Search
What are you looking for?
Start main content

Press Releases

Press Releases

https://www.med.cuhk.edu.hk/press-releases/cuhk-succeeded-in-animal-study-and-clinical-case-of-percutaneous-nanoknife-new-breakthrough-in-cancer-treatment
https://www.med.cuhk.edu.hk/press-releases/cuhk-succeeded-in-animal-study-and-clinical-case-of-percutaneous-nanoknife-new-breakthrough-in-cancer-treatment

CUHK Succeeded in Animal Study and Clinical Case of Percutaneous Nanoknife New Breakthrough in Cancer Treatment

Prof. Simon Yu, Director of Vascular and Interventional Radiology Foundation Clinical Science Center and Professor of Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong (CUHK) successfully completed a clinical case of percutaneous Nanoknife (Irreversible Electroporation) treatment on a liver cancer patient.  The advantage of the treatment over thermal ablation techniques such as microwave or radiofrequency ablation is that it does not damage the blood vessels, bile ducts, or nerves near the tumors.  It can be used to treat cancers in the liver, lung, prostate, head and neck, kidney, and pancreas without surgical operation. 

 

Prof. Simon Yu, Director of Vascular and Interventional Radiology Foundation Clinical Science Center and Professor of Department of Imaging and Interventional Radiology, CUHK successfully conducted the animal study and clinical case of percutaneous Nanoknife.

Prof. Simon Yu, Director of Vascular and Interventional Radiology Foundation Clinical Science Center and Professor of Department of Imaging and Interventional Radiology, CUHK successfully conducted the animal study and clinical case of percutaneous Nanoknife.

Thermal ablation such as microwave ablation and radiofrequency ablation are widely accepted as effective treatments for liver cancer, with a clinical outcome comparable to that of surgical resection for liver tumor of size below 5cm.  However, thermal ablation could not effectively eradicate cancer cells that are close to blood vessels due to the 'heat-sink' effect which prevents the building up of a tumoricidal temperature.  As a result, recurrence of tumor in these areas tends to occur.  Thermal ablation also causes thermal damage to bile ducts, gallbladder, and bowel, leading to bile duct occlusion, and perforation of gall bladder and the bowel.  Nanoknife is a new technological breakthrough in cancer treatment, applicable to solid tumors of size less than 5cm and to tumors that are close to blood vessels, nerves and bile ducts. 

 

Under the sponsorship of the Vascular and Interventional Radiology Foundation, Prof. Simon Yu and his research team successfully conducted an animal study on percutaneous Nanoknife between March and June of 2013.  The objective of the animal study was to discover the short, middle and long term effect of Nanoknife on various organs of live pigs.  It was revealed that Nanoknife is effective in causing apoptosis in the cells of lung, kidney and muscle; it does not cause damage to blood vessels, nerves, bile ducts, and bones; and it is not harmful to the stomach and urinary bladder when a safe distance is kept. 

 

Building upon the favourable findings in the animal study, Professor Yu conducted a clinical study of percutaneous Nanoknife treatment on patients with liver tumor or pancreatic tumor of size less than 3cm.  In November 2013, a clinical case of percutaneous Nanoknife treatment was successfully completed on a liver cancer patient.  The patient was put under general anaesthesia using neuromuscular blockade to avoid skeletal muscle contraction.  Under the guidance of ultrasound and CT, needle-like electrodes of 1mm diameter penetrated the skin to reach the tumor.  Ultra-short but strong electric current was emitted by the electrodes in a controlled fashion to kill the tumor cells.  The size and location of the electric field are calculated and mapped out electronically to ensure complete coverage of the tumor.  The tumor cells are subsequently absorbed and replaced by normal healthy cells via the body's natural healing process. 

 

Prof. Simon Yu remarked, 'Thanks to the generous support of the Vascular and Interventional Radiology Foundation, we completed the animal study in June 2013 and conducted the percutaneousNanoknife treatment in November 2013.  The treatment lasted for just an hour and left only wounds of the size of needle holes on the patient's skin.  The patient could be discharged on the next day after treatment.  We shall continue our clinical trial and hope to introduce this new and effective treatment in local hospitals very soon.'  

