry of Education Higher Education Outstanding Scientific Research Output Awards The Highest Share among Hong Kong Institutions

Awards and honors
CUHK and Shanghai Jiao Tong University Discover Genetic Predictor of Diabetes in Chinese Patients

CUHK and Shanghai Jiao Tong University Discover Genetic Predictor of Diabetes in Chinese Patients

Research
CUHK Pioneers the Use of 3D Echocardiography to Identify At-Risk Mitral Valve Prolapse Patients

CUHK Pioneers the Use of 3D Echocardiography to Identify At-Risk Mitral Valve Prolapse Patients

Research
CUHK discovers that 40% of Individuals at Risk of Coronary Heart Disease have Pre-cancerous Bowel Tumors

CUHK discovers that 40% of Individuals at Risk of Coronary Heart Disease have Pre-cancerous Bowel Tumors

Research
CUHK will hold 'SARS A Decade On: A Conference for the Health Professionals'

CUHK will hold 'SARS A Decade On: A Conference for the Health Professionals'

Symposium
CUHK Advocates Palliative Care for Advanced Dementia Patients with Swallowing Problems

CUHK Advocates Palliative Care for Advanced Dementia Patients with Swallowing Problems

Research
CUHK Study Reveals High Salt Intake Will Lead to High Blood Pressure and Higher Risk of Stroke

CUHK Study Reveals High Salt Intake Will Lead to High Blood Pressure and Higher Risk of Stroke

Research
CUHK Launches Territory-wide Sleep Health Education Campaign to Promote Healthy Sleep and Healthy School Life

CUHK Launches Territory-wide Sleep Health Education Campaign to Promote Healthy Sleep and Healthy School Life

Health Campaign
CUHK and HKU's Collaborative Research Discovers Novel Epilepsy Genetic Markers

CUHK and HKU's Collaborative Research Discovers Novel Epilepsy Genetic Markers

Research
CUHK Advocates Early Detection of Chronic Kidney Diseases Joined by Leading Nephrologists to Make Sound Recommendations

CUHK Advocates Early Detection of Chronic Kidney Diseases Joined by Leading Nephrologists to Make Sound Recommendations

Research
Why is Liver Cancer More Prevalent in Men than in Women? CUHK Discovers a Sex Hormone-controlled Gene that Promotes Liver Cancer

Why is Liver Cancer More Prevalent in Men than in Women? CUHK Discovers a Sex Hormone-controlled Gene that Promotes Liver Cancer

Research
CUHK Introduces Double Balloon Enteroscopy Service to Manage Small Bowel Diseases

CUHK Introduces Double Balloon Enteroscopy Service to Manage Small Bowel Diseases

Clinical service
CUHK Proves the Potent Efficacy of Stenting for Carotid Artery Narrowing and Cardiac Contractility Modulation for Heart Failure

CUHK Proves the Potent Efficacy of Stenting for Carotid Artery Narrowing and Cardiac Contractility Modulation for Heart Failure

Research
Three CUHK Scholars Named Croucher Senior Research Fellow 2011-12

Three CUHK Scholars Named Croucher Senior Research Fellow 2011-12

Awards and honors
Predicting Your Colorectal-polyp Risk with CUHK Colorectal-polyp Prediction Index (CU-CPI)

Predicting Your Colorectal-polyp Risk with CUHK Colorectal-polyp Prediction Index (CU-CPI)

Clinical service
CUHK Research Findings on Severe Human Swine Flu in Hong Kong

CUHK Research Findings on Severe Human Swine Flu in Hong Kong

Research

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