 

Prof. Simon Yu, Director of Vascular and Interventional Radiology Foundation Clinical Science Center and Professor of Department of Imaging and Interventional Radiology, CUHK successfully conducted the animal study and clinical case of percutaneous Nanoknife.

More Press Releases

CUHK Study Proves Ablative Chemoembolization Doubles the Progression-Free Survival for Liver Cancer Patients

CUHK Study Proves Ablative Chemoembolization Doubles the Progression-Free Survival for Liver Cancer Patients

Research
CUHK Proves Modified HIFU Treatment Effective for Treating Uterine Fibroids

CUHK Proves Modified HIFU Treatment Effective for Treating Uterine Fibroids

Research
CUHK Proves Prostate Artery Embolization Effective for Benign Prostatic Hyperplasia

CUHK Proves Prostate Artery Embolization Effective for Benign Prostatic Hyperplasia

Research
CUHK Sets up the Global First Research Registry on Early Onset Dementia in Chinese Population

CUHK Sets up the Global First Research Registry on Early Onset Dementia in Chinese Population

Research
CUHK’s New Prostatic Artery Embolization Shows 90% Success Rate in Relieving Symptoms of Benign Prostatic Hyperplasia

CUHK’s New Prostatic Artery Embolization Shows 90% Success Rate in Relieving Symptoms of Benign Prostatic Hyperplasia

Clinical service
CUHK Discovers Innovative ‘Flow Diverters’ (Pipeline) as Effective Treatment for Cerebral Aneurysms in Asia’s First Clinical Study in Collaboration with Seven Medical Centres

CUHK Discovers Innovative ‘Flow Diverters’ (Pipeline) as Effective Treatment for Cerebral Aneurysms in Asia’s First Clinical Study in Collaboration with Seven Medical Centres

Research
CUHK Successfully Performed World’s First Colorectal Endoscopic Submucosal Dissection  Using Flexible Endoscopic Robotic System

CUHK Successfully Performed World’s First Colorectal Endoscopic Submucosal Dissection Using Flexible Endoscopic Robotic System

Surgical advancement
CUHK Pioneers Whole Genome Sequencing for Identifying the Chromosomal Abnormalities in Couples with Recurrent Miscarriages

CUHK Pioneers Whole Genome Sequencing for Identifying the Chromosomal Abnormalities in Couples with Recurrent Miscarriages

Research
Insights into B-cells and GPR18 Gene Expression by CU Medicine team  Improve Prediction of Survival in Multiple Cancer Types

Insights into B-cells and GPR18 Gene Expression by CU Medicine team Improve Prediction of Survival in Multiple Cancer Types

Research
CU Medicine Team Discovers a Novel Prognostic Biomarker for a Doubled Survival in Head and Neck Cancer

CU Medicine Team Discovers a Novel Prognostic Biomarker for a Doubled Survival in Head and Neck Cancer

Research
CUHK in collaboration with West China School of Medicine co-Led World’s First-in-human Clinical Trial using CRISPR technology for lung cancer Confirmed gene-edited T-Cell Therapy is Safe and Feasible in Treatment of Advanced NSCLC

CUHK in collaboration with West China School of Medicine co-Led World’s First-in-human Clinical Trial using CRISPR technology for lung cancer Confirmed gene-edited T-Cell Therapy is Safe and Feasible in Treatment of Advanced NSCLC

Research
CU Medicine Announces the Community Response Study Results During the Early Phase of the COVID-19 Outbreak in Hong Kong

CU Medicine Announces the Community Response Study Results During the Early Phase of the COVID-19 Outbreak in Hong Kong

Research
The Helmsley Charitable Trust Funds Asian Research into Babies’ Gut Microbiota and Crohn’s Disease

The Helmsley Charitable Trust Funds Asian Research into Babies’ Gut Microbiota and Crohn’s Disease

Research
CUHK Study Sees the Exposure to Farm Environment  Is Beneficial for Children to Prevent Asthma

CUHK Study Sees the Exposure to Farm Environment Is Beneficial for Children to Prevent Asthma

Research
Chinese Women with Polycystic Ovarian Syndrome have 4-fold Higher Risk of Developing Diabetes

Chinese Women with Polycystic Ovarian Syndrome have 4-fold Higher Risk of Developing Diabetes

Research
Multicomponent Frailty Prevention Programme Reduces Frailty Over 80% of Pre-frail Elderly Reverse to Robust Phenotype

Multicomponent Frailty Prevention Programme Reduces Frailty Over 80% of Pre-frail Elderly Reverse to Robust Phenotype

Research
CUHK Validates the Enhanced UK Fetal Medicine Foundation’s Triple Test Can Double the Detection Rate of Preterm Preeclampsia in Asian Pregnant Women

CUHK Validates the Enhanced UK Fetal Medicine Foundation’s Triple Test Can Double the Detection Rate of Preterm Preeclampsia in Asian Pregnant Women

Research
CUHK Pioneers Whole Genome Sequencing for Prenatal Diagnosis in Hong Kong

CUHK Pioneers Whole Genome Sequencing for Prenatal Diagnosis in Hong Kong

Research
CUHK to Commence the Next-Generation Clinical Trials of CAR-T Cell Therapy for Haematological Malignancy

CUHK to Commence the Next-Generation Clinical Trials of CAR-T Cell Therapy for Haematological Malignancy

Research
CUHK Successfully Conducts Asia-Pacific’s First Hybrid Operating Room Non-invasive Bronchoscopic Microwave Ablation to Treat Lung Cancer

CUHK Successfully Conducts Asia-Pacific’s First Hybrid Operating Room Non-invasive Bronchoscopic Microwave Ablation to Treat Lung Cancer

Surgical advancement
李嘉誠基金會啟動《愛能助》兒童癌症項目 資助兒童罕見癌症 (Chinese version only)

李嘉誠基金會啟動《愛能助》兒童癌症項目 資助兒童罕見癌症 (Chinese version only)

Donation
Professor Tony MOK Honoured with the ESMO Lifetime Achievement Award Recognising His Global Leadership in Defining Lung Cancer Treatment Standard

Professor Tony MOK Honoured with the ESMO Lifetime Achievement Award Recognising His Global Leadership in Defining Lung Cancer Treatment Standard

Awards and honors
CUHK Receives an International Cancer Care Team Award Nominated by Patients

CUHK Receives an International Cancer Care Team Award Nominated by Patients

Awards and honors
CUHK Launches Multi-Cancer Prevention Programme Providing Free Screening to 10,000 HK Residents to Study Links with Obesity

CUHK Launches Multi-Cancer Prevention Programme Providing Free Screening to 10,000 HK Residents to Study Links with Obesity

Health Campaign
CUHK-led Global Study Sees Improvement in Overall Survival in Patients with Advanced Lung Cancer

CUHK-led Global Study Sees Improvement in Overall Survival in Patients with Advanced Lung Cancer

Research
CUHK Study Sees Increasing Global Incidence of Colorectal Cancer Among Younger People

CUHK Study Sees Increasing Global Incidence of Colorectal Cancer Among Younger People

Research
CUHK Pioneers Early Lung Cancer Treatment with Hybrid Operating Room Image Guided Electromagnetic Navigation Bronchoscopy

CUHK Pioneers Early Lung Cancer Treatment with Hybrid Operating Room Image Guided Electromagnetic Navigation Bronchoscopy

Surgical advancement
A CUHK-led International Study Demonstrates Immune-checkpoint Inhibitor Is Effective in Patients with Advanced Nasopharyngeal Cancer

A CUHK-led International Study Demonstrates Immune-checkpoint Inhibitor Is Effective in Patients with Advanced Nasopharyngeal Cancer

Research
CUHK Research Receives Recognitions by Top Medical Journals

CUHK Research Receives Recognitions by Top Medical Journals

Awards and honors
CUHK-HKU Study on Multi-gene Mutation-Drug Matching for Recurrent Ovarian Cancer Patients Providing Free Pharmacogenomic Analysis for 100 Patients in Hong Kong

CUHK-HKU Study on Multi-gene Mutation-Drug Matching for Recurrent Ovarian Cancer Patients Providing Free Pharmacogenomic Analysis for 100 Patients in Hong Kong

Research
CUHK Completes a 20,000-person Plasma DNA Screening Study of Nasopharyngeal Cancer, and Finds a Dramatic Shift to Early Stage Cancers

CUHK Completes a 20,000-person Plasma DNA Screening Study of Nasopharyngeal Cancer, and Finds a Dramatic Shift to Early Stage Cancers

Research
CUHK-led Research Confirms Novel Targeted Therapy Doubles the Effectiveness of Current Standard Treatment for ALK-Positive Lung Cancer

CUHK-led Research Confirms Novel Targeted Therapy Doubles the Effectiveness of Current Standard Treatment for ALK-Positive Lung Cancer

Research
CUHK Uncovers Novel Immune Escape Mechanism of Cancer Opening Up New Direction for Cancer Immunotherapy

CUHK Uncovers Novel Immune Escape Mechanism of Cancer Opening Up New Direction for Cancer Immunotherapy

Research
CUHK Unravels the Whole Genome of Nasopharyngeal Cancer A Great Leap Forward in Personalized Medicine Development

CUHK Unravels the Whole Genome of Nasopharyngeal Cancer A Great Leap Forward in Personalized Medicine Development

Research
CUHK Leads a Multinational Study that Finds New Treatment Paradigm of Mutated Lung Cancer

CUHK Leads a Multinational Study that Finds New Treatment Paradigm of Mutated Lung Cancer

Research
CUHK-led Study Reveals Novel Mechanism for the Development of Atherosclerosis Setting New Treatment Directions to Cardiovascular Diseases

CUHK-led Study Reveals Novel Mechanism for the Development of Atherosclerosis Setting New Treatment Directions to Cardiovascular Diseases

Research
CUHK Launches World’s First Study on Ovum Ageing and Female Infertility by Using Single-Cell Genomics Technology

CUHK Launches World’s First Study on Ovum Ageing and Female Infertility by Using Single-Cell Genomics Technology

Research
CUHK World’s First Study Sets a New Direction on Aspirin Use after Lower Gastrointestinal Hemorrhage

CUHK World’s First Study Sets a New Direction on Aspirin Use after Lower Gastrointestinal Hemorrhage

Research
CUHK Discovers Fatty Liver Causing Severe Liver Fibrosis or Cirrhosis in 1 Out of 5 Diabetic Patients

CUHK Discovers Fatty Liver Causing Severe Liver Fibrosis or Cirrhosis in 1 Out of 5 Diabetic Patients

Research
CUHK Opens Therese Pei Fong Chow Research Centre for Prevention of Dementia and Establishes a One-stop Online Platform to Provide Information on Dementia

CUHK Opens Therese Pei Fong Chow Research Centre for Prevention of Dementia and Establishes a One-stop Online Platform to Provide Information on Dementia

Research
CUHK World’s First Study Confirms A New Colorectal Cancer High Risk Group

CUHK World’s First Study Confirms A New Colorectal Cancer High Risk Group

Research
CUHK Asia’s First Comprehensive Epidemiological Study on Health Impact of Household Cleaning Products on Children Reveals Frequent Use of Household Cleaning Products Increase Risk of Triggering Rhinitis in Children

CUHK Asia’s First Comprehensive Epidemiological Study on Health Impact of Household Cleaning Products on Children Reveals Frequent Use of Household Cleaning Products Increase Risk of Triggering Rhinitis in Children

Research
CUHK and HKU Researchers Introduce 3D Printing Technology in Complex Cardiac Surgery Procedures

CUHK and HKU Researchers Introduce 3D Printing Technology in Complex Cardiac Surgery Procedures

Research
CUHK Jointly Discovers New Therapeutic Solution for Minor Stroke in Global Study with over 30 Countries

CUHK Jointly Discovers New Therapeutic Solution for Minor Stroke in Global Study with over 30 Countries

Research
CUHK Sees Early Evaluation of TIA Patients Reduce Rate of Stroke by 70% in a Global Study of 21 Countries

CUHK Sees Early Evaluation of TIA Patients Reduce Rate of Stroke by 70% in a Global Study of 21 Countries

Research
CUHK Research Shows 1 in 5 Throat Cancer Patients in HK is HPV infected

CUHK Research Shows 1 in 5 Throat Cancer Patients in HK is HPV infected

Research
CUHK Conducts Hong Kong’s First Study on Seven Common Respiratory Viruses Revealing Respiratory Syncytial Virus and Influenza A as Prevalent Fatal Types

CUHK Conducts Hong Kong’s First Study on Seven Common Respiratory Viruses Revealing Respiratory Syncytial Virus and Influenza A as Prevalent Fatal Types

Research
CUHK/International Study Implicates a Gene in Alzheimer’s disease

CUHK/International Study Implicates a Gene in Alzheimer’s disease

Research
CUHK Launches Hong Kong’s First Pilot Integrative Medicine Programme in Multiple Sclerosis for Managing Cognitive Symptoms, Relieving Fatigue, and Disease Control

CUHK Launches Hong Kong’s First Pilot Integrative Medicine Programme in Multiple Sclerosis for Managing Cognitive Symptoms, Relieving Fatigue, and Disease Control

Research
Asia’s First Research by CUHK on Patients’ Lifestyle Reveals Personalised Modification Programme Effective in Reducing Severity of OSA

Asia’s First Research by CUHK on Patients’ Lifestyle Reveals Personalised Modification Programme Effective in Reducing Severity of OSA

Research
CUHK Screening Reveals 1 in 3 Older Adults in Community Suffer Brain Small Vessel Disease, Early Prevention Recommended

CUHK Screening Reveals 1 in 3 Older Adults in Community Suffer Brain Small Vessel Disease, Early Prevention Recommended

Clinical service
CUHK Latest Research Reveals FMT Effectiveness Triples that of Conventional Treatment

CUHK Latest Research Reveals FMT Effectiveness Triples that of Conventional Treatment

Research
CUHK Introduces New Material for Osteoporosis-related Bone Fracture Effectively Reduces Healing Time and Enhances Bone Strength Both by 30%

CUHK Introduces New Material for Osteoporosis-related Bone Fracture Effectively Reduces Healing Time and Enhances Bone Strength Both by 30%

Research
CUHK and PWH Introduce Leading 3D Imaging System which Reduces Radiation Dosage by 90%

CUHK and PWH Introduce Leading 3D Imaging System which Reduces Radiation Dosage by 90%

Clinical service
CUHK Highlights the Significance of Hospital Infection Control System in Controlling MERS

CUHK Highlights the Significance of Hospital Infection Control System in Controlling MERS

Research
CUHK Estimates Local Smokers Spend over HKD1 Million on Tobacco in Life

CUHK Estimates Local Smokers Spend over HKD1 Million on Tobacco in Life

Research
CUHK Advocates Stringent Control of Cardiovascular Risks for Reopening of Narrowed Brain Arteries - A New Paradigm to Prevent Recurrent Stroke (Available in Chinese only)

CUHK Advocates Stringent Control of Cardiovascular Risks for Reopening of Narrowed Brain Arteries - A New Paradigm to Prevent Recurrent Stroke (Available in Chinese only)

Research
CUHK Latest Research Reveals over 100,000 New Non-alcoholic Fatty Liver Cases in Hong Kong Annually

CUHK Latest Research Reveals over 100,000 New Non-alcoholic Fatty Liver Cases in Hong Kong Annually

Research
CUHK Reveals Hepatitis B Prevalence Among Pregnant Women Remains High Despite More Than 25 Years of Universal Hepatitis B Vaccination

CUHK Reveals Hepatitis B Prevalence Among Pregnant Women Remains High Despite More Than 25 Years of Universal Hepatitis B Vaccination

Research
CUHK Research by Medical Undergraduates Reveals Poor Medication Adherence Among Hypertensive Patients in Hong Kong

CUHK Research by Medical Undergraduates Reveals Poor Medication Adherence Among Hypertensive Patients in Hong Kong

Research
CUHK Study Reveals Peer Support Can Reduce Hospital Admission of Distressed Diabetes Patients

CUHK Study Reveals Peer Support Can Reduce Hospital Admission of Distressed Diabetes Patients

Research
Joint Study by CUHK and HKSH Reveals Patients with Comorbid REM Sleep Behavior Disorder and Depression may Suffer from Early-stage Neurodegeneration

Joint Study by CUHK and HKSH Reveals Patients with Comorbid REM Sleep Behavior Disorder and Depression may Suffer from Early-stage Neurodegeneration

Research
Screening Reveals Over 50% Community-dwelling Population Aged 65 or above are Pre-frail

Screening Reveals Over 50% Community-dwelling Population Aged 65 or above are Pre-frail

Research
CUHK Opens Phase I Clinical Trial Centre To Step Up New Drug Development in Hong Kong

CUHK Opens Phase I Clinical Trial Centre To Step Up New Drug Development in Hong Kong

Research
CUHK Survey Reveals Relationship between Exercise Pattern and Emotional Health among Hong Kong People Mind-body Exercise Helps Reduce Risk of Mood Disorders

CUHK Survey Reveals Relationship between Exercise Pattern and Emotional Health among Hong Kong People Mind-body Exercise Helps Reduce Risk of Mood Disorders

Research
CUHK Establishes State Key Laboratory of Digestive Disease to Improve Diagnosis and Treatment of Digestive Diseases

CUHK Establishes State Key Laboratory of Digestive Disease to Improve Diagnosis and Treatment of Digestive Diseases

Research
CUHK Releases Research Results on Employment Status of Hong Kong Chronic Kidney Disease (CKD) Dialysis Patients and Promotes Predialysis Education Programme for Mid to Late Stage CKD patients

CUHK Releases Research Results on Employment Status of Hong Kong Chronic Kidney Disease (CKD) Dialysis Patients and Promotes Predialysis Education Programme for Mid to Late Stage CKD patients

Research
CUHK Conducts Asia's Largest Clinical Study on Life-threatening Infections caused by RSV and Influenza in Hong Kong Adults and Elderly

CUHK Conducts Asia's Largest Clinical Study on Life-threatening Infections caused by RSV and Influenza in Hong Kong Adults and Elderly

Research
CUHK Announces Latest Medical Treatment for Minor Stroke

CUHK Announces Latest Medical Treatment for Minor Stroke

Research
Hong Kong and Macau Among Top Three Regions in Asia-Pacific with the Highest Incidence of Inflammatory Bowel Disease CUHK Establishes Registry to Increase Public Awareness

Hong Kong and Macau Among Top Three Regions in Asia-Pacific with the Highest Incidence of Inflammatory Bowel Disease CUHK Establishes Registry to Increase Public Awareness

Research
CUHK Assessed and Treated Over 300 Young Ketamine Abusers with Urinary Tract Dysfunction Latest Research Reveals Effectiveness of Integrated Anti-inflammatory Therapy

CUHK Assessed and Treated Over 300 Young Ketamine Abusers with Urinary Tract Dysfunction Latest Research Reveals Effectiveness of Integrated Anti-inflammatory Therapy

Research
CUHK Research Reveals that Physical and Cognitive Activities can Maintain and Improve Brain Functions of Patients with Mild Cognitive Impairments

CUHK Research Reveals that Physical and Cognitive Activities can Maintain and Improve Brain Functions of Patients with Mild Cognitive Impairments

Research
CUHK Launches Territory-wide Screening Study for Early Detection of Nasopharynx Cancer Now Recruiting 20,000 Citizens to Join

CUHK Launches Territory-wide Screening Study for Early Detection of Nasopharynx Cancer Now Recruiting 20,000 Citizens to Join

Research
CUHK Research Reveals Impact of Mild Hearing Loss on School Children Now Recruiting Hearing Impaired Students for Research on Efficacy of Intervention

CUHK Research Reveals Impact of Mild Hearing Loss on School Children Now Recruiting Hearing Impaired Students for Research on Efficacy of Intervention

Research
CUHK discovers that 40% of Individuals at Risk of Coronary Heart Disease have Pre-cancerous Bowel Tumors

CUHK discovers that 40% of Individuals at Risk of Coronary Heart Disease have Pre-cancerous Bowel Tumors

Research

Our Expert List

Many experts under the Faculty of Medicine are available for media interview.
Please click here for the expert list or contact us.